I-J-147 powder

Isithombe Esifakiwe se-J-147 Powder
  • I-J-147 powder

Incazelo emfushane:

I-J147 i-J-147 iyinhlanganisela enamandla kakhulu, esebenza ngomlomo futhi ebanzi ye-neuroprotective inamandla okuthuthukisa inkumbulo ezilwaneni ezivamile kanye nokuvimbela ukusilela kwenkumbulo ku-Alzheimer's disease (AD) amagundane ashintshashintshayo. Imisebenzi ye-neurotrophic kanye nenkumbulo ye-J-147 ihlotshaniswa nokwanda kwamazinga e-brain derived neurotrophic factor (BDNF) kanye nokuvezwa kwamaprotheni asabelayo e-BDNF, ukuthuthukiswa kwe-LTP, ukulondolozwa kweprotheyini ye-synaptic, ukuncishiswa kwama-amyloid plaque.


  • Intengo ye-FOB:US $0.5 - 2000 / KG
  • Inani elincane le-oda:1 KG
  • Ikhono Lokuhlinzeka:10000 KG/ngenyanga
  • Imbobo:SHANGHAI/BEIJING
  • Imigomo Yokukhokha:L/C,D/A,D/P,T/T
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    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Igama Lomkhiqizo:I-J-147 powder

    Elinye Igama:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147,j147

    Inombolo ye-CAS:1146963-51-0

    Isivivinyo: 99.0%Miniz

    Umbala: Impushana emhlophe

    Ukupakisha: 25kgs Izigubhu

     

    J-147iyi-neuroprotectant enamandla ikakhulukazi ngomlomo etholakala ngokuyinhloko ku-curcumin, isithako esisebenzayo ku-turmeric. Ngokungafani ne-curcumin, idlula umgoqo wegazi-ubuchopho ngempumelelo kakhulu.

    I-J-147 iyi-ejenti enamandla angavamile, esebenza ngomlomo, evikela izinzwa ukuze kuthuthukiswe ingqondo.
    I-J-147 ingadlula kalula isithiyo sobuchopho begazi (BBB). I-J-147 ingavimbela i-monoamine oxidase B (MAO B) kanye nesithuthi se-dopamine esinamavelu e-EC50 ka-1.88 μM no-0.649 μM, ngokulandelana. I-J-147 inamandla okwelapha isifo i-Alzheimer's

    I-J-147 iyi-neuroprotectant enamandla ikakhulukazi esebenza ngomlomo etholakala ngokuyinhloko ku-curcumin, isithako esisebenzayo ku-turmeric. Ngokungafani ne-curcumin, idlula umgoqo wegazi-ubuchopho ngempumelelo kakhulu. Phakathi kwazo, i-J-147 isebenza ngokubophezela ku-ATP synthase. Ukukhiqizwa ngokweqile kwe-ATP kuhlotshaniswa nenqubo yokuguga. Ngaphezu kwamazinga akhulayo ama-neurotransmitters NGF kanye ne-BDNF, i-J-147 ingakwazi ukulawula lokhu. Ngaphezu kwalokho, i-J-147 ivimbela i-monoamine oxidase B kanye ne-dopamine transporter. Ikhuthaza ukukhula kobuchopho ngokwandisa amazinga e-nerve growth factor (NGF) kanye ne-brain-derived neurotrophic factor (BDNF). Okubaluleke kakhulu, i-J-147 ingakhuthaza ukukhula kwamangqamuzana ezinzwa amasha, ithuthukise ikhono lokufunda lobuchopho nenkumbulo, futhi ithuthukise ukusebenza kwengqondo.

    Umsebenzi:

    I-J-147 ingadlula kalula isithiyo sobuchopho begazi (BBB).
    I-J-147 ingavimbela i-monoamine oxidase B (MAO B) kanye nesithuthi se-dopamine esinamavelu e-EC50 ka-1.88 μM no-0.649 μM, ngokulandelana.
    I-J-147 inamandla okwelapha isifo i-Alzheimer's (AD).
    I-J-147 inamandla okwelapha isifo i-Alzheimer's (AD).

    Isicelo:

    I-J-147 iyinhlanganisela yokwenziwa okusebenza kwayo okuyinhloko kuhilela ukuthuthukiswa kwe-mitochondrial, ngaleyo ndlela ithuthukise ukukhiqizwa kwamandla ezingeni lamaselula. I-J-147 yakhelwe ukuthuthukisa ikhono lobuchopho lokuzilungisa nokuzivikela emonakalweni ohlobene neminyaka ngokuthuthukisa ukusebenza kwe-mitochondrial. Ukwengeza, i-J-147 ibonisa izakhiwo ezibalulekile zokulwa nokuvuvukala kanye ne-antioxidant, ithuthukisa nakakhulu imiphumela yayo ye-neuroprotective engaba khona. I-J-147 ingakhuthaza ukukhula kwamangqamuzana ezinzwa amasha, ithuthukise ikhono lokufunda lobuchopho nenkumbulo, futhi ithuthukise ukusebenza kwengqondo.

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