Oleoylethanolamide(OEA)

Igama lemveliso:Oleoylethanolamide, N-Oleoylethanolamide, OEA
Elinye igama:N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide , N-(2-Hydroxyethyl)oleamide
Inombolo yeCAS:111-58-0
Ifomula yeemolekyuli:C₂₀H₃₉NO₂
Ubunzima beMolekyuli:325.5
Isivavanyi:90%, 95%, 85% min
Imbonakalo :umgubo onemibala ekhrimu

Oleoylethanolamideyinto entsha kwimarike yezondlo njengesithako esithandwayo sokuncedisa ukutya esisetyenziselwa kwiifomula zokulahlekelwa kwesisindo.Uninzi lwabalandeli bokwakha umzimba baxoxa nge-oleoylethanolamide kwi-reddit kunye namanye amaqonga enethiwekhi yoluntu.

I-Oleoylethanolamide yi-metabolite yendalo ye-oleic acid eyenziwe emathunjini amancinci ngaphakathi komzimba womntu.Yenzeka ngokwemvelo, kwaye iingcali ziyibiza ngokuba "yinto engapheliyo".

I-OEA ngumlawuli wendalo wokutya, ubunzima kunye ne-cholesterol.Yimetabolite yendalo eyenziwa ngamanani amancinci emathunjini akho amancinci.I-OEA inceda ukulawula indlala, ubunzima, amanqatha omzimba kunye ne-cholesterol ngokubophelela kwi-receptor eyaziwa ngokuba yi-PPAR-Alpha (i-Peroxisome proliferator-activated receptor alpha).Ngokwenyani, i-OEA yonyusa imetabolism yamafutha omzimba kwaye ixelele ingqondo yakho ukuba uhluthi kwaye lixesha lokuyeka ukutya.I-OEA yaziwa nangokunyusa inkcitho yekhalori enxulumene nokungazilolongi.

Imbali yeOleylethanolamide

Imisebenzi yebhayoloji ye-Oleoylethanolamide yafunyanwa kwangoko kwiminyaka eyi-50 eyadlulayo.Phambi kuka-2001, bekungekho phando lungako kwi-OEA.Nangona kunjalo, ngaloo nyaka, abaphandi baseSpain baqhekeza i-lipid kwaye bafunda indlela eyenziwe ngayo, apho isetyenziswa khona kunye nento eyenzayo.Bavavanya isiphumo se-OEA kwingqondo (yeempuku) ngokuyitofa ngokuthe ngqo kwiiventricles zobuchopho.Abafumananga siphumo sokutya kwaye baqinisekisa ukuba i-OEA ayenzi engqondweni, kodwa endaweni yoko, ibangela umqondiso owahlukileyo ochaphazela indlala kunye nokuziphatha kokutya.

Oleylethanolamide VS cannabinoid anandamide

Iziphumo ze-OEA zaqala zaphononongwa ngenxa yokuba yabelana ngokufana nenye ikhemikhali, i-cannabinoid eyaziwa ngokuba yi-anandamide.I-Cannabinoids inxulumene nesityalo I-Cannabis, kwaye i-anandamides ekhoyo kwisityalo (kunye nentsangu) inokunyusa umnqweno womntu wokutya i-snack ngokubangela impendulo yokondla.Ngokutsho kweWikipedia, i-Oleoylethanolamide yi-analogue ye-monounsaturated ye-endocannabinoid anandamide.Nangona i-OEA inesakhiwo sekhemikhali esifana ne-anandamide, imiphumo yayo ekutyeni nasekulawuleni ubunzima iyahluka.Ngokungafani ne-anandamide, i-OEA isebenza ngokuzimeleyo kwindlela ye-cannabinoid, ilawula umsebenzi we-PPAR-α ukuvuselela i-lipolysis.

Izakhiwo ze-ethanolamides ezahlukeneyo ze-fatty-acid: i-oleoylethanolamide (OEA), i-palmitoylethanolamide (PEA) kunye ne-anandamide (i-arachidonoylethanolamide, i-AEA).(I-Cima Science Co., Ltd nguyena kuphela umenzi wezinto ezininzi ze-OEA, i-PEA kunye ne-AEA e-China, ukuba ufuna isampuli kunye nexabiso lentengo, nceda usilahle i-imeyile kwiphepha loqhagamshelwano nathi.)

I-OEA ibophelela ngokuhambelana okuphezulu kwi-peroxisome-proliferator-activated receptor-a (PPAR-a), i-nuclear receptor elawula imiba emininzi ye-lipid metabolism.

Imithombo yendalo ye-oleoylethanolamide

I-Oleoylethanolamide yi-metabolite yendalo ye-oleic acid.Ke ngoko, ukutya okune-oleic acid ngumthombo othe ngqo we-OEA.

I-Oleic acid ngawona mafutha aphambili kwi-oyile yemifuno efana nomnquma, i-canola kunye nojongilanga.I-Oleic acid inokufumaneka kwioli ye-nut, inyama, inkukhu, itshizi, njl.

Imithombo yokutya etyebileyo nge-oleic acid ibandakanya: Ioyile yeCanola, iOyile yeOlive, iOyile yeAvocado, iOli yeAlmond, iiavokhado, iOli yeOleic ephezulu eSafflower.

Ezinye iinyani malunga ne-Oleic Acid:

Enye yamafutha axhaphakileyo kubisi lwebele lomntu

Yenza i-25% yamafutha kubisi lwenkomo

I-monounsaturated

I-Omega-9 fatty acid

Ifomula yemichiza yi-C18H34O2(CAS 112-80-1)

Ihlala kunye ne-triglycerides

Isetyenziswa kwizinto zokuthambisa ezinexabiso eliphezulu njengesixhobo sokuthambisa esisebenzayo

Ifumaneka kumafutha obisi, itshizi, ioyile yomnquma, ioyile yegrapeseed, amandongomane, iiavokhado, amaqanda kunye nenyama

Inokuba noxanduva loncedo oluninzi lwezempilo lweoyile yomnquma!

Yenza i-super hero complexes kunye nezinye iiprotheni zobisi ukulwa neeseli zomhlaza

IiNzuzo zeOleoylethanolamide

I-Oleoylethanolamide (OEA) ilungile ukunciphisa umzimba njengomlawuli wokutya kunye nokuxhasa amanqanaba e-cholesterol enempilo kubantu abadala.

I-OEA njengento ecinezela umdla wokutya

Ukucinezelwa kokutya yeyona nto iphambili yokulawula amandla (ukutya) ukutya, ukulawula umdla wokutya kubalulekile ekulawuleni ubunzima bomzimba obunempilo.I-OEA iwulawula njani umdla wakho wokutya?Ungajonga indlela yokusebenza ngezantsi.

I-OEA kunye ne-cholesterol

Ioyile yomnquma yinkanyezi yezondlo, kwaye inceda ukuthoba i-cholesterol "embi" ye-LDL kunye nokwandisa i-HDL "elungileyo".Ngoba?Ukuya kuthi ga kwi-85% yeoli yeoli i-oleic acid, kwaye i-metabolite enempilo ephambili ye-oleic acid yi-OEA (i-Oleoylethanolamide ligama elipheleleyo).Ke ngoko, akukho mathandabuzo okuba i-OEA iyanceda i-cholesterol ephilileyo.

Olunye uphando lubonisa ukuba i-oleoylethanolamide inemiphumo emihle kwixhala, kunye neendlela ezininzi kunye nobungqina obufunekayo ukuxhasa.

Inkqubo yokuvelisa i-Oleoylethanolamide

I-flow char ye-Oleoylethanolamide ingezantsi:

Amanyathelo aBanzi yi: reactiong→inkqubo yokucoca→Hluzo→Iyinyibilikiswe kwakhona kwi-ethanol→ihydrogenation →Hluza uLwelo olucacileyo →icrystallization→Ukuhluza →UkuVavanya→Ukupakisha →Imveliso yokuphelisa

Indlela yokusebenza ye-oleoylethanolamide

Ukuyibeka ngokulula, i-oleoylethanolamide isebenza njengomlawuli wendlala.I-OEA iyakwazi ukulawula ukutya kwakho ngokuxelela ingqondo ukuba umzimba uzele, kwaye akusekho kutya kufunekayo.Utya kancinci yonke imihla, kwaye umzimba wakho usenokungatyebi kakhulu ekuhambeni kwexesha.

Izenzo ezichasene nokutyeba kwe-oleoylethanolamide (OEA) njengoko kuboniswe kumfanekiso.I-OEA idityanisiwe kwaye idityaniswe kumathumbu amancinci asondeleyo ukusuka kwi-oleic acid ephuma kukutya, njengeoyile yomnquma.Ukutya okunamafutha aphezulu kunokuthintela ukuveliswa kwe-OEA emathunjini.I-OEA yehlisa ukuthathwa kokutya ngokuvula i-homeostatic oxytocin kunye ne-histamine yokujikeleza kwengqondo kunye neendlela ze-hedonic dopamine.Kukho ubungqina bokuba i-OEA inokuphinda ithintele i-hedonic cannabinoid receptor 1 (CB1R) ukubonakaliswa, ukusebenza kwayo kuhambelana nokunyuka kokutya.I-OEA inciphisa ukuthuthwa kwe-lipid kwi-adipocytes ukunciphisa ubunzima bamafutha.Ukucaciswa ngakumbi kweziphumo ze-OEA ekuthathweni kokutya kunye ne-lipid metabolism kuya kunceda ekumiselweni kweendlela ze-physiological ezinokujoliswa ekuphuhliseni unyango olusebenzayo ngakumbi lokutyeba.

I-OEA isebenza ukwenza into ebizwa ngokuba yi-PPAR kwaye ngaxeshanye inyusa ukutshiswa kwamafutha kwaye yehlise ukugcinwa kwamafutha.Xa usitya, amanqanaba e-OEA ayanda kwaye umdla wakho uyehla xa imithambo-luvo edibanisa nengqondo yakho ikuxelela ukuba uzele.I-PPAR-α liqela le-ligand-activated nuclear receptor ebandakanyekayo kwi-gene expression of lipid metabolism kunye ne-energyhomeostasis pathways.

I-OEA ibonisa zonke iimpawu ezichazayo ze-satitiety factor:

(1) Ithintela ukondla ngokwandisa ixesha lokutya okulandelayo;

(2) Ukuhlanganiswa kwayo kulawulwa ngokufumaneka kwezondlo kunye

(3) Amanqanaba ayo ahamba ngokuguquguquka kwe-circadian.

Iziphumo ebezingalindelekanga zeOleoylethanolamide

Ukhuseleko lwe-Oleoylethanolamide luyinkxalabo enkulu phakathi kweempawu ezongezelelweyo ezifuna ukuzama le noveli yesithako kwiifomula zabo zokuncipha kobunzima.

Emva kophononongo olubanzi lwalo lonke uncwadi olukhoyo kunye nedatha, i-US Food and Drug Administration (FDA) yayingenaxhala malunga nokhuseleko lwe-OEA.I-RiduZone yinto yokuqala ebizwa ngokuba yi-oleoylethanolamide powder ingredient ukususela kwi-2015.

I-Oleoylethanolamide yi-metabolite ye-oleic acid, eyinxalenye yokutya okunempilo kwansuku zonke.Kukhuselekile ukuzama izongezo ze-OEA, kwaye akukho ziphumo zibi zibikiweyo.

iziphumo zixeliwe.

I-Oleoylethanolamide izilingo zabantu

Kwisifundo esinye, abantu abangamashumi amahlanu (n = 50) abantu abanomdla wokulahlekelwa ubunzima bacetyiswa ukuba bathathe i-OEA 2-3 amaxesha / ngosuku, imizuzu eyi-15-30 ngaphambi kokutya kwiiveki ze-4-12.Izifundo zibandakanya abo bangazange basebenzise iimveliso zokunciphisa umzimba ngaphambili, abo bafumana iziganeko ezingathandekiyo kunye nezinye iimveliso zokunciphisa umzimba, abo balahlekelwa ubunzima kwezinye ii-agent zokunciphisa umzimba ezifana ne-phentermine, abo bazama ukuphumeza utshintsho lwendlela yokuphila (ulawulo lwesahlulo kunye nokuzilolonga rhoqo. ), kunye nabo balawulwa ngokunyanisekileyo kwiimeko zonyango ezibandakanya ukunyamezela kwe-glucose, i-dyslipidemia, uxinzelelo lwegazi kunye nezifo zentliziyo.

Kwisifundo sesibini, izifundo ze-4 ezinezisindo ezisisiseko ze-229, i-242, i-375 kunye ne-193 lbs ngokulandelanayo, ziyalelwe ukuba zithathe ii-capsules ze-Oleoylethanolamide (i-capsule enye equkethe i-200mg 90% OEA).Izifundo zathatha ii-capsules ze-4 (i-1 capsule 15-30 imizuzu ngaphambi kokutya kwaye kwakufuneka bathathe i-capsule eyongezelelweyo ngaphambi kwesidlo sabo esikhulu sosuku) imihla ngemihla ngeentsuku ze-28.Isifundo sokugqibela besikhe sabekwa ngaphambili kwilap band.Izifundo zayalelwa ukuba kungabikho tshintsho kwindlela abatya ngayo kunye nemikhwa yokwenza umthambo.

Iziphumo

Kwisifundo sokuqala, izifundo zilahlekelwe ngumyinge we-1-2 lbs / ngeveki.Kwakungekho ziphumo bezingalindelekanga ngaphandle kwesigulana esinye esifumana isicaphucaphu sexeshana esasonjululwa ngaphantsi kweveki.Kwisifundo sesibini, i-3 kwizifundo ze-4 zichaze ukulahlekelwa kwesisindo (3, 7, 15 kunye ne-0 lbs ngokulandelanayo).Zonke izifundo ze-4 zichaze ukwehla kwe-10-15% kwisayizi yesahlulo, ixesha elide lokutya phakathi kokutya, kwaye akukho miphumo emibi.

Ukuba unomdla kuncwadi oluninzi lwezilingo zabantu nge-OEA, nceda undwendwele amakhonkco ePDF akhutshelwayo.

Idosi ye-Oleoylethanolamide

Kukho ulwazi olulinganiselweyo lophando malunga nokongezwa kwe-OEA yangoku ebantwini, kwaye ngelixa ithathwa njengekhuselekile, akukho dosi icetyiswayo.Nangona kunjalo, kukho ezinye izongezo kwimarike, kwaye unokufumana ezinye zereferensi yakho.

I-dosing ngosuku lwe-RiduZone (i-branded OEA / Oleoylethanolamide 90%) yi-200mg (1capsule ene-OEA kuphela kuyo).Ukuba idityaniswe kunye nezinye izithako zokulahlekelwa kwesisindo, i-dosing yemihla ngemihla ibonakala incinci, yithi i-100mg okanye i-150mg.Ezinye izongezo

Kuyacetyiswa ukuba uthathe izongezelelo ze-oleoylethanolamide imizuzu engama-30 ngaphambi kwesidlo sakusasa kunye nesidlo sangokuhlwa, uya kuziva ugcwele ngakumbi ngexesha lokutya kwaye ngenxa yoko uya kutya kancinci.

Uncwadi lophando kwi-oleoylethanolamide

I-Oleoylethanolamide: Umdlali omtsha kulawulo lwemetabolism yamandla.Indima ekuthathweni kokutya

I-Oleoylethanolamide yonyusa intetho ye-PPAR-Α kwaye inciphisa umdla wokutya kunye nobunzima bomzimba kubantu abatyebe kakhulu: uvavanyo lweklinikhi.

Iimolekyuli zeBrain kunye neSidlo: Ityala le-Oleoylethanolamide

I-Oleylethanolamide ilawula ukondla kunye nobunzima bomzimba ngokusebenza kwe-nuclear receptor PPAR-a

Ukusebenza kwe-TRPV1 yi-Satiety Factor Oleoylethanolamide

Ukulawulwa kokutya kokutya nge-oleoylethanolamide

Indlela ye-oleoylethanolamide kwi-fatty acid efunyenwe emathunjini amancinci emva kokutya kunye nokunciphisa umzimba.

I-Oleoylethanolamide: Indima ye-bioactive lipid amidein modulating indlela yokutya

I-Oleoylethanolamide: Ihlakani elityebileyo kumlo ochasene nokutyeba

I-Oleoylethanolamide: INoveli enokubakho kwi-Pharmacological Alternative kwi-Cannabinoid Antagonists yokulawula ukutya.