Igama lemveliso:I-CMS121

Elinye Igama:CMS-121;

1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,I-2-diol(CMS121);

I-ACC, i-AcetylCoenzymeACarboxylase, isifo, i-neuroprotective, inhibit, anti-inflammatory, mitochondrial, i-Alzheimer's, i-antioxidative, i-acetylation, i-Inhibitor, i-H3K9, i-Acetyl-CoACarboxylase, i-CMS121, i-dementia, i-ACC1, i-CMS-121

INOMBOLO YECAS.1353224-53-9

IsiVavanyo: 98.0%Mis

Umbala: Umgubo otyheli okhanyayo

Ukupakisha: 25kg / DRUMS

I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yikhompawundi ekwabizwa ngokuba yiCMS121. Ukuntsonkotha kolwakhiwo lwekhompawundi kubonisa ukuba inokuba neepropati ezizodwa kunye nokusetyenziswa okunokwenzeka. Ukuqonda ukubaluleka kwayo, kunceda ukuchonga amaqela asebenzayo akhoyo kwaye ahlalutye impembelelo yawo enokubakho

I-CMS121 yindawo yequin oline ene-neuroprotective, anti-inflammatory, antioxidative, kunye ne-renoprotective activities. Igcina amanqanaba e-glutathione (GSH) kwiiseli ze-HT22 ze-hippocampal kwi-vitro phambi kwe-glutamate, ibangela ukuhlukana kweeseli ze-PC12, ikhusela i-LPS-induced N9 microglial activation nge-82% kwi-N9 microglia, kunye ne-scavenges i-radicals yamahhala kwi-concentration ye-Trolox elinganayo. (TEAC) uvavanyo. I-CMS121 ikhusela i-ischemia kunye ne-oxytosis kwizikrini ze-phenotypic kwiiseli ze-HT22 kwi-vitro enexabiso le-EC50 le-7 kunye ne-200 nM yokukhusela i-iodoacetic acid- okanye i-glutamate-induced cell death, ngokulandelanayo. Kwakhona i-renoprotective, iyancipha ukulahleka kwesisindo sezintso kunye nokunciphisa ukubonakaliswa kwe-TNF-α, i-caspase-1, kunye ne-inducible nit ric oxi de synthase (iNOS) kwimodeli ye-mouse ye-SAMP8 yesifo sezintso ezingapheliyo ezinxulumene nokuguga ngokukhawuleza xa kulawulwa kwidosi. ye-10 mg/kg ngosuku ukuqala kwiinyanga ezilithoba ubudala.

I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yikhompawundi ekwabizwa ngokuba yiCMS121. Ukuntsonkotha kolwakhiwo lwekhompawundi kubonisa ukuba inokuba neepropati ezizodwa kunye nokusetyenziswa okunokwenzeka. Ukuqonda ukubaluleka kwayo, kunceda ukuchonga amaqela asebenzayo akhoyo kwaye ahlalutye impembelelo yawo enokubakho. Ubukho beringi yequinoline bucebisa ukuba ikhompawundi inokusebenza ngokwebhayoloji. Iimolekyuli eziphuma kwi-Quinoline ziyaziwa ngeempawu zazo ezahlukeneyo zebhayoloji, kubandakanya imisebenzi yokulwa ne-antibacterial kunye ne-anti-inflammatory. I-Attachment yeqela le-cyclopentyloxy inokufaka isandla kwi-solubility ye-compound okanye ukuphucula umsebenzi wayo webhayoloji ngemiphumo ye-steric. Kwizifundo kwiiseli ze-HT22, i-CMS-121 ibonise imiphumo ebalulekileyo ye-neuroprotective, ikhusela ngokufanelekileyo ezi seli kwi-ischemia kunye nomonakalo we-oxidative. Ngapha koko, i-CMS-121 ineempawu ezichasene nokudumba, ezibonisa amandla ayo okulungelelanisa iimpendulo ezivuthayo. Ngokwenza njalo, i-CMS-121 inamandla okunciphisa ukuvuvukala kwizicubu ezahlukeneyo kunye nezitho. I-CMS-121 inomsebenzi onamandla we-pharmacological njenge-inhibitor ye-acetyl-CoA carboxylase 1 (ACC1). Impembelelo yayo enamandla yokuthintela kwi-ACC1 iyenza ibe yikhompawundi ethembisayo

Isicelo:

I-CMS-121 (i-CMS121) iyiveli kunye ne-fisetin-based derivative derivative ene-anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.CMS-121 yi-quinolone derivative kunye ne-acetyl-CoA carboxylase 1 (ACC1) esebenzayo ngomlomo. inhibitor eneempawu ezithembisayo ze-pharmacological. Uphando olubanzi luye lwenziwa ukuphanda iingenelo ezinokuthi zenzeke kwi-CMS-121 kwiindawo ezahlukeneyo, kubandakanywa neuroprotection, i-anti-inflammatory effects, umsebenzi we-antioxidant, kunye nefuthe lawo kumakishi ahambelana nokuguga okunempilo.