Neohesperidin Dihydrochalcone (NHDC)

I-NHDC ekwimo esulungekileyo ifumaneka njengento emhlophe engafaniyoiswekile engumgubo.

Ikhompawundi emalunga ne-1500-1800 amaxesha amnandi kuneswekile kwimiba ephakathi;malunga 340 amaxesha amnandi kuneswekile ubunzima-for-ubunzima.Amandla ayo achaphazeleka ngokwendalo ngezinto ezifana nesicelo esisetyenziswa kuyo, kunye nepHyemveliso.

Njengezinye eziswiti kakhuluglycosides, njengeglycyrrhizinkunye nabo bafunyenwe kuyostevia, incasa eswiti ye-NHDC iqala kancinci kuneswekile kwaye ihlala emlonyeni kangangexesha elithile.

Ngokungafaniyoiaspartame, I-NHDC izinzile kumaqondo okushisa aphakamileyo kunye ne-acidic okanye iimeko ezisisiseko, kwaye ngoko ingasetyenziselwa izicelo ezifuna ixesha elide leshelufu.I-NHDC ngokwayo ingahlala ikhuselekile ekutyeni ukuya kutsho kwiminyaka emihlanu xa igcinwe kwiimeko ezifanelekileyo.

Imveliso iyaziwa ngokuba nefuthe elinamandla le-synergistic xa isetyenziswe kunye nezinyeizimuncumuncu ezenziweyonjengeiaspartame, saccharin, acesulfame potassium, kwayecyclamate, kunye notywala beswekile njengeixylitol.Ukusetyenziswa kwe-NHDC konyusa iziphumo zezi zimuncumuncu kwiindawo ezisezantsi kunokuba bekuya kufuneka;Izixa ezincinci zezinye izimuncumuncu ziyafuneka.Oku kubonelela ngenzuzo yeendleko.

Yintoni iNeohesperidin dihydrochalcone?

I-Neohesperidin dihydrochalcone powder, eyaziwa nangokuthi i-Neohesperidin DC, i-Neo-DHC kunye ne-NHDC emfutshane, i-sweetener ephuculweyo eveliswa yi-neohesperidin.I-NHDC ithathwa njenge-sweetener ephezulu, engenazo izondlo kunye nencasa emnandi;inokuphucula ubumnandi kunye nomgangatho weeresiphi zokutya ezahlukeneyo.

I-Neohesperidin dihydrochalcone yikhompawundi emalunga ne-1500-1800 yamaxesha amnandi kuneswekile kwindawo yoxinzelelo kwaye inobunzima obuphindwe ka-340 kuneswekile.

I-Neohesperidin dihydrochalcone idla ngokusetyenziswa kumashishini ezongezo zokutya kunye nesongezo sokutya.

Fumana kunye nomthombo weNeohesperidin dihydrochalcone

I-Neohesperidin dihydrochalcone yafunyanwa ngo-1960 njengenxalenye yeSebe lase-US leprojekthi yophando lwezolimo ukufumana iindlela zokunciphisa ubukrakra kwijusi yesitrasi.I-Neohesperidin licandelo elikrakra elikhoyo kwi-peel kunye ne-pulp ye-orenji ekrakra kunye nezinye iziqhamo ze-citrus;ikwasisithako esisebenzayo se-flavonoid sesiqhamo se-citrus aurantium.Xa iphathwa nge-potassium hydroxide okanye enye isiseko esomeleleyo, kwaye emva koko i-hydrogenated, iba yi-Neohesperidin dihydrochalcone (NHDC).

I-NHDC ayenzeki kwindalo.

I-Neo-DHC i-hydrogenated ukusuka kwi-neohesperidin yendalo-umthombo wendalo, kodwa yafumana ukuguqulwa kweekhemikhali, ngoko akusiyo imveliso yendalo.

Neohesperidin dihydrochalcone VS ezinye izimuncumuncu

Ubumnandi obahlukeneyo kunye nencasa

Xa kuthelekiswa ne-sucrose, i-neohesperidin DC imalunga ne-1500-1800 amaxesha amnandi kuneswekile kunye namaxesha angama-1,000 amnandi kune-sucrose, ngelixa i-sucralose ngamaxesha angama-400-800 kunye ne-ace-k ngama-200 amnandi kuneswekile.

I-Neohesperidin DC incasa ngokucocekileyo kwaye inencasa ezinde.Njengezinye ii-glycosides ezinoshukela ophezulu, ezifana ne-glycyrrhizin efumaneka kwi-stevia kunye nezo zisuka kwingcambu ye-licorice, i-NHDC's sweet iqala kancinci kuneswekile kwaye ihlala emlonyeni ixesha elide.

Ukuzinza okulungileyo kunye nokhuseleko oluphezulu

I-NHDC izinzile phantsi kobushushu obuphezulu, iimeko ze-acidic okanye i-alkaline kwaye ngoko ingasetyenziselwa izicelo ezifuna ixesha elide leshelufu.I-NHDC inokugcina ukutya kukhuselekile ukuya kutsho kwiminyaka emihlanu phantsi kweemeko ezifanelekileyo

Ii-receptors ezahlukeneyo

Umbono womntu wobumnandi kunye nokunambitha ulungelelwaniswa yi-T1Rs, intsapho yokuqala ye-GPCRs, i-TIRs ibonakaliswe kwi-gustatory ye-palate ethambileyo kunye nolwimi, kuquka i-TIR1, i-T1R2, kunye ne-TIR3, ehlala ifumaneka ngendlela ye-dimers.I-dimer T1R1-TIR3 yi-receptor ye-amino acid, evakalisa kwaye ithatha inxaxheba ekuqapheliseni ukunambitha.I-dimer T1R2-T1R3 yi-receptor emnandi, ethatha inxaxheba ekuqapheliseni i-sweet taste.

I-sweeteners efana ne-sucrose, i-aspartame, i-saccharin, kunye nomsebenzi we-cyclamate kwi-extracellular structure region ye-T1R2.I-NHDC kunye ne-cyclamate isenzo kwi-transmembrane inxalenye ye-T1R3 ukuvelisa ubumnandi.I-Neohesperidin DC inxibelelana neentsalela ze-amino acid ezithile kwingingqi ye-transmembrane ye-T1R3 ukuphembelela ubumnandi bayo kwaye kwangaxeshanye, inokuphembelela isiphumo se-synergistic sobumnandi be-dimer T1R2-T1R3.Njenge-sweetener, i-NHDC inesiphumo esibalulekileyo sokuswiti xa idityaniswe nezinye izimuncumuncu ezinenani elincinci lezithako.

Ngaphandle koko, iNeohesperidin DC iyahluka kwizimuncumuncu zemveli kwimisebenzi yayo yokwenza iswiti, ukunyusa ivumba, ukufihla ubukrakra, kunye nokuguqulwa kwencasa.

Izibonelelo kunye nokusetyenziswa okunokwenzeka kwe-neohesperidin dihydrochalcone (NHDC)

Iipropati ze-Antioxidant

Kwiminyaka yakutshanje, uphando oluninzi lubonisa ukuba i-neohesperidin dihydrochalcone inomsebenzi obalulekileyo oxhomekeke kugxininiso kwi-radicals yamahhala kunye neentlobo ze-oxygen esebenzayo (ROS).Ngokukodwa, i-NHDC ineyona mpembelelo inamandla yokuthintela kwi-H2O2 kunye ne-HOCl.(umlinganiselo wokulahla we-HOCl kunye ne-H2O2 yayingu-93.5% kunye ne-73.5% ngokulandelanayo)

Ngaphezu koko, i-NHDC inokuthintela ukonakaliswa kweproteni kunye nokuqhekeka kwe-plasmid DNA strand, kwaye ikhusele i-HIT-T15, i-HUVEC yokufa kweseli kuhlaselo lwe-HOCl.

I-NHDC inomsebenzi owahlukileyo we-antioxidant ngokuchasene neeradicals zasimahla.Umsebenzi we-antioxidant we-NHDC ukwaquka ukuba unokuthintela ngokuyinxenye isiphumo esimdaka se-pigment deposition ebangelwa yi-polyphenol oxidase, enokuthintela ngokubalulekileyo ukulawulwa kwe-matrix metalloproteinase (MMP-1) eyenziwa yimitha ye-infrared, ngaloo ndlela ikhusela ulusu lomntu ukuguga ngaphambi kwexesha ngenxa yokuvezwa kwimitha ye-infrared.

Isicelo: I-NHDC inokuba yinto enokuchasana ne-browning kunye ne-agent emhlophe

Iswekile yegazi esezantsi kunye neCholesterol esezantsi

I-NHDC yinto esebenzayo, engeyiyo ityhefu, enekhalori esezantsi isweetener esanelisa isidingo sabantu sobumnandi kwaye ngoko yehlisa ukutyiwa kweswekile.

Uphononongo lwakutsha nje lubonise ukuba i-NHDC inokuthintela i-α-amylase kwizilwanyana ezanyisayo ngamaqondo ahlukeneyo kwaye emva koko inciphise ukufunxwa komzimba kweswekile, ngaloo ndlela inciphisa iswekile yegazi emzimbeni, ebaluleke kakhulu kumayeza, ngakumbi kwizigulane ezineswekile.

Isicelo: I-NHDC ingasetyenziswa njenge-sweetener engenaswekile, i-calorie-free.Xa isetyenziswe ngokufanelekileyo, inokuthatha indawo ye-sucrose kwaye yehlise ukuthathwa kwe-sucrose yabantu.Ilungele abantu abatyebe kakhulu nabangatyebangayo.

Khusela isibindi

UZhang Shuo et al.ifumene ukuba i-NHDC inokunciphisa amanqanaba e-ALT, i-AST kwi-serum kunye ne-hydroxyproline kwizicubu zesibindi zeegundane ezine-fibrosis ezibangelwa yi-CCI, kwaye zibuye zicothe ukuhla kunye necrosis yeeseli kunye ne-fibrosis yesibindi kwiidigri ezahlukeneyo.Ngaphezu koko, ukuncipha kwe-ALT kunye ne-AST kwi-serum kunokuphucula i-lipid metabolism kunye nokusebenza kwesibindi, ukuvimbela ukubunjwa kwesibindi esinamafutha kunye ne-endothelial plaque kwi-arteries eziphambili.

Ngaphandle koko, i-NHDC inokunciphisa ngokufanelekileyo umonakalo owenziwe yi-CC1, ukunciphisa ukuvuvukala, kunye ne-cell apoptosis.

Isicelo: I-NHDC inethemba lokusetyenziswa njenge-hepatoprotective agent.

Thintela isilonda esiswini

I-NHDC inokuthintela ukukhutshwa kwe-asidi ye-gastric, ngoko ingasetyenziselwa njenge-antacid ukuxuba i-Aluminium Hydroxide Gel okanye ezinye ii-agent eziqhelekileyo zokwenza i-asidi yokuphucula ukuxhathisa kwe-asidi yesisu samva.

Suhrez et al.ifumanise ukuba i-NHDC inokunciphisa kakhulu isalathiso sesilonda esibangelwa kuxinzelelo loxinzelelo olubandayo (CRS).Umsebenzi wayo ufana ne-ranitidine, enokuthintela umsebenzi we-histamine kunye nokunciphisa kakhulu ukukhutshwa kwe-asidi yesisu kunye ne-pepsin.

Isicelo: I-NHDC inokuba yinto entsha ekrwada yeyeza lesisu.

Ukulawula i-immunity

I-NHDC yongezwa ekutyeni njenge-sweetener, kungekhona nje ngenxa yokunambitheka okumnandi kunye nokunyanzeliswa kwezilwanyana, kodwa nangenxa yempembelelo yayo yeprobiotic efunyenwe nguDaly et al.Xa i-NHDC yongezwa kwisondlo samantshontsho, i-Lactobacillus ekungeneni kwe-caecum yeehagu yanda kakhulu ngokunyuka kwe-lactic acid concentration kwi-intestinal cavity.Inokuchaphazela i-symbiotic intestinal flora, ilawula ukukhuseleka komzimba, kunye nokunciphisa izifo zamathumbu.

Isicelo: I-Neohesperidin DC ingasetyenziselwa njengesongezo sokutya, i-NHDC iphucula ukuthandeka kwezinto zokutya, ukwandisa ukutya kwezilwanyana, kunye nokuphucula ibhaktheriya yamathumbu, emva koko ivuselela ukukhula kwabo.

Neohesperidin DC ukhuseleko

I-NHDC asiyocarious, non-fermentative sweetener.Uphando lobungcali malunga nobutyhefu olwenziwayo.Imetabolism ye-NHDC kumzimba womntu iyafana neyezinye zendalo ze-flavonoid glycosides.I-NHDC inometabolism okhawulezayo, akukho vuselelo kumzimba womntu, kwaye akukho ziphumo bezingalindelekanga eziyityhefu.

I-Neo-DHC igcinwe kwi-Pharmacopoeia yaseYurophu kwiminyaka engamashumi amabini eyadlulayo kwaye yamkelwa njenge-sweetener yi-European Union, kodwa hayi yi-FDA.E-United States, i-neo-DHC ivunyiwe ukuba isetyenziswe kuphela njengesiphuculi sencasa.Ngaphandle koko, ukubhaliswa kwe-NHDC kwimeko ye-GRAS kwi-FDA kusendleleni.

I-Neohesperidin dihydrochalcone (NHDC) ecetyiswayo idosi kunye neziphumo ezibi.

Ukulungiselela izimuncumuncu kunye neemveliso zobisi, umthamo: 10-35 ppm (i-sweetener), 1-5 ppm(incasa yencasa)

Ukwenzela ukuMasking ubukrakra boPhando, idosi: 10-30 ppm( isweetener), 1-5 ppm(incasa yencasa)

Ukufumana i-flavour feed, i-dose ephezulu ephakanyisiweyo: 30-35 mg NHDC / kg feed epheleleyo, 5 mg NHDC / L amanzi;3-8 mg NHDC/L amanzi okufunxa kunye nokulunyulwa

Iinjongo ezahlukeneyo zigqiba umthamo.

Nangona kunjalo, ukuba ithathwa ngokugqithisileyo, nayiphi na isithako sinokubeka umngcipheko kumzimba womntu.Ucwaningo luye lwabonisa ukuba i-neohesperidin dihydrochalcone (NHDC) inokubangela isicaphucaphu kunye ne-migraine xa i-concentration i malunga ne-20 ppm okanye ngaphezulu.Kuyacetyiswa ukuba unxibe iimaski zotyando xa usebenza ne-NHDC esulungekileyo

Isatifiketi sokuHlalutya