Igama lemveliso:Nicotinamide riboside chloride powder
Elinye igama:3-(Aminocarbonyl)-1-PD-ribofuranosyl-pyridinium chloride(1:1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;I-NR, i-vitamin NR; i-Niagen, i-TRU NIAGEN
CASNO: 23111-00-4
Ifomula yemolekyuli: C11H15N2O5.Cl
Ubunzima beMolekyuli: 90.70 g / mol
Ubunyulu:98%
Indawo yokunyibilika:115℃-125℃
Imbonakalo:KuMhlophe ukuya kuMbuphu oMthubi oMthubi
Ukusetyenziswa: Yonyusa amanqanaba e-NAD +, Ixhasa ukwaluphala okunempilo kunye nengqondo / ingqondo
Izicelo:njengesongezelelo sokutya, ukutya okusebenzayo, kunye neziselo
Idosi ecetyiswayo: hayi ngaphezulu kwe-180 mg / ngosuku
I-Nicotinamide riboside luhlobo olusanda kuthakazelelwa lweVithamini B3, eneempawu ezizodwa;singaphambili esisesikweni se-NAD+.
I-Nicotinamide riboside (NR), eyaqala ukuchazwa kwi-1944 njengento yokukhula (i-Factor V) ye-Haemophilus influenza, kunye ne-1951, i-NR, yaqala ukuphandwa njenge-metabolism kwi-tissue ye-mammalian.
Njengoko unokubona ukuba, kukho iindlela ezimbini ze-NR ezikhoyo, enye yiNicotinamide Riboside, kwaye enye yiNicotinamide Riboside chloride.
Ukuthetha ngamachiza, zizinto ezimbini ezihluke ngokupheleleyo kuba zineenombolo ezahlukeneyo ze-CAS, i-NR kunye ne-1341-23-7 ngelixa i-NR chloride kunye ne-23111-00-4.I-NR ayizinzile kwiqondo lokushisa, ngelixa i-NR chloride izinzile.I-Brand eyaziwayo enelungelo elilodwa lomenzi ebizwa ngokuba yi-NIAGEN®, ekhutshwe yiChromadex Inc ngo-2013, luhlobo lweNicotinamide riboside chloride, ejonge ukubuyisela umva iimpawu zokuguga ngaphakathi emzimbeni wakho.I-Nicotinamide Riboside eyenziwe kwi-Cima Science nayo ikwifom ye-chloride powder.Ukuba ayichazwanga, i-NR iya kubhekisa kwifom ye-NR chloride kwinqaku elingezantsi.
Imithombo yokutya yeNicotinamide riboside
Ubungakanani be-NR ekutyeni ngumzuzu, xa kuthelekiswa nesongezo sesondlo.Nangona kunjalo, yeyiphi eyona mithombo yokutya iphambili ene-nicotinamide riboside (NR)?
Ubisi lwenkomo
Ubisi lwenkomo ludla ngokuba ne-12 μmol NAD(+) precursor vithamini/L, apho i-60% yayikhona njenge-nicotinamide, kwaye i-40% yayingoku njenge-NR.(Ubisi oluqhelekileyo luqulethe i-NR ngaphezu kobisi oluphilayo), isifundo esipapashwe yiYunivesithi yase-Iowa, kwi-2016
Igwele
Uphononongo oludala luye lwathi, "Into enye ethintelayo yahlukaniswa negwele kwaye yafunyanwa iyi-nicotinamide riboside, inokuba ivela kwi-NAD (P) ngexesha lokulungiswa kwezicatshulwa zegwele, okanye kwizongezo zegwele lokutya ngexesha lokugaya kwi-vivo."Nangona kungekho datha yobuninzi kwigwele
Ibhiya
Ubhiya unomlinganiselo ofanelekileyo we-carbs kunye nokusela abo bakwimo ye-liquid njengaleyo kuya kuba nefuthe le-glycemic;amaphepha ophando ohlukeneyo akhankanye ibhiya njengomthombo wokutya we-nicotinamide riboside.
Kwakhona, kunokubakho amanani omkhondo we-NR njengeprotein ye-whey, amakhowa, njl.
Kubantu abaninzi, ubisi luvaliwe ngenxa yezinye izizathu.Imithombo yokutya ye-nicotinamide riboside inokuba luncedo, kodwa ayisebenzi kangako kunesongezo se-NR.
Kutheni iNicotinamide Riboside (NR) ichaza njengeyenyani ye-NAD+ eyandulela i-vitamin invertebrates?
Kukho iindlela ezintlanu zokucinga ezixhasayo:
I-Haemophilus influenza, ibhaktiriya ebangela umkhuhlane, engenandlela ye-de novo kwaye ayikwazi ukusebenzisa i-Na okanye i-Nam, ixhomekeke ngokungqongqo kwi-NR, i-NMN, okanye i-NAD+ yokukhula kwi-bloodstream ye-host.
Ubisi ngumthombo we-NR.
I-NR ikhusela i-murine DRG neurons kwi-ex vivo axonopathy assay ngokusebenzisa i-transcriptional induction ye-nicotinamide riboside kinase (NRK) i-2 gene.
I-NR eyongezwe ngokungaqhelekanga kunye nezinto eziphuma kuzo zonyusa uqokelelo lwe-NAD+ ngendlela exhomekeke kwithamo kwimigca yeeseli zabantu.
I-Candida glabrata, i-fungus engenelelayo exhomekeke kwi-NAD+ ye-precursor yevithamini ekukhuleni, isebenzisa i-NR ngexesha lokusasazwa kosulelo.
Nicotinamide Riboside VS Nicotinamide VS Niacin
I-Niacin (okanye i-nicotinic acid), i-organic compound kunye nefom ye-vitamin B3, isondlo esibalulekileyo somntu.Inefomula ethi C6H5NO2.
INicotinamide okanye ebizwa ngokuba yiniacinamide luhlobo lwevithamin B3 efumaneka ekutyeni kwaye isetyenziswa njengesongezelelo sokutya kunye namayeza.Inefomula ethi C6H6N2O.
INicotinamide riboside luhlobo lwe-pyridine-nucleoside yevithamin B3 esebenza njenge-precursor ye-nicotinamide adenine dinucleotide okanye i-NAD+.Inefomula ethi C11H15N2O5+.
IiNzuzo zeMpilo yeNicotinamide Riboside
INicotinamide Riboside inceda ukuveliswa kwamandla
Kwizilwanyana, ukuxhaswa kwe-NR kunciphise ukusetyenziswa kwe-NAD, okuye kwaphucula ukusebenza kwe-mitochondrial, ukubuyisela ngokukhawuleza ubunzima bemisipha, kunye nokugcina amandla amanqanaba e-NAD kunye nomthamo wokuzivocavoca kwiigundane ezindala, ukunceda ukugcina ubunzima bemisipha kunye nomsebenzi, ukuxhasa ukuveliswa kwamandla amaninzi.
INicotinamide Riboside iphucula umsebenzi wokuqonda
I-NR igcina iiseli ze-nerve kwingqondo ngokuvula i-SIRT3, i-Supplementation ivuselela iindlela ze-NAD kwaye inceda ukukhusela ukuguqulwa kwengqondo.
I-NR yongeze umsebenzi wokuqonda kwaye yacotha ukuqhubeka kwesifo se-Alzheimer kwiimpuku ezinikwe i-NR iinyanga ezintathu.
INicotinamide Riboside ikhusela ukungeva
Ngokuvula indlela ye-SIRT3, uphononongo lwe-UNC lufumanise ukuba luncede ukukhusela iimpuku ngokuchasene nokungeva okubangelwa yingxolo.
INicotinamide Riboside ikhusela isibindi
Ukuthatyathwa kwe-NR ngomlomo kwandisa i-NAD emzimbeni, enceda ukukhusela isibindi.I-NR yayeka ukuqokelelwa kwamafutha, yehlisa uxinzelelo lwe-oxidative, ithintele ukudumba, kunye nokuphucula uvakalelo lwe-insulin kwisibindi seempuku.
Ngaphaya koko, i-NR inokwandisa ubomi obude, Yonyusa imetabolism, ixhasa umlo ochasene nomhlaza, inciphisa iimpawu zesifo seswekile, yonyusa imetabolism, inokunceda ekunciphiseni ubunzima.
Ngaba iNicotinamide Riboside ikhuselekile?
Ewe, i-NR ikhuselekile.
I-NR ineemvavanyo ezintathu zeklinikhi ezipapashiweyo eziqinisekisa ukuba ikhuselekile ukuba isetyenziswe ngabantu.
Ukuhlalutya ngononophelo kwaye kugxininise lonke ulwazi lwangaphambili kunye nolwazi lwekliniki olukhoyo kwi-NR luqinisekisa ukuba lukhuselekile kwaye lunyamezeleke kakuhle.
I-Niagen ikhuselekile kwaye i-GRAS, isebenzisa iinkqubo zesayensi, phantsi kwe-Federal Food, Drug, and Cosmetic Act (FFDCA).
Uvavanyo lwabantu lweNicotinamide Riboside
Maninzi amaphononongo aphambi koklinikhi athe aqhutywa uvavanyo lwe-NR kwiinkqubo ezahlukeneyo zemodeli.
Ngo-2015, izifundo zokuqala zeklinikhi zabantu zagqitywa, kwaye iziphumo zabonisa ukuba i-NR ngokukhuselekileyo nangempumelelo yonyusa amanqanaba e-NAD kumavolontiya abantu abasempilweni.
Ulingo lweklinikhi olulawulwa yi-placebo lwe-nicotinamide riboside kumadoda atyebe ngokugqithiseleyo ngokungenamkhethe: ukhuseleko, uvakalelo lwe-insulin, kunye neziphumo ze-lipid-mobilizing.
-Ipapashwe kwiAmerican / Journal of Clinical Nutrition
Iziphumo: I-12 wk ye-NR yokuncedisa kwi-dose ye-2000 mg / d ibonakala ikhuselekile, kodwa ayiphuculi ukuvakalelwa kwe-insulin kunye nomzimba wonke we-glucose metabolism kwi-obese, i-insulin-resistant men.
Ukuxhaswa okungapheliyo kwe-nicotinamide riboside kunyanyezelwe kakuhle kwaye kuphakamisa i-NAD + kubantu abasempilweni abakwiminyaka ephakathi kunye nabadala.
–Ipapashiwe kuNxibelelwano lweNdalo
INicotinamide Riboside Ingakumbi kwaye ngomlomo iBioavailable kwiMice naseBantu.
–Ipapashiwe kuNxibelelwano lweNdalo
Apha sichaza ixesha kunye neziphumo ezixhomekeke kumthamo we-NR kwi-metabolism yegazi ye-NAD ebantwini.Ingxelo ibonisa ukuba igazi lomntu i-NAD inokunyuka ukuya kuthi ga kwi-2.7-fold kunye nedosi yomlomo enye ye-NR kuphando lolingo lomntu omnye kwaye i-NR yomlomo iphakamisa i-NAD ye-hepatic ye-mouse nge-pharm ebonakalayo kunye nephezulu.
