Product Name:Agomelatine

Rimwe Zita:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

Nhamba yeCAS:138112-76-2

Zvinodiwa: 99.0%

Ruvara: Ichena poda yakatsetseka ine hunhu hwemunhuwi uye kuravira

GMO Mamiriro:GMO Yemahara

Kurongedza: mune 25kgs fiber zvigubhu

Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba

Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa

Agomelatinerudzi rutsva rwemishonga inoderedza kuora mwoyo. Maitiro ayo ekuita anotsemuka kuburikidza neyakajairwa monoamine transmitter system.Agomelatine is melatoninergic agonist uye antagonist anosarudza we5-HT2C receptors, uye yakaratidzwa kuve inoshanda mumhando dzakawanda dzemhuka dzekuora mwoyo. Agomelatine (S20098) yakaratidza pKi tsika dze6.4 uye 6.2 pakuzvarwa (porcine) uye yakagadzirwa, munhu (h) 5-hydroxytryptamine (5-HT) 2C receptors, zvichiteerana.

Agomelatine imwe mhando yehupfu-chena kana chena yekristaro kana chena yakasimba. IUPAC Zita rekemikari iyi N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. Kemikari iyi ndeye Aromatics Compounds;Aromatics;Neurochemicals;APIS. Inofanira kuchengetwa pa -20°C Freezer.

 
Sezvo Pharmaceutical Intermediates, Agomelatine inoshandiswa mukurapa kukuru kwekuora mwoyo, kusagadzikana kwepfungwa. Agomelatine inoshandiswa mukurapa kwekuora mwoyo kukuru, kusagadzikana kwepfungwa. Mushonga weNervous system. Antidepressant, anxiolytic, kugadzirisa rhythm yekurara uye kudzora biological wachi. Agomelatine ndeye melatoninergic agonist uye anosarudza anopikisa we5-ht2c receptors. Agomelatine mushonga unoderedza kuora mwoyo. Inorondedzerwa se norepinephrine-dopamine disinhibitor (NDDI) nekuda kwekupikisa kwayo kwe5-HT2C receptor. Agomelatine zvakare ine simba agonist pa melatonin receptors iyo inoita kuti ive yekutanga melatonergic antidepressant.

.Agomelatine yakanyatsoenderana nemelatonin. Agomelatine inyanzvi ine simba pa melatonin receptors uye anopikisa pa serotonin-2C (5-HT2C) receptors, yakaedzwa mumuenzaniso wemhuka wekuora mwoyo.

Agomelatine inonzi antidepressant inoshandiswa kurapa kuora mwoyo.

Uropi hunowanzoita zvakanaka pakuva nechokwadi chekuti tine zvakakwana zvemakemikari atinoda kuti ashande zvakanaka. Asi kuora mwoyo kunogona kukanganisa makemikari akawanda europi.

Aya makemikari anosanganisira noradrenaline, dopamine uye serotonin; kuora mwoyo kunoderedza mazinga eaya ma<em>brain transmitters. Kuora mwoyo kunokanganisawo kemikari inonzi melatonin. Yakaderedzwa melatonin inobatanidzwa nekuvhiringidza mumaitiro edu ekurara.

Agomelatine ndiyo yekutanga antidepressant kuwedzera melatonin basa zvakananga. Inoita izvi nekuita senge melatonin panzvimbo dzakanangwa dzinoshanda melatonin. (Izvi zvinozivikanwa se melatonin receptors). Nekuwedzera basa re melatonin, agomelatine inowedzerawo zvakananga chiitiko che noradrenaline uye dopamine.

Agomelatine yakatanga kuvhurwa muEurope muna 2009 uye yave kubvumidzwa kushandiswa munyika dzinopfuura makumi manomwe. Kusiyana nechinyakare antidepressants, agomelatine inoshanda nekunanga melatonin uye serotonin receptors muuropi. Nekuita seanopikisa pa melatonin receptors, agomelatine inobatsira kudzoreredza maitiro ekurara akakanganisika anowanzo sangana nekuora mwoyo. Iyi michina haingobatsiri kuvandudza kunaka kwekurara asiwo inobatsira kudzoreredza echisikigo circadian rhythms. Mukuwedzera, agomelatine inoita seanopikisa pane mamwe serotonin receptors (5-HT2C receptors). Ichi chakasarudzika chiito cheviri chinosimudzira kuwanikwa kweserotonin muuropi, neurotransmitter ine basa rekudzora manzwiro. Nokugadzirisa mazinga e serotonin, agomelatine inogona kuita seyakagadzirisa kuora mwoyo, kubvisa zviratidzo zvakadai sekusuruvara, kurasikirwa kwechido, kunzwa uine mhosva kana kusakosha. Uyezve, agomelatine inogona kupa mamwe mabhenefiti. Tsvagiridzo inoratidza kuti inogona kubatsira kuvandudza basa rekuziva Tsvagiridzo inoratidza kugona kwayo kusimudzira ndangariro, kutarisisa, uye basa rekutonga, zvichiita kuti ive nzvimbo inonakidza yekutsvaga ramangwana.

Basa:

Agomelatine inogona kubatsira kudzora wachi yako yemuviri (circadian rhythm) ine mabhenefiti akanaka pakuora mwoyo nehope Agomelatine inoshandiswa mukurapa kuora mwoyo kana kubatsira kudzivirira kuora mwoyo kudzoka, uye inongowanikwa chete netsamba yachiremba. Zviratidzo zvekuora mwoyo zvinosiyana kubva kumunhu mumwe zvichienda kune mumwe, asi zvinowanzobatanidza kusuruvara kunoramba kuripo, kurasikirwa nechido mumabasa aunofarira, kunzwa usingabatsiri, zvinetso zvekurara, kunzwa kunonokerwa, manzwiro ekuzvidya mwoyo kana kuchinja kwechido uye uremu. Shanduko mukurara kwako kwezuva nezuva uye mafambiro ekudya mienzaniso yekuvhiringika kwewachi yemuviri wako kunoitika kazhinji kusagadzikana.