I-Phosphatidylcholine iqukethe "intloko" ye-choline kunye ne-glycerol phospholipids.Umsila we-glycerol phospholipids unokuba yintlobo ye-fatty acids.Ngokuqhelekileyo, umsila omnye ugcwele i-asidi enamafutha, enye i-asidi enamafutha angaxutywanga.Kodwa ezinye zazo zombini ziiasidi ezinamafutha angaxutywanga.Ngokomzekelo, i-phosphatidylcholine yezilwanyana imiphunga inomlinganiselo ophezulu we-dipalmitoyl phosphatidylcholine.
Igama lemveliso: Phosphatidylcholine PC
Elinye Igama: 1,2-diacyl-sn-glycero-3-phosphocholine, PC
Inkcazo yeMveliso: Ulwelo / okanye i-waxy eqinileyo: malunga ne-60%
Umgubo / igranule: 10% - 98%,Iimpawu ezidumileyo 20%, 50%, 98%
Isampulu yasimahla :Iyafumaneka
Imbonakalo: Umgubo omthubi okhanyayo okanye omthubi, i-oyile okanye i-waxy eqinileyo
Indlela yoVavanyo:HPLC
Ubomi beShelf: iminyaka emi-2
I-Phosphatidylcholine iqukethe "intloko" ye-choline kunye ne-glycerol phospholipids.Umsila we-glycerol phospholipids unokuba yintlobo ye-fatty acids.Ngokuqhelekileyo, umsila omnye ugcwele i-asidi enamafutha, enye i-asidi enamafutha angaxutywanga.Kodwa ezinye zazo zombini ziiasidi ezinamafutha angaxutywanga.Ngokomzekelo, i-phosphatidylcholine yezilwanyana imiphunga inomlinganiselo ophezulu we-dipalmitoyl phosphatidylcholine.
I-Phosphatidylcholine iyona nxalenye ephambili ye-biofilms.Umthombo ulula kakhulu kwaye ubanzi.Unokufumana i-phosphatidylcholine phantse nakuphi na ukutya ebomini bakho, kungekhona nje i-yolk yeqanda okanye i-soya.Ikwayilecithin kumafutha ezilwanyana.Unokufumana i-phosphatidylcholine kwizicubu zezityalo kunye nezilwanyana.Ngokuqinisekileyo, ukuveliswa kwezorhwebo kwe-phosphatidylcholine yimveliso ecocekileyo enomxholo ophezulu kunye nefuthe elithe ngqo.
I-Phosphatidylcholine yi-lipophilic hydrophilic substance;i-alcohol ephantsi e-soluble kwi-C1 ukuya kwi-C4, i-insoluble kwi-acetone namanzi.
Nangona iiPC zisetyenziselwa ukuxhasa impilo yengqondo, zinokuxhasa ukusebenza kwesibindi kunye nokulawula amanqanaba e-cholesterol.
I-Choline inokuwela umqobo wegazi-ingqondo ngokulula kakhulu ngenkqubo yokusasazwa kwe-unsaturated, kwaye olu tshintsho lweplasma lunokuvelisa utshintsho olufanayo kumanqanaba echoline yobuchopho.
Ngenxa yokuguqulwa okunganeleyo kwenkqubo yokuguqulwa kwe-choline, engagcwaliswanga ngokupheleleyo yi-choline substrate, umxholo we-choline kwi-plasma uyanda, okhuthaza ukubunjwa kwe-acetylcholine kunye ne-phosphorylcholine kunye nokukhululwa kwe-acetylcholine.Ukuba umxholo wezinye ii-precursors ze-phosphatidylcholine zanda, inkqubo yokuguqulwa kwe-choline kwi-phosphatidylcholine kunye nokunyuka komxholo we-peas kwanda.Inqanaba le-synaptic membranes kwingqondo liyanda.I-Choline i-metabolized kwi-betaine kwisibindi, eyona ndlela iphambili yokuhlaziywa kwe-methionine kunye ne-S-adenosylmethionine ukubonelela ngeqela le-methyl.
Uninzi lwemetabolism yesibindi yenzeka kwi-membrane yeseli ethatha i-33,000 yeemitha zesikwere zomzimba womntu.
Kukho iminyaka engaphezu kwe-20 yezilingo zeklinikhi eziboniswe ukuba i-PC ikhusela isibindi kwizinto ezininzi ezinobuthi ezonakalisa iimbumba zeeseli, ezifana nokusela utywala, iziyobisi, ukungcola, iintsholongwane kunye nezinye iziphumo ezinobuthi.
Enye i-surfactant ye-PC iyona nxalenye ephambili ye-membrane yeseli kunye nemiphunga, ehambisa phakathi kwe-membrane yeseli ngeprotheni yokudlulisa i-phosphatidylcholine (PCTP).Ikwadlala indima kwi-membrane-mediated cell signal transduction kunye nokusebenza kwe-PCTP kwezinye ii-enzymes.
Kukho inqaku elibhidayo apha.I-Lecithin ayikho i-phosphatidylcholine.I-Phosphatidylcholine yinxalenye ebalulekileyo ye-lecithin.
Iinzuzo ze-phosphatidylcholine
Khusela isibindi ekwenzakaleni
Ukuphucula ukusebenza kwengqondo
Ukuthintela iziphumo ebezingalindelekanga zamachiza
Isiphumo somlingo esichasayo songezwa kwizinto zokuthambisa
Ukubola kwe-lipid
Ukumelana ne-ulcerative colitis
Ngokwenani elikhulu leemvavanyo zezilwanyana, ukuxhaswa kwe-PC kunokunyusa i-acetylcholine (i-neurotransmitter engqondweni), eyona nto ibalulekileyo yokuphucula imemori.Uphononongo olongezelelweyo luyaqhubeka ukujonga iziphumo zePC kunye nezinye izondlo ekuphuculeni imemori kwiigundane zedementia.Kuyaziwa ukuba i-PC kunye nezinye izondlo zinemiphumo emihle kunye nemiphumo esebenzayo, kodwa iimvavanyo ezininzi ziyafuneka.Ngokunzulu ngakumbi, kwi-2017, kukho izifundo ezihambelanayo kumanqanaba e-phosphatidylcholine kunye nesifo se-Alzheimer.
Isibindi silungu elibalulekileyo kumzimba womntu, kwaye eminye imisebenzi kubomi bemihla ngemihla inokubangela umthwalo omkhulu kwisibindi, esiqhelekileyo kwisibindi esinamafutha kunye ne-cirrhosis.
Ukutya okunamafutha aphezulu kunokuba nefuthe elibi kwisibindi.Kakade ke, isibindi sisenokonakaliswa yityhefu yotywala, iziyobisi, izinto ezingcolisa umzimba, iintsholongwane nezinye izinto eziyityhefu, yaye kunzima ukuyilungisa.Kwiminyaka edlulileyo ye-20 yezilingo zeklinikhi, ukufunyanwa kwe-phosphatidylcholine akuzange kudlale indima ebalulekileyo kwinkqubo yokulondoloza ubomi.Kunokuthiwa isiphumo asanelisi, kodwa njengoko i-sildenafil yayiyilwe ekuqaleni ukwenza ichiza lonyango lwentliziyo, ezinye iziphumo zafunyanwa kwiindawo zesicwangciso solingo.Ngokuhlalutya ngokucophelela, sinokufumanisa umphumo wokukhusela we-PC kwisibindi ngokwe-permeability ye-phosphatidylcholine kunye nefuthe layo lokukhusela kwi-membrane yeseli.Ekubeni ayinakulungiswa, inokukhuselwa kwangaphambili, nayo indima enkulu ye-phosphatidylcholine.
Nangona i-phosphatidylcholine isetyenziswe njengesongezelelo sesondlo sokutya ngomlomo, ayiphazamisi kwiimpawu zayo ezahlukeneyo.Ngokweempawu zayo ezikhethekileyo zomzimba kunye nebhayoloji, inokungena lula eluswini kwaye yandise ukunyanzeliswa kwezinye iimveliso.Ke ngoko, abaninzi abavelisi bazimisele kakhulu ukusebenzisa i-phosphatidylcholine kwiikhrimu zabo zokhathalelo lwesikhumba lwangaphandle ukwenza izikhumba ezigudileyo nezifumileyo.I-Phosphatidylcholine nayo ibonise iziphumo ezigqwesileyo kunyango lwe-acne, kunye nokunciphisa i-70% kwimozulu emva kweentsuku ze-28.
I-Phosphatidylcholine yimolekyuli ebalulekileyo yebhayoloji efumaneka kuyo yonke iseli yomzimba womntu.Ezinye izazinzulu ziye zazama iimpuku eziye zatshintshwa ngokwemfuza ukuze zivelise umonakalo oxidative kwaye zikhawuleze ukuguga ukuze zifunde iziphumo ze-phosphatidylcholine ekugugeni, ukuphuculwa kwengqondo kunye nokuphucula imemori kwizigulane ze-Alzheimer.Ngokuqinisekileyo, ezinye izazinzulu zikholelwa ukuba ukuxhaswa kwe-phosphatidylcholine ukunyanga isifo se-Alzheimer akubonakali ngokwaneleyo.Kodwa isantya sokudala ihlabathi ngaphandle kwe-Alzheimer asinakuyeka.Ngokuqinisekileyo, asikwazi ukukhupha ukuba kunokwenzeka ukuba i-phosphatidylcholine inendima, kodwa sidinga iimvavanyo ezininzi nangaphezulu ukubonisa indima yayo ethile.
Imiphumo emibi ye-phosphatidylcholine
Ikakhulu ibonakaliswe kwinkalo yezonyango, ukutya-i-PC-equlethe iimveliso ezinokuthathwa ngokwemiyalelo;xa isetyenziselwa amayeza, kufuneka ilandele ngokungqongqo imiyalelo yoogqirha kunye nabavelisi beziyobisi ngokusetyenziswa kweziyobisi.Ukuze ugweme le mingcipheko yeziphumo ebezingalindelekanga, ukuqala ngedosi esezantsi enokwenzeka, idosi ephezulu ifumaneka ngokuthe ngcembe.
I-PC yomlomo inokukhokelela ekubileni kakhulu.Ukuthatha ngaphezu kwe-30 grams ngosuku kunokukhokelela kurhudo, isicaphucaphu, okanye ukugabha.
Ukujova i-PC ngokuthe ngqo kwi-fat tumors kunokukhokelela ekuvukeni okukhulu okanye i-fibrosis.Isenokukhokelela kwiintlungu, ukutshisa, ukurhawuzelelwa, ukudumba kwegazi, ukudumba, kunye nokubomvu kolusu
Izongezelelo zePC zingasetyenziswa kwi-capsule kunye nefom ye-liquid ngaphandle komyalelo.Zibhekwa njengekhuselekile xa zisetyenziswe ixesha elifutshane njengoko kuyalelwe.Ukutofwa kwePC kufuneka kulawulwe ngabasebenzi bezempilo.
