L-ERGOTHIONEINE 99% NGE-HPLC
I-Premium Antioxidant ye-Nutraceutical & Cosmeceutical Applications
1. Uhlolojikelele lomkhiqizo
L-Ergothioneine(ERT) iyi-amino acid eyenzeka ngokwemvelo isulfure etholakala ekuvutshelweni kwe-microbial, etholakala ikakhulukazi kumakhowe afanaI-Tricholoma matsutakefuthiI-Hericium erinaceus. Umkhiqizo wethu uwukuhlanzeka okuphezulu (≥99% nge-HPLC) i-crystalline powder ene-CAS No. 497-30-3, eqinisekiswe ngokuhlaziywa kwe-chromatographic okuqinile. Ibonisa ukuzinza okukhethekile ekwakhiweni kwe-pH 4.0-6.0, okuyenza ilungele ama-serum e-skincare, ama-lotions, nezithasiselo zomlomo .
Izici Eziyinhloko:
- Ubumsulwa: ≥99% (i-HPLC eqinisekisiwe, i-COA eqondene nenqwaba inikeziwe)
- I-Molecular Formula: C₉H₁₅N₃O₂S | Isisindo samangqamuzana: 229.3 g/mol
- Ukunyibilika: 125 mg/mL emanzini (okusizwa nge-ultrasonic)
- Izitifiketi: Okungeyona i-GMO, I-Allergen-Free, I-Vegan-Friendly
2. Ukulawulwa Kwekhwalithi kanye Nendlela Ye-HPLC
Inqubo yethu yokuhlaziya ihambisana namaphrothokholi abuyekezwe ngontanga :
- Ukulungiselela Isampula: 1 mL isiko eliphakathi nendawo elibiliswe ku-94°C imizuzu eyi-10, livuthwe (1600 rpm/30 min), lifakwe i-centrifuged (10,000×g/5 min), futhi ligcinwe ku-20°C uma kudingeka.
- Isistimu ye-HPLC: I-Dionex Ultimate 3000 enesofthiwe ye-Chromeleon .
- Ikholomu: I-Cortecs UPLC T3 (2.1×150 mm, izinhlayiya ezingu-1.6 μm, 120 Å usayizi wembotshana) .
- Isigaba samaselula: Ukukhishwa kwe-gradient kusuka ku-0.1% ye-formic acid kuya ku-70% acetonitrile/0.1% formic acid, izinga lokugeleza ngu-0.3 mL/min.
- Ukutholwa: Ukumunca kwe-UV ku-254 nm, LOQ 0.15 mmol/L.
Amamethrikhi okuqinisekisa:
- Umugqa: 0.3–10 mmol/L (R² >0.99)
- Ukunemba: ≤6% RSD (intra-/inter-assay)
- Ukubuyisela: ~ 100% ukunemba
3. Izinzuzo Zezempilo Nezicelo
3.1 Ukusetshenziswa Komsoco
- Ukuvikelwa kwe-Mitochondrial: Yehlisa ingcindezi ye-oxidative ngokukhipha ama-hydroxyl radicals (IC₅₀: 2.5 μM) nama-anions e-superoxide.
- Ukusekelwa kwe-Telomere: Ibambezela ukufinyezwa kwe-telomere okuhlobene neminyaka yobudala.
- Isikali: Ucwaningo lwezokwelapha luphakamisa ukuthi i-5-20 mg/ngosuku ikhuphula amazinga e-plasma ERT kakhulu.
Imikhiqizo Enconyiwe:
- Amaphilisi: 100 μg–5 mg ngokuphakela ngakunye (isb., Intsha Ebalulekile Ye-LifeExtension) .
- Ama-Synergistic Blends: Ihlanganisa ne-ferulic acid ukuze kuthuthukiswe i-bioavailability .
3.2 Ukusetshenziswa Kwezimonyo
- I-Anti-Aging: Ivimbela i-tyrosinase (ukunciphisa ngo-40% ekugxiliseni okungu-0.5%) futhi ivikela i-elastin ekonakaleni kwe-UV.
- Imihlahlandlela Yokwakha:
- i-pH: 4.0–6.0 (ukuzinza okuphelele)
- Ukugxila: 0.5–2.0% kumaserum/amaloshini
- Ukuhambisana: Izinzile ngovithamini C, i-hyaluronic acid, nama-peptides.
4. Imininingwane Yezobuchwepheshe
| Ipharamitha | Ukucaciswa | Ireferensi |
|---|---|---|
| Ukubukeka | I-crystalline powder emhlophe | |
| Ubumsulwa (HPLC) | ≥99% | |
| I-Melting Point | 275–280°C (ibola) | |
| Isitoreji | 2–8°C esitsheni esingangeni moya | |
| I-Shelf Life | Izinyanga ezingama-24 |
5. Ukuthobela Ukuphepha Nokulawula
- Idatha Yezokuphepha: LD₅₀ >2000 mg/kg (ngomlomo, amagundane); ayikho imiphumela emibi ekuvivinyweni kwabantu .
- Izitifiketi: I-EU Novel Food Approval (Ergoneine®), FDA GRAS .
- Ukuphatha: Sebenzisa ama-respirators agunyazwe i-NIOSH namagilavu amelana namakhemikhali phakathi nokucubungula kwezimboni .
6. Global Supply & Packaging
- Izinketho zokupakisha: 1 kg, 10 kg, 1000 kg (izikhwama ze-aluminium foil ezine-desiccant) .
- Isikhathi Sokuhola: Izinsuku zebhizinisi ezi-3–5 (ukuthunyelwa komhlaba wonke nge-DHL/FedEx) .
- Izimakethe ezisetshenziswayo: USA, EU, Australia, Japan, Brazil.
7. Amagama Abalulekile
- Amagama angukhiye: “I-L-Ergothioneine 99%HPLC”, “Natural Antioxidant Supplier”, “Ergothioneine for Skincare”.
- Faka i-CAS 497-30-3, izimangalo zokuhlanzeka, nemigomo yesicelo.
