I-Beta-nicotinamide Mononucleotide (NMN), imveliso ye-NAMPT yokusabela kunye ne-NAD + ephakathi engundoqo, iphucula ukunganyamezeli kwe-glucose ngokubuyisela amanqanaba e-NAD + kwiigundane ze-HFD-induced T2D.I-NMN iphinda iphucule ubuntununtunu be-insulin ye-hepatic kwaye ibuyisela ukubonakaliswa kofuzo okunxulumene noxinzelelo lwe-oxidative, impendulo yokuvuvukala, kunye nesigqi se-circadian, ngokuyinxenye ngokusebenzisa i-SIRT1 kusebenze.I-NMN isetyenziselwa ukufunda i-motifs ebophelelayo ngaphakathi kwe-RNA aptamers kunye neenkqubo zokuvula i-ribozyme ezibandakanya i-β-nicotinamide mononucleotide (Beta-NMN) -i-RNA fragments.
I-Nicotinamide mononucleotide (“NMN” kunye ne “β-NMN”) yi-nucleotide ephuma kwi-ribose kunye ne-nicotinamide.I-Niacinamide (i-nicotinamide,) luhlobo lwe-vitamin B3 (niacin.) Njenge-precursor ye-biochemical ye-NAD +, inokuba luncedo ekuthinteleni i-pellagra.
Ifom yayo engagxininiswanga, i-niacin, ifumaneka kwimithombo eyahlukeneyo yezondlo: I-Peanuts, ama-Mushrooms (i-portobello, i-grilled), i-Avocados, i-Peas eluhlaza (entsha), kunye neentlanzi ezithile kunye nenyama yezilwanyana.
Kwizifundo [kwiimpuku], i-NMN ibonise ukubuyisela umva ukungasebenzi kakuhle kwemithambo enxulumene neminyaka ngokunciphisa uxinzelelo lwe-oxidative.
Igama: Beta-Nicotinamide Mononucleotide
I-CAS＃: 1094-61-7
Igama lemveliso: Beta-Nicotinamide Mononucleotide;NMN
Elinye igama:β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;Nicotinamide Ribotide;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide
CAS:1094-61-7
Ifomula yemolekyuli: C11H15N2O8P
Ubunzima beMolekyuli: 334.22
Ubunyulu:98%
Ubushushu boGcino: 2-8°C
Imbonakalo: Umgubo omhlophe
Sebenzisa: anti-ukuguga
Umsebenzi:
I-1.Nicotinamide mononucleotide kwiiseli zomntu idlala indima ebalulekileyo ekuveliseni amandla, ibandakanyeka kwi-NAD ye-intracellular (nicotinamide adenine dinucleotide, ukuguqulwa kwamandla eseli ebalulekileyo i-coenzyme) i-synthesis, esetyenziselwa ukulwa nokuguga, ukuwa kweshukela yegazi kunye nezinye iimveliso zempilo.
2. I-Nicotinamide Mononucleotide i-vitamin e-soluble yamanzi, Imveliso i-white crystalline powder, i-odorless okanye iphantse ibe nevumba, ikrakra kwincasa, i-soluble ngokukhululekile emanzini okanye i-ethanol, i-dissolvable kwi-glycerin.
I-3.I-Nicotinamide Mononucleotide kulula ukuyithatha ngomlomo, kwaye inokusasazwa ngokubanzi emzimbeni, i-metabolites engaphezulu okanye i-prototype ikhupha ngokukhawuleza kumchamo.I-Nicotinamide yinxalenye ye-coenzyme I kunye ne-coenzyme II, idlala indima yokuhanjiswa kwe-hydrogen kwi-biological oxidation yokuphefumula ikhonkco, inokukhuthaza iinkqubo ze-biological oxidation kunye ne-metabolism yezicubu, ukugcina izicubu eziqhelekileyo (ingakumbi ulusu, i-digestive tract kunye ne-nervous system) ingqibelelo inendima ebalulekileyo. .
Ukongeza, i-nicotinamide inokuthintela kunye nokunyangwa kwe-heart block, umsebenzi we-sinus node kunye ne-anti-fast experimental arrhythmias, i-nicotinamide inokuphucula kakhulu izinga lentliziyo kunye ne-atrioventricular block ebangelwa yi-verapamil.
