Lebitso la Sehlahisoa:Galantamine Hydrobromide
Lebitso le Leng:Galanthamine hydrobromide;Galantamine HBr; Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,Hydrobromide
CAS NO:1953-04-4
Litlhaloso:98.0%
Mmala:Bosoeuphofo e nang le monko le tatso e ikhethang
Boemo ba GMO:GMO Mahala
Ho paka: ka meqomo ea fiber ea 25kgs
Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla
Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso
Galantamine e sebelisoa bakeng sa ho phekola lefu la Alzheimer le bonolo ho isa boemong bo itekanetseng le mathata a mang a fapaneng a ho hopola, haholo-holo a nang le tšimoloho ea methapo. Ke alkaloid e fumanoang ka maiketsetso kapa ho bulbs le lipalesa tsa Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) le genera e amanang le eona joaloka Narcissus (daffodil)), Leucojum(snowatake) le Lycoris radiscoris Red Spider Lily).
Galanthamine ke tlhaho e ntšitsoeng ho lycoris radiate, ke alkaloid e phahameng e nkiloeng ho lerotholi la lehloa le mefuta e amanang haufi-ufi. E sebetsa e le acetylcholinesterase inhibitor (ACHE) inhibitor ea tlhōlisano, ha e ntse e sebetsa e fokola ho butyrylcholinesterse(BuChE) .e sebelisoa ho phekola mathata a tsamaiso ea methapo e bohareng 'me e ka sebelisoa e le antidote ea ho phomola mesifa e sa tsitsang.Galanthamine hydrobromide bosoeu ho hoo e ka bang phofo e tšoeu; qhibilihang ka mokhoa o fokolang ka metsing; chloroform e sa qhibilihang, ether le joala .
Galantamine hydrobromide ke benzazepine e nkiloeng ho bulbs le lipalesa tsa narcissus, osmanthus kapa canna. Hape ke molomo oa cholinesterase inhibitor. Joaloka ligand bakeng sa li-receptor tsa nicotinic acetylcholine, e 'nile ea sebelisoa haholo ho ntlafatsa ts'ebetso ea methapo ea kutlo. Mosebetsi oa eona ke ho thibela acetylcholinesterase ka tlholisano le ka mokhoa o feto-fetohang, ka hona ho eketsa bongata ba acetylcholine. Ha e kenngoa maling, galantamine hydrobromide e kenella habonolo likarolong tse sa tšoaneng tsa 'mele, ho akarelletsa le boko. E tlama ho li-receptor tsa nicotinic acetylcholine, e bakang liphetoho tsa conformational le ho eketsa tokollo ea acetylcholine. E boetse e sebetsa ka ho qothisana lehlokoa le ho khutlisa litlamorao tsa li-inhibitors tsa cholinesterase. Ka ho thibela cholinesterase, e thibela ho senyeha ha acetylcholine, kahoo e eketsa maemo le nako ea neurotransmitter ena e matla. Galantamine e ka boela ea ntlafatsa ho ithuta le ho hopola, ho thibela ho ruruha ha boko, le ho boloka maemo a phahameng a li-neurotransmitters ka ho boloka botšepehi ba li-neurone le li-synapses.
Mosebetsi:
(1) Anti-cholinesterase .
(2) Ho susumetsa le ho thibela acetylcholinesterase, ho laola boemo ba intracephalic nicotine receptor.
(3) O phekola lefu la ho holofala ha masea sequelae, sweeny le myasthenia gravis pseudoparalytica, joalo-joalo.
(4) Ntlafatsa ts'ebetso ea tlhokomeliso ea leseli, bakuli ba lefu la Alzheimer ba bobebe haholo, le ho liehisa ts'ebetso ea phokotso ea lisele tsa boko.
(5) Ntlafatsa tsamaiso pakeng tsa methapo le mesifa.
Kopo
1. GalanthamineHydrobromidee sebelisoa haholo-holo ho myasthenia gravis, poliovirus quiescent stage le sequela, hape le polyneuritis, funiculitis le sensorimotor barrier e bakoang ke lefu la tsamaiso ea methapo kapa traumatism;
2. Galanthamine Hydrobromide e boetse e sebelisoa ho lefu la Alzheimer, e na le mosebetsi o ka sehloohong bakeng sa dementia le dysmnesia e bakoang ke tšenyo ea boko ba tlhaho.
