Lebitso la Sehlahisoa:Motsoako oa 7P

Lebitso le Leng:Compound7P;2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide ;2-(N-(2-methoxyphenyl)-4- methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide

Nomoro ea CAS:1890208-58-8

Litlhaloso: 99.0%

'Mala: phofo e tšoeu e nang le monko le tatso e ikhethang

Boemo ba GMO:GMO Mahala

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

Compound 7p e bontšitsoe ho susumetsa kholo ea li-axon tsa GAP-43-positive ka mohlala oa phoofolo ea kotsi ea methapo ea optic, e fana ka maikutlo a hore ts'ebetso ea neurite outgrowth ea motsoako oa 7p in vitro e fetolela ho tsosoa ha axon ho tsosolosoa ha Vivo.

Mohlala oa phoofolo ea kotsi ea methapo ea kutlo, motsoako oa 7p o ile oa bontšoa ho etsa hore ho be le li-axon tse ntle tsa gap-43, tse bontšang hore in vitro neurite outgrowth mosebetsi oa motsoako oa 7p o fetolela ho tsosoa ha axon regeneration ka vivo. ea mekhoa eo ka eona e etsang hore axon e nchafatsoe ka har'a vivo e tla fana ka motheo o utloahalang bakeng sa boiteko ba nakong e tlang ba ho ntlafatsa. mekhoa ea phekolo.

Compound 7P e bolela motsoako o itseng oa tlhaho o nang le liathomo tse supileng tsa carbon. Ka k'hemistri ea lintho tse phelang, carbon ke ntho ea bohlokoa hobane e ka theha maqhama a tsitsitseng le liathomo tse ling, ho akarelletsa le liathomo tsa carbon, ho etsa limolek'hule tse rarahaneng. Limolek'hule tsena li ka ba le thepa le mesebetsi e sa tšoaneng, 'me li etsa hore metsoako e entsoeng ka k'habone e be lintho tse ahang bophelo. Mefuteng ea liphoofolo tsa kotsi ea methapo ea optic, motsoako oa 7p o ile oa bontšoa ho etsa hore ho be le li-axon tse ntle tsa GAP-43, tse fanang ka maikutlo a hore mosebetsi oa ho hōla ha neurite oa motsoako oa 7p in vitro o fetolela ho tsosoa ha axonal ho tsosolosoa ha vivo. Motsoako oa 7P phofo ke phofo e tšoeu ho ea ho e tšoeu e hlahisoang e le motsoako oa tandem bakeng sa ho tsebahatsa li-inhibitors tse peli tse sebetsang ka thromboxane receptor antagonist. Ha e le hantle, motsoako oa 7p o bontšitse selectivity bakeng sa prostaglandin I2 synthase (PTGIS, CYP8A1) e amanang le thromboxane synthase (CYP5A1). Motsoako oa nootropic 7P phofo o khothalletsa ho hōla ha li-axon tsa Gap-43-positive, kahoo li susumetsa ho tsosolosoa ha axonal 'meleng. Complex 7p ea boleng bo holimo e etselitsoe ho ntlafatsa khokahanyo, ho ntlafatsa maikutlo le ho thusa ho loantša mokhathala. E boetse e thibela oxidation bokong le ho thusa ho loantša tšenyo ea boko e bakoang ke ho noa joala.

Mosebetsi:

Ho tsosolosoa ha li-axon ka mor'a kotsi tsamaisong ea methapo e bohareng e sitisoa ka karolo e itseng hobane haeba ho fokotseha ho itšetlehileng ka lilemo ho matla a ho hōla a axon, 'me e' ngoe ea mekhoa ea ho susumetsa kholo ea axon ho li-neurone tse lemetseng e kenyelletsa ho qhekella ha pharmacological ea litsela tse amehang tsa pontšo.mona re tlaleha. phenotypic cell-based screen ea lilaebrari tsa lik'hemik'hale le ts'ebetso e tataisoang ke ts'ebetso e entseng hore ho khethoe komporo ea 7p eo. e khothalletsa ho hola ha methapo ea kutlo ea methapo ea kutlo ea mantlha e tsoang ho hippocampus, cerebral cortex le retina. ka mohlala oa phoofolo ea kotsi ea methapo ea kutlo, motsoako oa 7p o bontšitsoe ho etsa hore ho be le li-axon tse ntle tsa lekhalo-43, tse bontšang hore in vitro neurite outgrowth mosebetsi oa motsoako 7p e fetolela ho tsosoa ha axon regeneration ka vivo. ea mekhoa eo ka eona e etsang hore axon e nchafatsoe ka har'a vivo e tla fana ka motheo o utloahalang bakeng sa boiteko ba nakong e tlang ba ho ntlafatsa. mekhoa ea phekolo.
Kopo:

Hona joale ke lithethefatsi tse bohlale tsa nootropic tse itlhahisang ho e 'ngoe ea li-racetam tse matla ka ho fetisisa bokahohleng ba nootropic. E entsoe ka sehlopha sa metsoako e bitsoang li-racetams, 'me ha e sebetse feela ka acetylcholine empa hape le li-receptor tsa GABA bokong, sena se na le bokhoni ba ho kenya li-receptor tsa cholinergic le glutamate tsa cerebral cortex,' me ke lithethefatsi tsa racetam tse fetolang ka lebaka la eona haholo. mokhoa o ikhethang oa ketso. Hona joale Fasoracetam e boetse e bontša melemo e le anti-depressant, ADHD stimulant, le anxiolytic, hape, joalokaha ho pakoa li laboratori ho pholletsa le naha, e thusa ka ho theha le ho boloka mehopolo e mecha.