Khoom npe:Syringae Cortex Extract

Lwm Lub Npe: Japanese lilac (syringa reticulata);Syringa reticulata amurensis;Syringa reticulata amurensis;Syringa reticulata (Bl.)Hara var.mandshurica (Maxim.) Hara

Botanic Source: Syringae Cortex Bark

Latin Lub Npe: Syringa reticulata (Blume) Hara var.amurensis (Rupr.) Pringle

Kev ntsuam xyuas:Eleutheroside b, Oleuropein

CAS Nr:118-34-3 ib, 32619-42-4 ib

Xim: daj-xim av hmoov nrog cov yam ntxwv tsw thiab saj

Specification:Eleutheroside b5% + Oleuropein 20%;Eleutherosideb 8% + Oleuropein 35%;Eleutherosideb 10% yog ';Eleutheroside b 98%;

GMO Status: GMO Dawb

Ntim: hauv 25kgs fiber ntau nruas

Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

Lub neej txee: 24 lub hlis txij li hnub tsim khoom

Lub Syringae Folium (SF), sau tseg nyob rau hauv Suav Pharmacopeia, tau siv nyob rau hauv tshuaj ntsuab tshuaj kho mob inflammatory kab mob thiab nws cov dej extract ntawm SF, Yanlixiao (YLX) uas yog coj mus muag npaj tshuaj suav tshuaj tau dav siv nyob rau hauv kev kho mob ntawm cov hnyuv.Txhawm rau tshawb xyuas nws cov khoom siv kho mob hauv SF, ib feem zoo ntawm SF (ESF) tau pom los ntawm bio-guided cais thiab ntxiv dag zog ntawm cov khoom nquag.Hauv qhov kev tshawb fawb no, ESF tau txheeb xyuas tias yog cov tshuaj tiv thaiv kab mob los ntawm kev sib piv cov ciaj sia taus ntawm LPS-induced inflammatory mouse model.Lub hauv vivo tiv thaiv kab mob ua haujlwm ntawm ESF tau sim ntxiv los ntawm tus qauv nas pob ntseg edema.Kaum tsib lub ntsiab ntawm ESF raug cais tawm ntawm ESF tom qab kev txheeb xyuas los ntawm UPLC-TOF-MS, thiab lawv cov inhibition ntawm lipopolysaccharide (LPS)-induced nitric oxide (NO) ntau lawm tau sim nrog rau ESF hauv RAW 264.7 macrophages cell kab.Lub hom phiaj los tshawb nrhiav nws cov txheej txheem tiv thaiv kab mob, kev tshawb fawb tshuaj hauv network tau ua raws li cov khoom tseem ceeb.Raws li cov txiaj ntsig, ESF tau pom tias muaj txiaj ntsig zoo dua hauv kev tiv thaiv pob ntseg o (82.2 mg / kg, 43.7%) piv nrog YLX (293.3 mg / kg, 37.9%).Lub caij no, cov ntsiab lus ESF tseem ceeb, luteolin thiab quercetin tau pom tias muaj txiaj ntsig zoo hauv kev txo qis NO ntau lawm piv nrog aminoguanidine (zoo tswj) (81.3%, 78.7% thiab 76.3%, feem, 50 μg / ml).Kev soj ntsuam ntawm lub network pharmacology kuj tau qhia tias luteolin thiab quercetin tuaj yeem yog cov khoom tseem ceeb rau kev tiv thaiv kab mob ntawm ESF, thiab NFKB1, RELA, AKT1, TNF thiab PIK3CG tau txheeb xyuas raws li lub hom phiaj tseem ceeb thiab MAPK, NF-κB, TCR thiab TLRs signaling. Txoj hauv kev tuaj yeem koom nrog hauv kev tiv thaiv kab mob ntawm ESF.Cov txiaj ntsig tau txais hauv qhov kev tshawb fawb no tau qhia tias ESF muaj peev xwm tsim tau los ua cov tshuaj tiv thaiv kab mob uas siv hauv tsev kho mob.

Syringae Cortex Extract yog cov khoom sib xyaw muab rho tawm los ntawm Syringa reticulata, thiab nws cov khoom xyaw tseem ceeb yog Eleutheroside b thiab Oleuropein.

Eleutheroside yog ib pawg ntawm cov sib txuas sib txawv cais los ntawm cov hauv paus hniav ntawm Acanthopanax senticosus, muag muag feem ntau hauv cov extracts.Eleutheroside B (syringin) yog phenyl propyl glycosides uas tuaj yeem siv los ua Suav tshuaj ntsuab npaj thiab kev noj haus ntawm Eleutherococcus senticosus.

Oleuropein yog glycosylated theem nrab iridoid compound, uas yog ib qho iab phenolic compound uas muaj nyob rau hauv ntsuab txiv ntseej tev, pulp, noob, thiab nplooj.Nws feem ntau pom muaj nyob rau hauv cov txiv ntseej, tab sis kuj tseem muaj ib feem ntawm syringae cortex txog nws lub neej, uas tsis muaj qhov tsis txaus ntseeg muab cov syringae cortex extract nrog cov txiaj ntsig zoo dua.