L-ERGOTHIONEINE 99% KA HPLC
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1. Tlhaloso ea Sehlahisoa
L-Ergothioneine(ERT) ke sebabole se nang le amino acid e tsoang ho belisoa ha likokoana-hloko, haholo-holo tse fumanoang li-mushroom tse kangTricholoma matsutakeleHericium erinaceus. Sehlahisoa sa rona ke bohloeki bo phahameng (≥99% ka HPLC) phofo ea crystalline e nang le CAS No. 497-30-3, e tiisitsoeng ka tlhahlobo e matla ea chromatographic. E bonts'a botsitso bo ikhethang mefuteng ea pH 4.0-6.0, e etsa hore e be e loketseng li-serum tsa skincare, lotions, le li-supplement tsa molomo.
Likarolo tsa Bohlokoa:
- Bohloeki: ≥99% (COA e tiisitsoeng ka HPLC, COA e khethehileng e fanoe)
- Foromo ea Molek'hule: C₉H₁₅N₃O₂S | Boima ba 'mele: 229.3 g/mol
- Solubility: 125 mg/mL ka metsing (ho thusoa ke ultrasonic)
- Setifikeiti: Non-GMO, Allergen-Free, Vegan-Friendly
2. Taolo ea Boleng & Mokhoa oa HPLC
Ts'ebetso ea rona ea tlhahlobo e tsamaisana le liprothokholo tse hlahlobiloeng ke lithaka:
- Boitokisetso ba Mohlala: 1 mL setso sa setso se phehiloeng ka 94 ° C bakeng sa 10 min, vortexed (1600 rpm / 30 min), centrifuged (10,000×g / 5 min), 'me e bolokiloe ho -20 ° C ha ho hlokahala.
- Sistimi ea HPLC: Dionex Ultimate 3000 e nang le software ea Chromeleon.
- Kholomo: Cortecs UPLC T3 (2.1 × 150 mm, 1.6 μm likaroloana, 120 Å pore boholo) .
- Mobile Phase: Gradient elution ho tloha 0.1% formic acid ho 70% acetonitrile / 0.1% formic acid, sekhahla sa phallo 0.3 mL / min.
- Ho lemoha: Monyetla oa UV ho 254 nm, LOQ 0.15 mmol/L.
Melemo ea netefatso:
- Boemo: 0.3–10 mmol/L (R² >0.99)
- Ho nepahala: ≤6% RSD (intra-/inter-assay)
- Ho hlaphoheloa: ~ 100% ho nepahala
3. Melemo ea Bophelo le Likopo
3.1 Tšebeliso ea Nutraceutical
- Tšireletso ea Mitochondrial: E fokotsa khatello ea kelello ea oxidative ka ho senya hydroxyl radicals (IC₅₀: 2.5 μM) le superoxide anions.
- Tšehetso ea Telomere: E lieha ho khutsufatsa telomere e amanang le lilemo ka har'a vitro.
- Tekanyetso: Liphuputso tsa bongaka li fana ka maikutlo a hore 5-20 mg / letsatsi e phahamisa maemo a ERT a plasma haholo.
Lihlahisoa tse khothalelitsoeng:
- Li-capsules: 100 μg–5 mg ka ho sebelisoa (mohlala, LifeExtension's Essential Youth) .
- Synergistic Blends: E kopanya le ferulic acid bakeng sa ho ntlafatsa bioavailability.
3.2 Tšebeliso ea Litlolo
- Anti-Botsofali: E thibela tyrosinase (phokotso ea 40% ho 0.5% concentration) mme e sireletsa elastin ho senyeha ha UV.
- Tataiso ea Tlhahiso:
- pH: 4.0–6.0 (botsitso bo nepahetseng)
- Ho tsepamisa mohopolo: 0.5-2.0% ka li-serum / lotions
- Ho lumellana: E tsitsitse ka vithamine C, hyaluronic acid, le peptides.
4. Lintlha tsa Setegeniki
| Paramethara | Tlhaloso | Referense |
|---|---|---|
| Ponahalo | Phofo e tšoeu ea kristale | |
| Purity (HPLC) | ≥99% | |
| Melting Point | 275–280°C (e senyeha) | |
| Polokelo | 2–8°C ka setshelong se sa keneng moya | |
| Shelf Life | Likhoeli tse 24 |
5. Tšireletseho & Tumellano ea Taolo
- Lintlha tsa Polokeho: LD₅₀>2000 mg/kg (molomo, likhoto); ha ho na liphello tse bohloko litekong tsa batho .
- Ditifikeiti: Tumello ya dijo tsa EU Novel (Ergoneine®), FDA GRAS .
- Ho tšoara: Sebelisa li-respirators tse lumelitsoeng ke NIOSH le li-gloves tse thibelang lik'hemik'hale nakong ea ts'ebetso ea indasteri .
6. Global Supply & Packaging
- Likhetho tsa ho paka: 1 kg, 10 kg, 1000 kg (mekotla ea aluminium foil e nang le desiccant) .
- Nako ea Pele: Matsatsi a khoebo a 3-5 (ho romelloa lefatšeng ka bophara ka DHL/FedEx) .
- Limmaraka li Sebetsa: USA, EU, Australia, Japan, Brazil.
7. Mantsoe a Sehlooho
- Mantsoe a sehlooho: “L-Ergothioneine 99%HPLC", "Natural Antioxidant Supplier", "Ergothioneine for Skincare".
- Kenyelletsa CAS 497-30-3, likopo tsa bohloeki, le lipehelo tsa kopo.
