Igama Lomkhiqizo:I-Evodiamine

Elinye Igama:I-Evodiamine, Isoevodiamine, (+)-Evodiamine, d-Evodiamine,I-Fructus Evodiae Extract

Inombolo ye-CAS:518-17-2

Isivivinyo: 98%Miniz

Umbala: I-crystalline powder ephuzi ngokukhanyayo

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-Evodiamine iyi-alkaloid eyingqayizivele ye-bioactive kanye nesithako esiyinhloko se-bioactive emithini yendabuko yamaShayina. Itholakala kumajikijolo esitshalo se-Evodia evodia, esikhula ngokuyinhloko e-China naseKorea.I-Evodiamine iyi-alkaloid eyingqayizivele ye-bioactive kanye nesithako esiyinhloko se-bioactive emithini yendabuko yamaShayina. Itholakala kumajikijolo esitshalo se-Evodia evodia, esikhula kakhulu eChina naseKorea. Lesi sitshalo sicebile ngokwehlukahlukana kwamakhemikhali futhi besilokhu sisetshenziswa emithini yendabuko yamaShayina ukwelapha izinkinga ezahlukahlukene zempilo, ezihlanganisa ukuphazamiseka kokugaya ukudla, ukuvuvukala, nobuhlungu. I-Evodiamine isebenza ngokukhomba izindlela ezihlukahlukene zamangqamuzana emzimbeni. Kuyaziwa ukuthi ivuselela ukusebenza kwama-vanillin receptors, adlala indima ebalulekile ekuboneni ubuhlungu kanye ne-thermogenesis. Ukwengeza, itholwe isebenzisana ne-serotonin kanye ne-dopamine receptors, iphakamisa ukuthi inezici ezithuthukisa isimo sengqondo.

Umsebenzi webhayoloji: I-Evodiamine iyi-alkaloid ehlukanisiwe esithelweni se-Bentham, enemisebenzi ehlukahlukene yebhayoloji efana nokunqanda ukuvuvukala, ukukhuluphala ngokweqile, kanye ne-anti-tumor. I-In vitro: I-Evodiamine ibonise i-cytotoxicity ngokumelene nemigqa yamangqamuzana omdlavuza womuntu ngokudala i-apoptosis. Ngaphezu kwalokho, iyingqamuzana yemvelo eqondiwe kaningi elwa nesimila esebenzisa umsebenzi wokulwa nesimila ngokusebenzisa izindlela ezihlukahlukene zamangqamuzana ezifana nezindlela ezincike ku-caspase nezingancikile, indlela ye-sphingomyelin, i-calcium/JNK signaling, 31 PI3K/Akt/caspase, kanye ne-Fas. -L/. NF – κ B indlela yokusayina 32 [1]. Ku-vivo: I-Evodiamine ivimbela i-metabolism ye-dapoxetine. Uma kuqhathaniswa neqembu lokulawula, i-t1/2, AUC (0- ∞), kanye nemingcele ye-pharmacokinetic ye-Tmax ye-dapoxetine eqenjini le-evodiamine yanda kakhulu ngo-63.3%, 44.8%, no-50.4%, ngokulandelana. Ngaphezu kwalokho, i-evodiamine inciphise kakhulu imingcele ye-pharmacokinetic ye-t1/2 kanye ne-AUC (0- ∞) ye-demethylated dapoxetine [2]. I-Evodiamine ivimbela ukukhula kwesimila kumodeli ye-subcutaneous H22 xenograft. I-Evodiamine inciphisa i-angiogenesis eyenziwe yi-VEGF ku-vivo.

I-In vitro: I-Evodiamine ikhombisa i-cytotoxicity ngokumelene nemigqa ehlukahlukene yamaseli omdlavuza womuntu ngokudala i-apoptosis. Ngaphezu kwalokho, iyingqamuzana yemvelo eqondiwe kaningi elwa nesimila esebenzisa umsebenzi wokulwa nesimila ngokusebenzisa izindlela ezihlukahlukene zamangqamuzana ezifana nezindlela ezincike ku-caspase nezingancikile, indlela ye-sphingomyelin, i-calcium/JNK signaling, 31 PI3K/Akt/caspase, kanye ne-Fas. -L/. NF – κ B indlela yokusayina 32 [1].

Ku-vivo: I-Evodiamine ivimbela i-metabolism ye-dapoxetine. Uma kuqhathaniswa neqembu lokulawula, i-t1/2, AUC (0- ∞), kanye nemingcele ye-pharmacokinetic ye-Tmax ye-dapoxetine eqenjini le-evodiamine yanda kakhulu ngo-63.3%, 44.8%, no-50.4%, ngokulandelana. Ngaphezu kwalokho, i-evodiamine inciphise kakhulu imingcele ye-pharmacokinetic ye-t1/2 kanye ne-AUC (0- ∞) ye-demethylated dapoxetine [2]. I-Evodiamine ivimbela ukukhula kwesimila kumodeli ye-subcutaneous H22 xenograft. I-Evodiamine inciphisa i-angiogenesis eyenziwe yi-VEGF ku-vivo.

UMSEBENZI:

Imisebenzi elwa nokuvuvukala, elwa nesimila, kanye ne-hypoglycemic inemiphumela ethile yokwelapha ekwelapheni ukuwohloka komqondo ongase ube khona kwasekuqaleni kanye ne-stroke. Ine-analgesic, yehlisa umfutho wegazi futhi ibangele ukwenyuka okukhulu kwemiphumela yokushisa komzimba. Umsebenzi womtholampilo walo mkhiqizo ukukhiqiza ama-ejenti wezokwelapha ama-diuretics kanye nomjuluko.

1. I-Evodia extract isetshenziselwa ukwelapha izimpawu zokucindezeleka kwesisu. Lokhu kuhlanganisa isicanucanu, ukuhlanza, nesifo sohudo. Kuthiwa isebenza kakhulu ekwelapheni isifo sohudo sasekuseni.

2. I-Evodia isetshenziselwa ukuvuselela isifiso sokudla kanye nokwelapha izimpawu zesisu ezihambisana nokungabi nesithakazelo ekudleni.

3. I-Evodia extract nayo ine-anti-inflammatory, anti-tumor, anti-viral, astringent, kanye ne-diuretic properties.

4. I-Evodiamine ene-analgesia, ukwehlisa umfutho wegazi nokukhuphuka kwezinga lokushisa lomzimba neminye imiphumela yemithi.

5. I-Evodiamine ine- stomachic, yeka ukuphinda, umphumela we-oxyrygmia kanye nomphumela we-diuretic.

I-6.I-Evodiamine inomphumela oqinile wokuvimbela ku-li; kanye nomphumela obalulekile wokubulala izinambuzane ku-ascarissuum;

7.I-Evodiamine nayo inganciphisa isibeletho futhi inyuse umfutho.

8.Ngaphandle kwalokho, i-evodiamine iphinde ibe nomthelela omuhle esifweni se-Alzheimer kanye nesifo sohlangothi.

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