Igama Lomkhiqizo:Inhlanganisela 7P

Elinye Igama:Compound7P;2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide ;2-(N-(2-methoxyphenyl)-4- i-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)i-acetamide

Inombolo ye-CAS:1890208-58-8

Imininingwane: 99.0%

Umbala: Impushana emhlophe enephunga kanye nokunambitha

Isimo se-GMO:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-Compound 7p yaboniswa ukuze ikhuthaze ukukhula kwama-axon e-GAP-43-positive kumodeli yezilwane yokulimala kwe-optic nerve, okuphakamisa ukuthi umsebenzi we-neurite outgrowth we-compound 7p in vitro uhumusha ekukhuthazeni ukuvuselelwa kwe-axon ku-Vivo.

Kumodeli yezilwane yokulimala kwe-optic nerve, i-compound 7p yaboniswa ukuze ikhulise ukukhula kwe-gap-43 ama-axon amahle, okubonisa ukuthi umsebenzi we-in vitro neurite outgrowth we-compound 7p uhumusha ekukhuthazeni ukuvuselelwa kwe-axon ku-vivo. yezindlela evumela ngazo ukuvuselelwa kwe-axon ku-vivo izohlinzeka ngesisekelo esinengqondo semizamo yesikhathi esizayo yokuthuthukisa amasu okwelapha.

I-Compound 7P ibhekisela kunhlanganisela ethile yemvelo equkethe ama-athomu ekhabhoni ayisikhombisa. Kumakhemikhali ezinto eziphilayo, ikhabhoni iyisici esibalulekile ngoba ingakha izibopho ezizinzile namanye ama-athomu, kuhlanganise nama-athomu ekhabhoni, ukuze akhe ama-molecule ayinkimbinkimbi. Lawa ma-molecule angaba nezinhlobonhlobo zezakhiwo nemisebenzi, okwenza izinhlanganisela ezisekelwe kukhabhoni zibe yizakhi zokuphila. Ezilwaneni zezilwane zokulimala kwe-optic nerve, i-compound 7p yaboniswa ukuze ikhulise ukukhula kwe-GAP-43-positive axon, ephakamisa ukuthi umsebenzi wokukhula kwe-neurite we-compound 7p in vitro uhumusha ekukhuthazeni ukuvuselelwa kwe-axonal ku-vivo. I-Compound 7P powder iyimpushana emhlophe ukuya emhlophe ekhiqizwa njengenhlanganisela ye-tandem yokuhlonza i-thromboxane receptor antagonist inhibitors esebenza kabili. Eqinisweni, i-compound 7p ibonise ukukhetha kwe-prostaglandin I2 synthase (PTGIS, CYP8A1) ehlobene ne-thromboxane synthase (CYP5A1). I-nootropic compound 7P powder ikhuthaza ukukhula kwe-Gap-43-positive axon, ngaleyo ndlela ikhuthaze ukuvuselelwa kwe-axonal emzimbeni. I-Complex 7p yekhwalithi ephezulu iklanyelwe ukuthuthukisa ukusebenzisana, ukuthuthukisa isimo sengqondo nokusiza ukulwa nokukhathala. Iphinde ivimbele ukucwiliswa kobuchopho futhi isize ukulwa nokulimala kobuchopho okubangelwa ukuphuza utshwala.

Umsebenzi:

Ukuvuselelwa kwe-axon ngemva kokulimala ohlelweni lwezinzwa olumaphakathi kuyaphazamiseka ngokwengxenye ngoba uma ukwehla okuncike eminyakeni yobudala emandleni okukhula kwe-axon yangaphakathi , futhi elinye lamasu okukhuthaza ukukhula kwe-axon kuma-neurons alimele lihilela ukuxhaphazwa kwemithi yezindlela zokusayina ezithintekayo.lapha siyabika isikrini esisekelwe kuseli se-phenotypic semitapo yolwazi yamakhemikhali kanye nokwenza ngcono okuqondiswayo kwesakhiwo okuholele ekuhlonzeni i-compound 7p e ithuthukisa ukuphuma kwe-neurite yama-neuron athuthukisiwe atholakala ku-hippocampus, i-cerebral cortex, ne-retina. kumodeli yezilwane yokulimala kwe-optic nerve, i-compound 7p yaboniswa ukuze ikhulise ukukhula kwe-gap-43 ama-axon amahle, okubonisa ukuthi umsebenzi we-in vitro neurite wokuphuma kwe-compound 7p uhumusha ekukhuthazeni ukuvuselelwa kwe-axon ku-vivo. yezindlela evumela ngazo ukuvuselelwa kwe-axon ku-vivo izohlinzeka ngesisekelo esinengqondo semizamo yesikhathi esizayo yokuthuthukisa amasu okwelapha.
Isicelo:

Manje sekuyisidakamizwa esihlakaniphile se-nootropic esiziveza kwelinye lama-racetam anamandla endaweni yonke ye-nootropic. Yenziwe kusukela ekilasini lezinhlanganisela ezibizwa ngokuthi i-racetams, futhi isebenza nge-acetylcholine kuphela kodwa futhi nama-receptors e-GABA ebuchosheni, lokhu kunamandla okwenza kokubili i-cholinergic ne-glutamate receptors ye-cerebral cortex, futhi iyisidakamizwa se-racetam esiguquguqukayo ngenxa yobuningi bayo. indlela eyingqayizivele yokwenza. I-Fasoracetam okwamanje iphinde ibonise izinzuzo njenge-anti-depressant, i-ADHD stimulant, kanye ne-anxiolytic, futhi, njengoba kufakazelwa kuma-laboratories esizweni sonke, isiza ekwakhiweni nasekugcinweni kwezinkumbulo ezintsha.