Oleoylethanolamide (OEA)

Dzina la malonda:Oleoylethanolamide, N-Oleoylethanolamide, OEA
Dzina lina:N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide , N-(2-Hydroxyethyl)oleamide
Nambala ya CAS:111-58-0
Molecular Formula:C₂₀H₃₉NO₂
Kulemera kwa Molecular:325.5
Kuyesa:90%, 95%, 85% min
Mawonekedwe:ufa wamtundu wa kirimu

Oleoylethanolamidendichinthu chatsopano pamsika wazakudya monga chowonjezera chazakudya chodziwika bwino chomwe chimagwiritsidwa ntchito pakuchepetsa thupi.Mafani ambiri omanga thupi akukambirana za oleoylethanolamide pa reddit ndi malo ena ochezera a pa Intaneti.

Oleoylethanolamide ndi metabolite yachilengedwe ya oleic acid yopangidwa m'matumbo aang'ono mkati mwa thupi la munthu.Zimachitika mwachilengedwe, ndipo akatswiri amazitcha "zosatha".

OEA ndiwowongolera mwachilengedwe wa njala, kulemera ndi cholesterol.Ndi metabolite yachilengedwe yomwe imapangidwa pang'ono m'matumbo anu aang'ono.OEA imathandizira kuwongolera njala, kulemera, mafuta amthupi ndi cholesterol pomanga cholandilira chodziwika kuti PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).M'malo mwake, OEA imachulukitsa kagayidwe ka mafuta am'thupi ndikuwuza ubongo wanu kuti mwakhuta ndipo ndi nthawi yoti musiye kudya.OEA imadziwikanso kuti imawonjezera ndalama zogwiritsira ntchito calorie zosakhudzana ndi masewera olimbitsa thupi.

Mbiri ya Oleylethanolamide

Ntchito zachilengedwe za Oleoylethanolamide zidapezeka zaka 50 zapitazo.Isanafike 2001, panalibe kafukufuku wambiri pa OEA.Komabe, chaka chimenecho, ofufuza a ku Spain adaphwanya lipid ndikuphunzira momwe amapangidwira, komwe amagwiritsidwa ntchito komanso zomwe amachita.Iwo anayesa zotsatira za OEA pa ubongo (wa makoswe) poyibaya mwachindunji mu ventricles ya ubongo.Sanapeze zotsatira pakudya ndikutsimikizira kuti OEA sichita mu ubongo, koma m'malo mwake, imayambitsa chizindikiro chosiyana chomwe chimakhudza njala ndi khalidwe la kudya.

Oleylethanolamide VS cannabinoid anandamide

Zotsatira za OEA zidaphunziridwa koyamba chifukwa zimagawana zofanana ndi mankhwala ena, cannabinoid omwe amadziwika kuti anandamide.Cannabinoids imakhudzana ndi chomera cha Chamba, ndipo ma anandamide omwe amapezeka muzomera (ndi chamba) amatha kukulitsa chikhumbo cha munthu chofuna kudya zakudya zopatsa thanzi poyambitsa kuyankha kwa chakudya.Malinga ndi Wikipedia, Oleoylethanolamide ndiye analogue ya monounsaturated ya endocannabinoid anandamide.Ngakhale OEA ili ndi mawonekedwe a mankhwala omwe ali ofanana ndi anandamide, zotsatira zake pa kudya ndi kulemera kwake ndizosiyana.Mosiyana ndi anandamide, OEA imachita mosadalira njira ya cannabinoid, kuwongolera zochitika za PPAR-α kuti zilimbikitse lipolysis.

Mapangidwe amitundu yosiyanasiyana yamafuta acid ethanolamide: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) ndi anandamide (arachidonoylethanolamide, AEA).(Cima Science Co., Ltd ndiye okhawo omwe amapanga zinthu zambiri zopangira OEA, PEA ndi AEA ku China, ngati mukufuna zitsanzo ndi mtengo wamtengo, chonde titumizireni imelo patsamba lathu.)

OEA imamanga ndi kuyanjana kwakukulu kwa peroxisome-proliferator-activated receptor-a (PPAR-a), cholandirira nyukiliya chomwe chimayang'anira mbali zingapo za lipid metabolism.

Magwero achilengedwe a oleoylethanolamide

Oleoylethanolamide ndi metabolite yachilengedwe ya oleic acid.Chifukwa chake, zakudya zomwe zili ndi oleic acid ndizomwe zimachokera ku OEA.

Oleic acid ndiye mafuta oyambira mumafuta amasamba monga azitona, canola ndi mpendadzuwa.Oleic acid imapezekanso mumafuta a mtedza, nyama, nkhuku, tchizi, ndi zina.

Zakudya zokhala ndi oleic acid ndizo: Mafuta a Canola, Mafuta a Azitona, Mafuta a Avocado, Mafuta a Almond, Mapeyala, Mafuta Ofunika Kwambiri Oleic.

Mfundo zina za Oleic Acid:

Chimodzi mwazinthu zodziwika kwambiri mu mkaka wa m'mawere wa munthu

Amapanga 25% ya mafuta mu mkaka wa ng'ombe

Monounsaturated

Omega-9 mafuta acid

Fomula ya mankhwala ndi C18H34O2(CAS 112-80-1)

Amakhala ndi triglycerides

Amagwiritsidwa ntchito mu zodzoladzola zamtengo wapatali monga moisturizer yothandiza kwambiri

Amapezeka mu mafuta amkaka, tchizi, mafuta a azitona, mafuta a mphesa, mtedza, ma avocados, mazira ndi nyama.

Mutha kukhala ndi udindo pazaumoyo wambiri wamafuta a azitona!

Amapanga ma super hero complexes ndi mapuloteni ena amkaka kuti amenyane ndi ma cell a khansa

Ubwino wa Oleoylethanolamide

Oleoylethanolamide (OEA) ndi yabwino kuonda ngati chowongolera chilakolako komanso imathandizira milingo ya cholesterol yabwino mwa akulu.

OEA ngati chopondereza chilakolako

Kuchepetsa chilakolako ndi gawo lalikulu lowongolera mphamvu (chakudya) kudya, kuwongolera chilakolako ndikofunikira pakuwongolera kulemera kwa thupi.Kodi OEA imalamulira bwanji chilakolako chanu?Mukhoza kuyang'ana ndondomeko ya zochita pansipa.

OEA ndi cholesterol

Mafuta a azitona ndiwopatsa thanzi, ndipo amathandizira kuchepetsa cholesterol "yoyipa" ya LDL ndikuwonjezera "zabwino" HDL.Chifukwa chiyani?Kufikira 85% yamafuta a azitona ndi oleic acid, ndipo metabolite yayikulu yathanzi ya oleic acid ndi OEA (Oleoylethanolamide ndiye dzina lathunthu).Chifukwa chake, palibe kukayika kuti OEA imathandizira cholesterol yabwino.

Kafukufuku wina akuwonetsa kuti oleoylethanolamide imakhala ndi zotsatira zabwino pa nkhawa, ndipo njira zambiri ndi umboni ndizofunikira kuti zithandizire.

Njira yopanga Oleoylethanolamide

Kuthamanga kwa Oleoylethanolamide kuli pansipa:

Masitepe onse ndi: reactiong→Kuyeretsa → Sefa → Kusungunulanso mu Mowa → hydrogenation → Sefa Madzi Oyera → crystallization → Sefa → Kuyesa → Kuyika → Mapeto

Njira yogwiritsira ntchito oleoylethanolamide

Kunena mwachidule, oleoylethanolamide amagwira ntchito ngati chowongolera njala.OEA imatha kuletsa kudya kwanu pouza ubongo kuti thupi lakhuta, ndipo palibenso chakudya chofunikira.Mumadya mochepa tsiku lililonse, ndipo thupi lanu likhoza kukhala losanenepa m’kupita kwa nthaŵi.

Zochita zotsutsana ndi kunenepa kwambiri za oleoylethanolamide (OEA) zikuwonetsedwa pachithunzichi.OEA imapangidwa ndikuphatikizidwa m'matumbo ang'onoang'ono oyandikana ndi oleic acid, monga mafuta a azitona.Zakudya zamafuta ambiri zimatha kulepheretsa kupanga OEA m'matumbo.OEA imachepetsa kudya mwa kuyambitsa homeostatic oxytocin ndi histamine brain circuitry komanso hedonic dopamine pathways.Pali umboni wosonyeza kuti OEA ingathenso kuchepetsa zizindikiro za hedonic cannabinoid receptor 1 (CB1R), kuyambitsa kwake komwe kumayenderana ndi kuchuluka kwa chakudya.OEA imachepetsa mayendedwe a lipid kukhala adipocytes kuti achepetse mafuta ambiri.Kufotokozeranso bwino za zotsatira za OEA pakudya ndi lipid metabolism kumathandizira kudziwa njira zakuthupi zomwe zitha kulunjika kuti apange njira zochiritsira za kunenepa kwambiri.

OEA imagwira ntchito kuyambitsa china chake chotchedwa PPAR ndikuwonjezera kuwotcha mafuta ndikuchepetsa kusungirako mafuta.Mukamadya, milingo ya OEA imachuluka ndipo chilakolako chanu chimachepa pamene mitsempha yolumikizana ndi ubongo imakuuzani kuti mwakhuta.PPAR-α ndi gulu la ligand-activated nuclear receptor lomwe limakhudzidwa ndi jini la lipid metabolism ndi njira za energyhomeostasis.

OEA ikuwonetsa mawonekedwe onse a satiety factor:

(1) Zimalepheretsa kudyetsa mwa kutalikitsa nthawi ya chakudya chotsatira;

(2) Kuphatikizika kwake kumayendetsedwa ndi kupezeka kwa michere ndi

(3) Miyezo yake imasinthasintha kusintha kwa circadian.

Zotsatira zoyipa za Oleoylethanolamide

Chitetezo cha Oleoylethanolamide ndichinthu chodetsa nkhawa kwambiri pakati paowonjezera omwe akufuna kuyesa chophatikizira chatsopanochi pamapangidwe awo ochepetsa thupi.

Pambuyo powunikiranso mwatsatanetsatane zolemba zonse zomwe zilipo, bungwe la US Food and Drug Administration (FDA) silinade nkhawa za chitetezo cha OEA.RiduZone ndiye chopangira choyamba cha oleoylethanolamide powder kuyambira 2015.

Oleoylethanolamide ndi metabolite ya oleic acid, yomwe ndi gawo lazakudya zatsiku ndi tsiku.Ndizotetezeka kuyesa zowonjezera za OEA, ndipo palibe zotsatira zoyipa zomwe zanenedwa.

zotsatira zanenedwa.

Oleoylethanolamide mayesero aumunthu

Mu kafukufuku wina, anthu makumi asanu (n = 50) omwe akufuna kuchepetsa thupi adalangizidwa kuti atenge OEA 2-3 nthawi / tsiku, mphindi 15-30 musanadye kwa masabata 4-12.Nkhani zikuphatikizapo anthu amene anali asanagwiritse ntchito kuwonda mankhwala kale, amene anakumana ndi mavuto ndi zinthu zina kuwonda, amene kuwonda plateaued pa wothandizila kuwonda monga phentermine, amene akuyesera kukhazikitsa moyo kalembedwe kusintha (gawo ulamuliro ndi kuchita masewera olimbitsa thupi nthawi zonse. ), ndi omwe amayang'aniridwa mwachangu pazachipatala kuphatikiza kulolerana kwa glucose, dyslipidemia, matenda oopsa komanso matenda amtima.

Mu phunziro lachiwiri, maphunziro a 4 okhala ndi zolemera zoyambira za 229, 242, 375 ndi 193 lbs motsatira, adalangizidwa kuti atenge makapisozi a Oleoylethanolamide (capsule imodzi yomwe ili ndi 200mg 90% OEA).Ophunzira adatenga makapisozi a 4 (kapisozi 1 mphindi 15-30 musanadye ndipo adayenera kutenga kapisozi wowonjezera asanadye chakudya chachikulu chatsiku) tsiku lililonse kwa masiku 28.Nkhani yomaliza idayikidwapo kale lap band.Ophunzirawo adalangizidwa kuti asasinthe zakudya zawo komanso machitidwe ochita masewera olimbitsa thupi.

Zotsatira

Pakufufuza koyamba, anthu adataya pafupifupi 1-2 lbs / sabata.Panalibe zotsatirapo zake kupatulapo wodwala mmodzi yemwe anali ndi nseru yosakhalitsa yomwe inathetsedwa pasanathe sabata.Mu phunziro lachiwiri, 3 mwa maphunziro a 4 adanena kuti ataya thupi (3, 7, 15 ndi 0 lbs motsatira).Mitu yonse ya 4 inanena kuti kuchepa kwa 10-15% mu kukula kwa gawo, nthawi yayitali yapakati pa chakudya, ndipo palibe zotsatirapo.

Ngati mukufuna kudziwa zambiri zamayesero a anthu ndi OEA, chonde pitani ulalo wa PDF womwe mungatsitse.

Oleoylethanolamide mlingo

Pali chidziwitso chochepa cha kafukufuku wokhudzana ndi zowonjezera za OEA mwa anthu, ndipo ngakhale zimawonedwa ngati zotetezeka, palibe mlingo wovomerezeka.Komabe, pali zina zowonjezera pamsika, ndipo mutha kupeza zina kuti mufotokozere.

Mlingo wa tsiku la RiduZone (wotchedwa OEA/Oleoylethanolamide 90%) ndi 200mg (1capsule yokhala ndi OEA yokhayo).Ngati ataphatikizidwa pamodzi ndi zosakaniza zina zochepetsera thupi, mlingo wa tsiku ndi tsiku umawoneka wochepa, kunena kuti 100mg kapena 150mg.Zina zowonjezera

Ndikofunikira kuti mutenge oleoylethanolamide zowonjezera mphindi 30 musanadye chakudya cham'mawa ndi chakudya chamadzulo, mudzamva kukhuta panthawi yazakudya ndipo chifukwa chake mutha kudya pang'ono.

Zolemba zofufuza za oleoylethanolamide

Oleoylethanolamide: wosewera watsopano mu mphamvu ya metabolism.Udindo mu kudya

Oleoylethanolamide imawonjezera kufotokozera kwa PPAR-Α ndikuchepetsa chilakolako ndi kulemera kwa thupi mwa anthu onenepa: mayesero azachipatala.

Mamolekyulu a Ubongo ndi Kulakalaka: Nkhani ya Oleoylethanolamide

Oleylethanolamide imayang'anira kudyetsa ndi kulemera kwa thupi kudzera mu kuyambitsa kwa nyukiliya receptor PPAR-a

Kutsegula kwa TRPV1 ndi Satiety Factor Oleoylethanolamide

Kuwongolera kudya kwa oleoylethanolamide

Njira ya oleoylethanolamide pamafuta acid amatengedwa m'matumbo ang'onoang'ono mutatha kudya komanso kuchepetsa thupi.

Oleoylethanolamide: Udindo wa bioactive lipid amidein modulating kudya

Oleoylethanolamide: Wothandizira mafuta polimbana ndi kunenepa kwambiri

Oleoylethanolamide: Novel Potential Pharmacological Alternative to Cannabinoid Antagonists pakuwongolera Kulakalaka.