Iasidi yeSialic (SA), eyaziwa ngokwesayensi njenge “N-acetylneuraminic acid,” yicarbohydrates eyenzeka ngokwendalo.Ekuqaleni yayibekwe yodwa kwi-submandibular gland mucin, ngoko ke igama.I-asidi ye-Sialic ngokuqhelekileyo ikhona ngendlela ye-oligosaccharides, i-glycolipids okanye i-glycoproteins.Emzimbeni womntu, ingqondo inowona mxholo uphezulu weasilic acid.Umxholo we-asilic acid kumbandela ompunga ngamaxesha angama-15 kwizitho zangaphakathi ezifana nesibindi kunye nemiphunga.Owona mthombo wokutya weasilic acid lubisi lwebele, olufumaneka kubisi, amaqanda kunye netshizi.
Kwiyeza, i-glycolipids equkethe i-asilic acid ibizwa ngokuba yi-gangliosides, edlala indima ebaluleke kakhulu kwimveliso kunye nophuhliso lwengqondo kunye nenkqubo ye-nervous.Ngelo xesha, izifundo zezilwanyana zibonise ukuba ukunciphisa amanqanaba e-ganglioside kuhambelana nokungondleki kwangaphambili kunye nokunciphisa amandla okufunda, ngelixa ukuxhaswa nge-asilic acid kunokuphucula ukuziphatha kwezilwanyana.Unikezelo olwaneleyo lwe-asilic acid lunokubaluleka ngokukodwa kuphuhliso oluqhelekileyo lomsebenzi wobuchopho kubantwana abanobunzima bokuzalwa obuphantsi.Emva kokuba umntwana ezelwe, iasidi ye-sialic kubisi lwebele ibalulekile ukuqinisekisa ukukhula kwabo okuqhelekileyo.Uphando lubonise ukuba amanqanaba e-asilic acid koomama emva kokubeleka ayehla ngokuhamba kwexesha.Ke ngoko, ukuthathwa ngokuqhubekayo komthamo owaneleyo we-asilic acid ngexesha lokukhulelwa kwaye emva kokukhulelwa kunokunceda ukugcina amanqanaba e-asilic acid emzimbeni.Ngaphezu koko, umxholo we-asilic acid unxulunyaniswa kakhulu nomxholo we-DHA, ebonisa ukuba kunokwenzeka kakhulu ukudibanisa nokwakheka kwengqondo kunye nophuhliso lomsebenzi wobuchopho kwiintsana, zombini ezinokuthi zibe luncedo ekuphuhliseni ubuchopho bokuqala.
Uphononongo lubonise ukuba ixesha legolide lokuphuhliswa kwengqondo yomntu liphakathi kweminyaka emi-2 kunye ne-2 ubudala.Eli nqanaba lixesha elibalulekileyo lohlengahlengiso lwenombolo yeeseli zengqondo, ukunyuka kwevolumu, ukugqibelela kokusebenza, kunye nokwakhiwa kwenethiwekhi ye-neural.Ke ngoko, oomama abalumkileyo baya kunikela ingqalelo ngokwendalo ekuthatheni isixa esaneleyo se-asilic acid ngexesha lokukhulelwa.Emva kokuba umntwana azalwe, ubisi lwebele luyindlela efanelekileyo yokongeza i-asilic acid kumntwana, kuba malunga ne-0.3-1.5 mg ye-asilic acid nge-milliliter yobisi lwebele.Ngapha koko, zonke izilwanyana ezanyisayo, kubandakanywa nabantu, ziyakwazi ukwenza iasilic acid esibindini ngokwazo.Nangona kunjalo, ukukhula kwesibindi kwabantwana abasanda kuzalwa akukavuthwa, kwaye imfuno yokukhula ngokukhawuleza kunye nokuphuhliswa kwengqondo inokunciphisa ukuhlanganiswa kwe-asilic acid, ngakumbi kwiintsana ezingaphambi kwexesha.Ngoko ke, i-asilic acid kubisi lwebele ibalulekile ekuqinisekiseni ukukhula okuqhelekileyo kunye nophuhliso lomntwana.
Abaphandi base-Australia baye bafumanisa ukuba iintsana ezincancisayo zinezinga eliphezulu le-asilic acid kwi-cortex engaphambili kuneentsana ezondliwa ngobisi olungumgubo.Oku kunokukhuthaza ukubunjwa kwe-synapses, kunceda inkumbulo yomntwana ukuba yenze isiseko esizinzileyo, kwaye iqinise ukuphuhliswa kwenkqubo ye-nervous.
| Igama lemveliso | I-N-Acetylneuraminic acid powder |
| Elinye Igama | I-N-Acetylneuraminic acid, i-N-Acetyl-D-neuraminic acid, i-5-Acetamido-3,5-dideoxy-D-glycerol-D-galactonulosonic acid o-Sialic acid I-Galactononulosonic acid I-Lactaminic acid NANA N-Acetylsialic acid |
| Inombolo yeCAS: | 131-48-6 |
| Umxholo | I-98% yi-HPLC |
| Imbonakalo | Umgubo oMhlophe |
| Ifomula yemolekyuli | C11H19NO9 |
| Ubunzima beMolekyuli | 309.27 |
| Ukukwazi ukunyibilika emanzini | 100% enyibilikayo emanzini |
| Umthombo | I-100% yendalo kunye nenkqubo yokuFela |
| Iphakheji eninzi | 25kg/igubu |
Yintoni iasidi yeSialic
Iasidi yeSialicliqela lezinto eziphuma kwi-neuraminic acid (i-N- okanye i-O-substituted derivatives neuraminic acid).Ngokuqhelekileyo ifom ye-oligosaccharides, i-glycolipids okanye i-glycoproteins.
Iasidi yeSialicikwaligama lelona lungu lixhaphakileyo kweli qela – i-N-acetylneuraminic acid (Neu5Ac okanye i-NANA).
Usapho lwe-asilic acid
Kuye kwaziwa malunga namalungu angama-50, zonke izinto eziphuma kwi-9-carbon sugar neuraminic acid ehlawuliswa kakubi.
I-N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic
iasidi (Neu5Gc) kunye ne-deaminoneuraminic acid (KDN) yimonoma yayo engundoqo.
I-N-acetylneuraminic acid lolona hlobo lodwa lweSialic Acid emzimbeni wethu.
Iasidi yeSialic kunye nendlwane yeNtaka
Ngenxa yokuba iasidi yeSialic ityebile kwindlwane yeentaka, ikwabizwa ngokuba yi-bird's nest acid, nto leyo eyisilathisi esibalulekileyo sokuhlelwa kweentaka.
I-Sialic Acid sesona sithako sesondlo kwindlwane yeNtaka, malunga ne-3% -15% ngobunzima.
Kuko konke ukutya okwaziwayo, indlwane yeNtaka iqulethe eyona nto iphezulu yeasidi yeSialid, malunga namaxesha angama-50 aphezulu kunokunye ukutya.
I-1g indlwane yeNtaka ilingana namaqanda angama-40 ukuba sifumana umlinganiselo ofanayo we-Sialic Acid.
Imithombo ye-Sialic Acid yokutya
Ngokuqhelekileyo, izityalo azinayo i-asilic acid.Ubonelelo oluphambili lweSialic acid lubisi lomntu, inyama, iqanda, kunye netshizi.
Iziqulatho zeasidi yeSialic iyonke ekutyeni okuqhelekileyo (µg/g okanye µg/ml).
| Isampulu yokutya okukrwada | Neu5Ac | Neu5Gc | Iyonke | I-Neu5Gc, i-% yetotali |
| Yenkomo | 63.03 | 25.00 | 88.03 | 28.40 |
| Amafutha enyama yenkomo | 178.54 | 85.17 | 263.71 | 32.30 |
| Inyama yehagu | 187.39 | 67.49 | 254.88 | 26.48 |
| inyama yegusha | 172.33 | 97.27 | 269.60 | 36.08 |
| iham | 134.76 | 44.35 | 179.11 | 24.76 |
| Inkukhu | 162.86 | 162.86 | ||
| Idada | 200.63 | 200.63 | ||
| Iqanda elimhlophe | 390.67 | 390.67 | ||
| Umpakathi weqanda | 682.04 | 682.04 | ||
| Islamoni | 104.43 | 104.43 | ||
| Cod | 171.63 | 171.63 | ||
| Ituna | 77.98 | 77.98 | ||
| Ubisi (2% Fat 3% Pr) | 93.75 | 3.51 | 97.26 | 3.61 |
| Ibhotolo | 206.87 | 206.87 | ||
| Itshizi | 231.10 | 17.01 | 248.11 | 6.86 |
| Ubisi lomntu | 602.55 | 602.55 |
Siyabona ukuba iasidi yeSialic kubisi lwabantu iphezulu, eyona nto iphambili ekukhuleni kwengqondo yomntwana.
Kodwa umxholo we-Sialic Acid wahlukile kwiiXesha ezahlukeneyo Ubisi lomntu
Umthubi wobisi lwebele 1300 +/- 322 mg/l
Kwiintsuku ezili-10 kamva 983 +/- 455 mg / l
I-powder yobisi lwentsana yangaphambi kwexesha 197 +/- 31 mg / l
Iifomyula zobisi ezilungelelanisiweyo 190 +/- 31 mg/l
Iifomyula zobisi ezilungelelanisiweyo ngokuyinxenye 100 +/- 33 mg/l
Ukulandelela iifomyula zobisi 100 +/- 33 mg / l
Iifomyula zobisi ezisekelwe kwi-Soy 34 +/- 9 mg / l
Xa kuthelekiswa nobisi lwebele, umgubo wobisi wosana uqulathe malunga ne-20% ye-Sialic acid kubisi lwaBantu, ngelixa usana lunokufumana kuphela i-25% ye-Sialic acid kubisi lwebele.
Kusana olungaphambi kwexesha, iasidi yeSialic ibaluleke ngakumbi kunosana olusempilweni kuphuhliso lwengqondo.
ISialic Acid Study kwiMilk powder
"Iziphumo zibonise ukuba umxholo we-sialic acid yobuchopho udlala indima ebalulekileyo ekumiseleni ukuziphatha.Elinye iqela libone ukuphucula ukufunda ngonyango lwasimahla lweasilic acid kwiimpuku.
Uphononongo lwe-CAB: Iimbono kwezoLimo, iNzululwazi yeMfuyo, iSondlo, kunye neNdalo
Izibonelelo 2006 1, No. 018, Ngaba asilic acid kubisi ukutya ingqondo?, Bing Wang
"Isiphetho siphezulu se-ganglioside yobuchopho kunye ne-glycoprotein sialic acid ekugxilweni kwiintsana ezondliwa ngobisi lomntu kubonisa ukwanda kwe-synaptogenesis kunye nokwahlukana kwe-neurodevelopment."
Am J Clin Nutr 2003;78:1024–9.Ishicilelwe e-USA.© 2003 Umbutho waseMelika weSondlo seClinikhi, i-Brain ganglioside, kunye ne-glycoprotein sialic acid ekuncancisweni xa kuthelekiswa neentsana ezondliwa ngomgubo, uBing Wang
"Iiseli ze-neural membranes zine-asilic acid ephindwe ngama-20 kunezinye iintlobo zeembrane, ezibonisa ukuba i-asilic acid inendima ecacileyo kwisakhiwo se-neural."
I-European Journal of Clinical Nutrition, (2003) 57, 1351-1369, Indima kunye namandla e-asilic acid kwisondlo somntu, uBing Wang
Ukusetyenziswa kwe-N-Acetylneuraminic acid
Umgubo wobisi
Okwangoku, Ubuninzi bobisi lomama abancancisayo, umgubo wobisi wabantwana, kunye nezongezo zeSondlo ziqulethe i-Sialic Acid kwiMarike.
Koomama abancancisayo
Kuba Baby Milk powder 0-12 iinyanga
Kwimveliso yezempilo
YeSiselo
Kuba iasidi yeSialic inesakhono esilungileyo sokunyibilika emanzini, iinkampani ezininzi zizama ukuphuhlisa iziselo ze-Sialic acid kwimpilo yeBrain okanye ukongeza kwiimveliso zobisi.
N-Acetylneuraminic acid Ukhuseleko
I-N-Acetylneuraminic acid ikhuselekile kakhulu.Okwangoku, akukho ndaba zimbi zichazwe kwi-asilic acid.
I-USA, i-China, kunye noorhulumente be-EU bavuma i-asilic acid ukuba isetyenziswe kukutya kunye neemveliso zokhathalelo lwezeMpilo.
i-USA
Ngo-2015, i-N-Acetyl-D-neuraminic acid (i-Sialic acid) yamiselwa Ngokuqhelekileyo iNqondwa njengeKhuselekileyo (GRAS)
eTshayina
Ngo-2017, uRhulumente wase-China wamkele i-N-Acetylneuraminic acid njengeSithako esitsha sokuTya esiNto.
EU
Ukhuseleko lwe-synthetic N-acetyl-d-neuraminic acid njengokutya kwenoveli phantsi koMgaqo (EC) No 258/97
Ngomhla we-16 ngo-Oktobha i-2015, ukutyunjwa kwenkedama (EU / 3 / 12 / 972) yanikezelwa yiKhomishini yaseYurophu kwi-Ultragenyx UK Limited, e-United Kingdom, i-asilic acid (eyaziwa ngokuba yi-aceneuramic acid) yonyango lwe-GNE myopathy.
Uluvo lwezeNzululwazi malunga nokuxhaswa kwamabango ezempilo anxulumene ne-asilic acid kunye nokufunda kunye nememori (ID 1594) ngokungqinelana neSiqendu 13 (1) soMgaqo-nkqubo (EC) No 1924/2006
Umthamo
I-CFDA icebisa i-500mg / ngosuku
Ukutya okunoveli kuphakamisa i-55mg / ngosuku kwiNtsana kunye ne-220mg / ngosuku kubasetyhini abancinci nabaphakathi.
N-acetylneuraminic acid Umsebenzi
Inkumbulo kunye nokuphucula ubukrelekrele
Ngokunxibelelana ne-membrane yeseli yobuchopho kunye ne-synapses, iasidi ye-Sialic yonyusa izinga lokuphendula le-synapses kwiiseli zemithambo-luvo, ngaloo ndlela ikhuthaza uphuhliso lwenkumbulo kunye nobukrelekrele.
Izazinzulu zaseNew Zealand zenze uthotho lwemifuniselo ukuqinisekisa indima ebalulekileyo ye-asidi yentaka ekukhuleni kwengqondo yabantwana.Okokugqibela, abaphandi bagqiba kwelokuba ukongeza kwi-asidi yentaka kwindlwane yeentsana kunokonyusa ukuxinana kwe-asidi yeentaka kwingqondo, ngaloo ndlela kuphuculwe amandla obuchopho okufunda.
Ukuphucula amandla okufunxa amathumbu
Ngokutsho isenzeko elula ngokomzimba yesini esahlukileyo, iiminerali icala kakuhle kunye nezinye iivithamini ezingena emathunjini ngokulula zidityaniswe eyomeleleyo intaka indlwane asidi, ngoko ke ukufunxwa emathunjini iivithamini kunye neeminerali.Isakhono siye sandiswa kuyo.
Ukukhuthaza ukuchithwa kwe-antibacterial intestinal
I-Sialic Acid kwiprotheyini ye-membrane yeseli idlala indima ebalulekileyo ekuphuculeni ukukwazi ukuqondwa kweeseli, ukukhutshwa kwetoksi yekholera, ukuthintela usulelo lwe-Escherichia coli, kunye nokulawulwa kwesiqingatha seprotein yegazi.
Ubomi obude
I-asidi ye-Sialic inempembelelo yokukhusela kunye nokuzinzisa kwiiseli, kwaye ukungabikho kwe-asilic acid kunokukhokelela ekunciphiseni ubomi beeseli zegazi kunye nokuncipha kwe-glycoprotein metabolism.
Phuhlisa iyeza elitsha leSialic Acid
Iingcali zenzululwazi zizama ukunyanga izifo zesisu kunye ne-asilic acid anti-adhesion drug.I-asilic acid anti-adhesive drugs can treat Helicobacter pylori ukunyanga izilonda zesisu kunye nezilonda ze-duodenal.
Iasidi yeSialic yi-glycoprotein.Imisela ukuqaphela okufanayo kunye nokubophelela kweeseli kwaye ineempembelelo ezifanayo zonyango ezifana ne-aspirin.
Iasidi yeSialic lichiza lezifo ezisembindini okanye zemithambo-luvo kunye nezifo ezithomalalisa umzimba;iasilic acid ikwayinto yokukhohlela.
Iasidi yeSialic njengento ekrwada inokuphuhlisa uluhlu lwamachiza eswekile ayimfuneko, i-anti-virus, i-anti-tumor, i-anti-inflammatory, kunye nonyango lwe-senile dementia ineziphumo ezibalaseleyo.
Inkqubo yemveliso yeSialic Acid
Iimathiriyeli zokuqala ekrwada ubukhulu becala yiglucose, utywala obunxilisayo bombona, iglycerinum, kunye nemagnesium sulfate.Kwaye sisebenzisa itekhnoloji ebilisiweyo.Ngexesha lale nkqubo, sisebenzisa indlela yokuvala inzala ukugcina imathiriyeli icocekile.Emva koko nge-hydrolysis, ukugxila, ukomisa, kunye nokubetha.Emva kwazo zonke iinkqubo, sifumana imveliso yokugqibela.Kwaye i-QC yethu iya kusebenzisa i-HPLC ukuvavanya umgangatho wezinto eziphathekayo kwibhetshi nganye ngaphambi kokuba siyihambise kubaxhasi.
Igama leMveliso: Iasidi yeSialic ;N-Acetylneuraminic acid
Elinye Igama:5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactononulosonic acid Lactamineic acid NANA N-Acetylsialic acid
Imvelaphi: Indlwane yeentaka ezityiwayo
Ubalo: 20%–98%
Ukubonakala: umgubo omhlophe omhlophe
INOMBOLO YECAS: 131-48-6
MW: 309.27
MF: C11H19NO9
Indawo yemvelaphi: eTshayina
Ugcino: Gcina kwindawo epholileyo neyomileyo, gcina kude nokukhanya okuthe ngqo kunye nobushushu.
Ukusebenza: Iminyaka emibini ukuba igcinwe ngokufanelekileyo.
UMSEBENZI:
1. Umsebenzi we-Anti-virus.
2. Umsebenzi wokulwa nomhlaza.
3. Umsebenzi wokuchasana nokudumba.
4. Umsebenzi wokukhusela ngokuchasene nosulelo lwe-bacteriologicalg.
5. Ukulawula amandla amajoni omzimba.
6. Ukuthintela ukukwazi ukuchasana ne-pigmentation.
7. Ukuguqulwa komqondiso kwiiseli ze-nerve.
8. Dlala indima ephambili ekukhuleni kwengqondo nasekufundeni.
9. Njengesandulela sokwenziwa kwamachiza amaninzi axuba amayeza.
