Igama lemveliso: 4-Butylresorcinol powder
Inkcazo: 98% min
Inombolo yeCAS: 18979-61-8
Izithethantonye zesiNgesi: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,I-4-DIHYDROXY-N-BUTYLBENZEN
Ifomula yemolekyuli: C10H14O2
Ubunzima bemolekyuli: 166.22
Indawo yokunyibilika: 50 ~ 55℃
Indawo yokubila: 166℃/7mmHg(lit.)
Umthamo: 0.1-5%
Iphakheji: 1kg, 25kg
Yintoni i-4-Butylresorcinol
Igama lekhemikhali elisemthethweni yi-4-n-butyl resorcinol, kodwa ngokuqhelekileyo, wonke umntu uthanda ukwenza lula ukubhala i-butyl resorcinol.Owokuqala ukuyongeza kwimveliso emhlophe yiPOLA yaseJapan, um~ lowo uxhomekeke kwipilisi yomhlophe kumlilo wasekhaya.
Ibonakala ngokunganyibiliki kakuhle emanzini kwaye inyibilika kwi-ethanol.
Isenzo se-Mechanism ye-4-Butylresorcinol
- I-Tyrosinase idlala indima ebalulekileyo kwimveliso ye-melanin kuba ilawula umlinganiselo we-melanin deposition.
- I-4-n-butylresorcinol inempembelelo yokuthintela kwimveliso ye-melanin ngokuthintela ngokuthe ngqo umsebenzi we-tyrosinase kunye neeseli ze-tumor ze-B16 ezimnyama ezivimbela ukuhlanganiswa kwe-tyrosinase ngaphandle kokubangela nayiphi na i-cytotoxicity.
- Kwezinye izifundo ze-in vitro, i-4-n-butylresorcinol iboniswe ukuvimbela ukuveliswa kwe-melanin, kunye nomsebenzi we-tyrosinase kunye ne-TRP-1.
- Inhibitor enamandla ye-tyrosinase kunye ne-peroxidase
- I-agent esebenzayo yokwenza mhlophe yesikhumba kunye ne-skin toner eqhelekileyo
- I-agent esebenzayo yokwenza mhlophe kwi-pigmentation yesikhumba
- Isebenza ngokuchasene ne-chloasma (isikhumba esinepigmented esicacileyo elangeni)
- Inefuthe elinamandla lokukhusela kumonakalo we-DNA owenziwe yi-H2O2.
- Ibonakaliswe ukuba ine-anti-glycation effect
Izibonelelo ze-4-Butylresorcinol
Kutheni kufuneka ukhethe i-4-Butylresorcinol
Okokuqala, kufuneka sazi ukuba kutheni kukho i-resorcinol.
ILipofuscin yenye yezona zinto zinzima kakhulu ukujongana ne-melanin.Ngokubanzi, i-hydroquinone isetyenziswa kubuhle bezonyango.
IHydroquinone yeyona nto isebenzayo yokwenza mhlophe.Indlela emhlophe ivimbela ngokupheleleyo umsebenzi we-tyrosinase kwaye ivimbela ukubunjwa kwe-melanin, kwaye umphumo uphawuleka kakhulu.
Nangona kunjalo, iziphumo zayo zecala zibonakala ngokulinganayo, kwaye iinzuzo ziyingozi kakhulu kuneenzuzo zokumhlophe.
- I-oxidizable kakhulu emoyeni, kwaye kufuneka isetyenziswe xa iyongezwa kwizinto zokuthambisa.
- kunokubangela ubomvu kwesikhumba;
- Ukuba i-concentration idlula i-5%, iya kubangela i-sensitization, kwaye kukho imizekelo yekliniki ye-leukoplakia.Okwangoku, i-US Food and Drug Administration ichaza ukuba iimveliso ze-hydroquinone ezinoxinaniso olukhulu kune-4% ziyibakala lezonyango kwaye azivumelekanga ukuba zithengiswe.
Oosokhemesti kunye noosokhemesti balungise ichiza elinamandla i-hydroquinone ukuze bafumane i-4-hydroxyphenyl-beta-D-glucopyranoside, nto leyo esihlala siyiva nge-"arbutin".Umahluko phakathi kwe-hydroquinone kukuba i-arbutin inomsila omncinci-i-glycoside kune-hydroquinone.Kulusizi ukuba umphumo wobumhlophe uyancipha kakhulu.
Kwiminyaka yakutshanje, ezona zithako zidumileyo zeempawu eziphambili zizinto ezahlukeneyo zebenzenediol.
Kodwa ukuzinza okukhanyayo kwe-arbutin kubi kakhulu kwaye kusebenza kuphela ebusuku.
Ukhuseleko lwe-4-n-butyl resorcinol luye lwaba luphawu olubalaseleyo.Ngaphandle kweziphumo ebezingalindelekanga ze-hydroquinone, inesiphumo esingcono sonyango kunezinye izinto eziphuma kwi-resorcinol.
Kuvavanyo lokuthintela umsebenzi we-tyrosinase, idatha yayo ibhetele ngakumbi kune-big brother phenethyl resorcinol, eyi-100 ~ 6000 amaxesha e-agent emhlophe yendabuko efana ne-kojic acid arbutin!
Emva koko kuvavanyo oluphambili olulandelayo lwe-melanin B16V, luphinde lwabonisa inzuzo eqhelekileyo ye-resorcinol derivatives - inhibition yemveliso ye-melanin kwiindawo ezingazange zivelise i-cytotoxicity.
Ukongeza, zininzi iimvavanyo zabantu kwi-4-n-butyl resorcinol.Kwezinye izigulane ze-32 ezine-chloasma, i-0.3% ye-4-n-butylresorcinol kunye ne-placebo zisetyenziswe kuzo zombini izihlathi.Kabini ngosuku kwiinyanga ze-3, umphumo waba yinto ephantsi kakhulu yokunciphisa i-pigment kwiqela le-4-n-butylresorcinol kuneqela le-placebo.Kukho abantu abenza umfuniselo we-pigmentation inhibition eyenziweyo emva kokutshiswa lilanga okwenziwa ngokwenziwa, hmm~ isiphumo ngokuqinisekileyo silungile ~
Ukuvinjelwa kwe-tyrosinase yomntu nge-4-butylresorcinol
I-4-butylresorcinol, i-kojic acid, i-arbutin kunye ne-hydroquinone ibonisa kwi-L-DOPA oxidase umsebenzi we-tyrosinase.Igqitywe ngamaqondo ahlukeneyo e-inhibitors ukuvumela ukubalwa kwamaxabiso e-IC50.Le datha ngumyinge wemifuniselo emithathu ezimeleyo.
Ukuthintela ukuveliswa kwemelanin kwiimodeli zesikhumba zeMelanoDerm nge4-butylresorcinol
Thelekisa kunye ne-4-butylresorcinol, i-kojic acid, i-arbutin kunye ne-hydroquinone kwimveliso ye-melanin.Ukuzimisela komxholo we-melanin kwiimodeli zesikhumba kuboniswe emva kweentsuku ezili-13 zokulima phambi koxinzelelo lwe-inhibitor eyahlukeneyo.Le datha ngumyinge wemifuniselo emihlanu ezimeleyo.
Ubudala bukhanyisa nge-4-butylresorcinol
Thelekisa nge-4-butylresorcinol, i-kojic acid, i-arbutin kunye ne-hydroquinone.Nyanga amabala kabini ngemini kwiiveki ezili-12 nge-inhibitor efanelekileyo.Vavanya impumelelo emva kwe-4, 8 kunye ne-12 yeeveki.Idatha imele intsingiselo yezifundo ze-14.*P <0.05: ibalulekile ngokwezibalo vs. amabala obudala angaphathwanga.
Umthamo kunye nokusetyenziswa kwe-4-Butylresorcinol
Umthamo ocetyiswayo ngu-0.5% -5%.Nangona kukho izifundo e Korea ukuba nefuthe elithile cream 0.1%, kwaye India uphando 0.3% cream kodwa imarike ikakhulu 0.5% -5%.Ixhaphake kakhulu, kwaye ifomula yaseJapan ayikacaci, kodwa iPOLA isetyenzisiwe.Kwaye iziphumo kunye neentengiso ziyamangalisa.
Njengoko kukhankanyiwe ngasentla, i-4-Butylresorcinol ingasetyenziselwa kwiikhilimu, kodwa ayinyibiliki emanzini.Ezinye ezifana nezinto zokuthambisa, iikhrimu, neejeli nazo ziyafumaneka.Zombini i-POLA kunye ne-Eucerin zineemveliso ze-4-Butylresorcinol.
