Igama lemveliso:Evodiamine

Elinye Igama:Evodiamine, Isoevodiamine, (+)-Evodiamine, d-Evodiamine,Fructus Evodiae Extract

Inombolo yeCAS:518-17-2

Isivavanyi: 98%Mis

Umbala: Umgubo wekristale otyheli okhanyayo

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

I-Evodiamine yi-alkaloid ekhethekileyo ye-bioactive kunye neyona nto iphambili ye-bioactive kumayeza emveli aseTshayina. Ifunyenwe kumaqunube esityalo se-Evodia evodia, esikhula ngokuyinhloko e-China naseKorea.I-Evodiamine i-alkaloid ye-bioactive ekhethekileyo kunye neyona nto iphambili ye-bioactive kwiyeza zesiNtu zaseTshayina. Ifunyenwe kumaqunube esityalo se-Evodia evodia, esikhula ngokuyinhloko e-China naseKorea. Esi sityalo sityebileyo kwiikhemikhali ezahlukeneyo kwaye besisetyenziswa ngokwesiko kumayeza emveli aseTshayina ukunyanga iingxaki ezahlukeneyo zempilo, kubandakanya ukuphazamiseka kokutya, ukudumba, kunye neentlungu. I-Evodiamine isebenza ngokujolisa kwiindlela ezahlukeneyo zeemolekyuli emzimbeni. Kuyaziwa ngokuvuselela i-vanillin receptors, edlala indima ebalulekileyo ekuboneni intlungu kunye ne-thermogenesis. Ukongezelela, kufunyaniswe ukusebenzisana ne-serotonin kunye ne-dopamine receptors, ebonisa ukuba ineempawu zokuphucula isimo sengqondo.

Umsebenzi webhayoloji: I-Evodiamine yi-alkaloid esecaleni kwisiqhamo seBentham, enemisebenzi eyahlukeneyo yebhayoloji efana ne-anti-inflammatory, anti-obesity, kunye ne-anti-tumor. I-In vitro: I-Evodiamine ibonise i-cytotoxicity ngokuchasene nemigca yeeseli zomhlaza womntu ngokubangela i-apoptosis. Ukongezelela, yindalo ejoliswe kwi-anti-tumor molekyuli eyenza umsebenzi wokulwa ne-tumor ngokusebenzisa iindlela ezahlukeneyo ze-molecular ezifana ne-caspase exhomekeke kunye neendlela ezingaxhomekekanga, indlela ye-sphingomyelin, i-calcium / JNK signaling, i-31 PI3K / Akt / caspase, kunye ne-Fas. -L/. NF – κ B indlela yomqondiso 32 [1]. Kwi-vivo: I-Evodiamine inqanda i-metabolism ye-dapoxetine. Xa kuthelekiswa neqela lokulawula, i-t1 / 2, i-AUC (0- ∞), kunye ne-Tmax pharmacokinetic parameters ye-dapoxetine kwiqela le-evodiamine yanda kakhulu nge-63.3%, 44.8%, kunye ne-50.4%, ngokulandelanayo. Ukongezelela, i-evodiamine yanciphisa kakhulu i-t1 / 2 i-pharmacokinetic parameters kunye ne-AUC (0- ∞) ye-demethylated dapoxetine [2]. I-Evodiamine inqanda ukukhula kwethumba kwimodeli engaphantsi kwe-H22 ye-xenograft. I-Evodiamine ithoba i-VEGF eyenziwe i-angiogenesis kwi-vivo.

I-In vitro: I-Evodiamine ibonisa i-cytotoxicity ngokuchasene nemigca yeeseli zomhlaza womntu ngokudala i-apoptosis. Ukongezelela, yindalo ejoliswe kwi-anti-tumor molekyuli eyenza umsebenzi wokulwa ne-tumor ngokusebenzisa iindlela ezahlukeneyo ze-molecular ezifana ne-caspase exhomekeke kunye neendlela ezingaxhomekekanga, indlela ye-sphingomyelin, i-calcium / JNK signaling, i-31 PI3K / Akt / caspase, kunye ne-Fas. -L/. NF – κ B indlela yomqondiso 32 [1].

Kwi-vivo: I-Evodiamine inqanda i-metabolism ye-dapoxetine. Xa kuthelekiswa neqela lokulawula, i-t1 / 2, i-AUC (0- ∞), kunye ne-Tmax pharmacokinetic parameters ye-dapoxetine kwiqela le-evodiamine yanda kakhulu nge-63.3%, 44.8%, kunye ne-50.4%, ngokulandelanayo. Ukongezelela, i-evodiamine yanciphisa kakhulu i-t1 / 2 i-pharmacokinetic parameters kunye ne-AUC (0- ∞) ye-demethylated dapoxetine [2]. I-Evodiamine inqanda ukukhula kwethumba kwimodeli engaphantsi kwe-H22 ye-xenograft. I-Evodiamine ithoba i-VEGF eyenziwe i-angiogenesis kwi-vivo.

UMSEBENZI:

I-anti-inflammatory, anti-tumor, kunye nemisebenzi ye-hypoglycemic ineempembelelo ezithile zonyango kunyango lwe-dementia yokuqala kunye ne-stroke.Ine-analgesic, inciphisa uxinzelelo lwegazi kwaye ibangele ukunyuka okukhulu kwefuthe lobushushu bomzimba. Isixhobo seklinikhi sale mveliso kukuvelisa iiarhente zonyango kwi-diuretics kunye nokubila.

1. Isicatshulwa se-Evodia sisetyenziselwa ukunyanga iimpawu zokukhathazeka kwesisu. Ezi ziquka isicaphucaphu, ukuhlanza, kunye norhudo. Kuthiwa kusebenza ngokukodwa ekuphatheni isifo sohudo sasekuseni.

2. I-Evodia isetyenziselwa ukuvuselela umdla kunye nokunyanga iimpawu zesisu ezinxulumene nokungabikho komdla ekudleni.

3. Isicatshulwa se-Evodia sine-anti-inflammatory, anti-tumor, anti-viral, astringent, kunye ne-diuretic properties.

4. I-Evodiamine ene-analgesia, ukunciphisa uxinzelelo lwegazi kunye nokunyuka kobushushu bomzimba kunye nezinye iziphumo ze-pharmacological.

5. I-Evodiamine inesisu, ukuyeka ukubuyisela, i-oxyrygmia effect kunye ne-diuretic effect.

I-6.I-Evodiamine inempembelelo enamandla yokuthintela kwi-li; kunye nempembelelo ebalulekileyo ye-insecticidal kwi-ascarissuum;

7.I-Evodiamine nayo inokucutha isibeleko kwaye inyuse uxinzelelo.

8.Besides, i-evodiamine nayo inefuthe elihle kwi-Alzheimer's disease kunye ne-stroke.

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