Igama Lomkhiqizo:I-CMS121

Elinye Igama:CMS-121;

1,2-Benzenediol,4--[4-(cyclopentyloxy)-2-quinolinyl]-;

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,I-2-diol(CMS121);

ACC,AcetylCoenzymeACarboxylase,isifo,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,ukuwohloka komqondo,ACC1,CMS-121

INOMBOLO YECAS.1353224-53-9

Isivivinyo: 98.0%Miniz

Umbala: Impushana ephuzi ngokukhanyayo

Ukupakisha: 25kg/DRUMS

I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol iyinhlanganisela futhi ebizwa nge-CMS121. Ubunkimbinkimbi besakhiwo sekhompiyutha buphakamisa ukuthi ingaba nezakhiwo ezihlukile kanye nokusetshenziswa okungenzeka. Ukuze uqonde ukubaluleka kwayo, kusiza ukuhlonza amaqembu asebenzayo akhona futhi ahlaziye umthelela wawo ongaba khona

I-CMS121 ifakwe esikhundleni se-quin oline ene-neuroprotective, anti-inflammatory, antioxidative, kanye nemisebenzi yokuvikela kabusha. Igcina amazinga e-glutathione (GSH) kumaseli e-HT22 egundane e-hippocampal ku-vitro lapho kukhona i-glutamate, idala ukuhlukaniswa kwamaseli e-PC12, ivimbele ukusebenza kwe-LPS-induced N9 microglial ngo-82% ku-N9 microglia, futhi isuse ama-radicals mahhala emsebenzini wokuhlushwa olingana ne-Trolox. (TEAC) ukuhlolwa. I-CMS121 ivikela i-ischemia kanye ne-oxytosis ezikrinini ze-phenotypic kumaseli e-HT22 e-vitro anamanani e-EC50 angu-7 no-200 nM ukuze kuvinjelwe ukufa kweseli okubangelwa i-iodoacetic noma i-glutamate, ngokulandelana. Iphinde ivikeleke, inciphise ukuncipha kwesisindo sezinso futhi inciphise ukusho kwe-TNF-α, i-caspase-1, kanye ne-inducible nit ric oxi de synthase (iNOS) kumodeli yegundane ye-SAMP8 yesifo sezinso esingamahlalakhona esihambisana nokuguga ngokushesha lapho kulawulwa umthamo. 10 mg/kg ngosuku kusukela ezinyangeni eziyisishiyagalolunye ubudala.

I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol iyinhlanganisela futhi ebizwa nge-CMS121. Ubunkimbinkimbi besakhiwo sekhompiyutha buphakamisa ukuthi ingaba nezakhiwo ezihlukile kanye nokusetshenziswa okungenzeka. Ukuze uqonde ukubaluleka kwayo, kusiza ukuhlonza amaqembu asebenzayo akhona futhi ahlaziye umthelela wawo ongaba khona. Ukuba khona kweringi ye-quinoline kuphakamisa ukuthi inhlanganisela kungenzeka isebenze ngokwebhayoloji. Ama-molecule atholakala ku-quinoline aziwa ngezakhiwo zawo ezihlukahlukene zebhayoloji, okuhlanganisa imisebenzi elwa namagciwane kanye ne-anti-inflammatory. Okunamathiselwe kweqembu le-cyclopentyloxy kungase kube nomthelela ekuncibilikeni kwenhlanganisela noma kuthuthukise umsebenzi wayo webhayoloji ngemiphumela ebulalayo. Ezifundweni zamaseli e-HT22, i-CMS-121 ibonise imiphumela ebalulekile ye-neuroprotective, ivikela ngempumelelo lawa maseli ekulimaleni kwe-ischemia kanye ne-oxidative. Ngaphezu kwalokho, i-CMS-121 inezici ezibalulekile zokulwa nokuvuvukala, okubonisa amandla ayo okulungisa izimpendulo zokuvuvukala. Ngokwenza kanjalo, i-CMS-121 inamandla okunciphisa ukuvuvukala kwezicubu nezitho ezihlukahlukene. I-CMS-121 inomsebenzi oqinile wezokwelapha njengesivimbeli se-acetyl-CoA carboxylase 1 (ACC1). Umphumela wayo onamandla wokuvimbela ku-ACC1 uwenza inhlanganisela ethembisayo

Isicelo:

I-CMS-121 (CMS121) iyinoveli futhi inamandla okususelwe ku-fisetin ene-anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.I-CMS-121 iphuma ku-quinolone futhi i-acetyl-CoA carboxylase 1 (ACC1) esebenzayo ngomlomo. inhibitor enezinto ezithembisayo zemithi. Ucwaningo olunzulu lwenziwe ukuze kuphenywe izinzuzo ezingaba khona ze-CMS-121 ezindaweni ezihlukahlukene, okuhlanganisa i-neuroprotection, imiphumela elwa nokuvuvukala, umsebenzi we-antioxidant, kanye nomthelela wayo kumakaki ahlobene nokuguga okunempilo.