Igama lemveliso:J-147 Umgubo

Elinye Igama:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147, J147

Inombolo yeCAS:1146963-51-0

Isivavanyi: 99.0%Miz

Umbala: Umgubo omhlophe

Ukupakisha: 25kgs Igubu

J-147i-neuroprotectant enamandla kakhulu ngomlomo ephuma ngokuyinhloko kwi-curcumin, isithako esisebenzayo kwi-turmeric. Ngokungafaniyo ne-curcumin, inqumla umqobo wegazi-ingqondo ngempumelelo kakhulu.

I-J-147 yinto enamandla kakhulu, esebenzayo ngomlomo, i-neuroprotective agent yokuphucula ingqondo.
I-J-147 inokudlula ngokukhawuleza umqobo wengqondo yegazi (BBB). I-J-147 inokuthintela i-monoamine oxidase B (MAO B) kunye ne-dopamine transporter enexabiso le-EC50 le-1.88 μM kunye ne-0.649 μM, ngokulandelanayo. I-J-147 inamandla onyango lwe-Alzheimer's disease

I-J-147 yi-neuroprotectant enamandla kakhulu yomlomo ephuma ngokuyinhloko kwi-curcumin, isithako esisebenzayo kwi-turmeric. Ngokungafaniyo ne-curcumin, inqumla umqobo wegazi-ingqondo ngempumelelo kakhulu. Phakathi kwabo, i-J-147 isebenza ngokubophelela kwi-ATP synthase. Ukuvelisa ngokugqithisileyo kwe-ATP kunxulunyaniswa nenkqubo yokuguga. Ukongeza kumanqanaba okunyusa ama-neurotransmitters NGF kunye ne-BDNF, i-J-147 inokulawula oku. Ukongeza, i-J-147 inqanda i-monoamine oxidase B kunye ne-dopamine transporter. Ukukhuthaza ukukhula kwengqondo ngokunyusa amanqanaba e-nerve growth factor (NGF) kunye ne-brain-derived neurotrophic factor (BDNF). Okona kubaluleke kakhulu, i-J-147 inokukhuthaza ukukhula kweeseli zemithambo-luvo entsha, iphucule amandla okufunda engqondo kunye nenkumbulo, kunye nokuphucula ukusebenza kwengqondo.

Umsebenzi:

I-J-147 inokudlula ngokukhawuleza umqobo wengqondo yegazi (BBB).
I-J-147 inokuthintela i-monoamine oxidase B (MAO B) kunye ne-dopamine transporter enexabiso le-EC50 le-1.88 μM kunye ne-0.649 μM, ngokulandelanayo.
I-J-147 inamandla onyango lwe-Alzheimer's disease (AD).
I-J-147 inamandla onyango lwe-Alzheimer's disease (AD).

Isicelo:

I-J-147 i-synthetic compound egama layo liphambili libandakanya ukuphuculwa kwe-mitochondrial, ngaloo ndlela kuphuculwe ukuveliswa kwamandla kwinqanaba leselula. I-J-147 yenzelwe ukukhulisa amandla engqondo okuzilungisa nokuzikhusela kumonakalo onxulumene nobudala ngokuphucula ukusebenza kwe-mitochondrial. Ukongezelela, i-J-147 ibonisa iimpawu ezibalulekileyo zokulwa nokuvuvukala kunye ne-antioxidant, iqhubela phambili ukuphucula iziphumo zayo ze-neuroprotective. I-J-147 inokukhuthaza ukukhula kweeseli zemithambo-luvo entsha, iphucule ikhono lokufunda kwengqondo kunye nenkumbulo, kunye nokuphucula ukusebenza kwengqondo.