Aha ngwaahịa:Agomelatine

Aha ndị ọzọ: N-[2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N-[2- (7methoxynaphthalen-1-yl) ethyl] acetamide

CAS Mba:138112-76-2

Nkọwa: 99.0%

Agba: White fine ntụ ntụ nwere njirimara na uto

Ọnọdụ GMO: GMO efu

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Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

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Agomelatinebụ ụdị antidepressant ọhụrụ. Usoro ihe omume ya na-agbaji site na usoro mgbasa ozi monoamine ọdịnala.Agomelatine bụ agonist melatoninergic na onye na-emegide ndị na-anabata 5-HT2C, na egosiri na ọ na-arụ ọrụ n'ọtụtụ ụdị anụmanụ nke ịda mbà n'obi. Agomelatine (S20098) gosipụtara ụkpụrụ pKi nke 6.4 na 6.2 na nwa amaala (porcine) na cloned, mmadụ (h) 5-hydroxytryptamine (5-HT) 2C, n'otu n'otu.

Agomelatine bụ otu ụdị nke na-acha ọcha ma ọ bụ ọcha crystalline ntụ ntụ ma ọ bụ na-acha ọcha siri ike. Aha IUPAC nke kemịkalụ a bụ N-[2- (7-methoxynaphthalen-1-yl) ethyl] acetamide. Kemịkalụ a bụ nke Aromatics Compounds;Aromatics;Neurochemicals;APIS. Ekwesịrị ịchekwa ya na friji -20 Celsius.

 
Dị ka onye na-ahụ maka ọgwụ na-emepụta ọgwụ, a na-eji Agomelatine mee ihe na ọgwụgwọ nke nnukwu nsogbu ịda mbà n'obi, nsogbu mmetụta uche. A na-eji Agomelatine mee ihe na ọgwụgwọ nke nnukwu nsogbu ịda mbà n'obi, nsogbu mmetụta uche. Ihe ọgwụ maka sistemu akwara. Antidepressant, anxiolytic, ịhazigharị ụda nke ụra na ịhazi elekere ndu. Agomelatine bụ agonist melatoninergic na onye na-emegide ndị na-anabata 5-ht2c. Agomelatine bụ ọgwụ antidepressant. A na-ekewa ya dị ka norepinephrine-dopamine disinhibitor (NDDI) n'ihi mmegide ya nke onye na-anabata 5-HT2C. Agomelatine bụkwa onye na-eme ihe ike na ndị na-anabata melatonin nke na-eme ka ọ bụrụ onye mbụ melatonergic antidepressant.

.Agomelatine nwere njikọ chiri anya na melatonin. Agomelatine bụ agonist dị ike na ndị na-anabata melatonin na onye na-emegide ndị na-anabata serotonin-2C (5-HT2C), nwalere n'ụdị anụ ọhịa nke ịda mbà n'obi.

Agomelatine bụ antidepressant eji agwọ ịda mbà n'obi.

Ụbụrụ na-adịkarị mma n'ịhụ na anyị nwere kemịkalụ zuru oke anyị kwesịrị ịrụ ọrụ nke ọma. Ma ịda mbà n'obi nwere ike imetụta ọtụtụ ọgwụ ụbụrụ ụbụrụ.

Chemicals ndị a gụnyere noradrenaline, dopamine na serotonin; ịda mbà n'obi na-ebelata ọkwa nke ụbụrụ ụbụrụ ndị a. Ịda mbà n'obi na-emetụtakwa kemịkalụ a na-akpọ melatonin. Ejikọtara melatonin mbelata na ọgbaghara na usoro ihi ụra anyị.

Agomelatine bụ antidepressant mbụ na-abawanye ọrụ melatonin ozugbo. Ọ na-eme nke a site n'ime ka melatonin na saịtị ndị a na-achọsi ike ebe melatonin na-arụ ọrụ. (A maara ndị a dị ka ndị na-anabata melatonin). Site na ịbawanye ọrụ melatonin, agomelatine na-abawanye ọrụ nke noradrenaline na dopamine ozugbo.

Ebu ụzọ malite Agomelatine na Europe na 2009 ma kwadoro ugbu a maka ojiji na ihe karịrị mba 70. N'adịghị ka antidepressants ọdịnala, agomelatine na-arụ ọrụ site n'ịchụso melatonin na ndị na-anabata serotonin na ụbụrụ. Site n'ime ihe dị ka agonist na ndị na-anabata melatonin, agomelatine na-enyere aka ịhazi usoro ihi ụra na-akpaghasị nke na-ejikọtakarị na ịda mbà n'obi. Usoro a abụghị naanị na-enyere aka melite ogo ihi ụra kamakwa ọ na-enye aka weghachi usoro ụda circadian eke. Na mgbakwunye, agomelatine na-eme dị ka onye na-emegide ya na ụfọdụ ndị na-anabata serotonin (5-HT2C receptors). Omume abụọ a pụrụ iche na-eme ka ọnụnọ nke serotonin dị n'ụbụrụ, onye na-ahụ maka nhazi ọnọdụ. Site n'ịchịkwa ọkwa serotonin, agomelatine nwere ike rụọ ọrụ dị ka ọgwụ mgbochi ịda mbà n'obi dị irè, na-ebelata mgbaàmà dịka mwute, enweghị mmasị, mmetụta nke obi amamikpe ma ọ bụ abaghị uru. Na mgbakwunye, agomelatine nwere ike inye uru ndị ọzọ. Nnyocha na-egosi na ọ nwere ike inye aka melite ọrụ ọgụgụ isi Nnyocha na-egosipụta ikike ya ịkwalite ebe nchekwa, nlebara anya, na ọrụ ndị isi, na-eme ka ọ bụrụ ebe na-akpali akpali maka nchọpụta n'ọdịnihu.

Ọrụ:

Agomelatine nwere ike inye aka ịhazi elekere ahụ gị (circadian rhythm) nwere uru dị mma na ọnọdụ na ịda mbà n'obi na-ehi ụra Aomelatine na-eji ọgwụgwọ ịda mbà n'obi ma ọ bụ nyere aka gbochie ịda mbà n'obi ịlaghachi, ma dị naanị na ndenye ọgwụ. Ihe mgbaàmà nke ịda mbà n'obi na-adịgasị iche site n'otu onye gaa na nke ọzọ, ma na-agụnyekarị mwute na-adịgide adịgide, enweghị mmasị n'ihe omume kacha amasị gị, mmetụta nke abaghị uru, nsogbu ihi ụra, mmetụta nke ịda mbà n'obi, mmetụta nke nchekasị ma ọ bụ mgbanwe nke agụụ na ibu ibu. Mgbanwe na ụra gị kwa ụbọchị na usoro agụụ gị bụ ihe atụ nke ọgba aghara nke elekere ahụ gị nke na-enwekarị nkụda mmụọ.