Neohesperidin Dihydrochalcone (NHDC)

NHDC mu mawonekedwe oyera amapezeka ngati chinthu choyera osati mosiyanaufa shuga.

Pawiri pafupifupi 1500-1800 nthawi okoma kuposa shuga m'malo okhazikika;pafupifupi 340 kutsekemera kuposa kulemera kwa shuga.Mphamvu zake zimakhudzidwa mwachilengedwe ndi zinthu monga momwe zimagwiritsidwira ntchito, ndipHza mankhwala.

Monga ena okoma kwambiriglycosides, mongaglycyrrhizinndi omwe adapezeka mustevia, kukoma kokoma kwa NHDC kumayamba pang'onopang'ono kusiyana ndi shuga ndipo kumakhala mkamwa kwa nthawi ndithu.

Mosiyanaaspartame, NHDC ndi yokhazikika ku kutentha kwapamwamba komanso ku acidic kapena zofunikira, ndipo ingagwiritsidwe ntchito pazinthu zomwe zimafuna moyo wautali wautali.NHDC payokha imatha kukhalabe ndi chakudya mpaka zaka zisanu ikasungidwa m'malo abwino.

Chogulitsacho chimadziwika bwino chifukwa chokhala ndi mphamvu ya synergistic chikagwiritsidwa ntchito limodzi ndi zinazotsekemera zopangiramongaaspartame, saccharin, acesulfame potaziyamu,ndicyclamate, komanso zakumwa za shuga mongaxylitol.Kugwiritsa ntchito kwa NHDC kumawonjezera zotsatira za zotsekemera izi m'malo otsika kuposa momwe zikadafunikira;zotsekemera zina zocheperako zimafunikira.Izi zimapereka phindu la mtengo.

Kodi Neohesperidin dihydrochalcone ndi chiyani?

Neohesperidin dihydrochalcone powder, yomwe imadziwikanso kuti Neohesperidin DC, Neo-DHC ndi NHDC mwachidule, ndi chotsekemera chowonjezera chopangidwa ndi neohesperidin.NHDC imatengedwa ngati chotsekemera champhamvu kwambiri, chosapatsa thanzi komanso kukoma kokoma;imatha kusintha kukoma ndi mtundu wa maphikidwe osiyanasiyana a chakudya.

Neohesperidin dihydrochalcone ndi pawiri yomwe imakhala yokoma pafupifupi 1500-1800 kuposa shuga pamlingo wapafupi ndipo imalemera pafupifupi 340 kutsekemera kuposa shuga.

Neohesperidin dihydrochalcone nthawi zambiri amagwiritsidwa ntchito m'mafakitale owonjezera zakudya komanso zakudya zowonjezera.

Dziwani ndi gwero la Neohesperidin dihydrochalcone

Neohesperidin dihydrochalcone inapezeka m'zaka za m'ma 1960 ngati gawo la dipatimenti yofufuza zaulimi ku US kuti apeze njira zochepetsera kuwawa kwa madzi a citrus.Neohesperidin ndi gawo lowawa lomwe limapezeka mu peel ndi zamkati za lalanje wowawa ndi zipatso zina za citrus;imakhalanso ndi flavonoid yogwira ntchito ya citrus aurantium zipatso.Mukathandizidwa ndi potassium hydroxide kapena maziko ena amphamvu, ndiyeno hydrogenated, imakhala Neohesperidin dihydrochalcone (NHDC).

NHDC sichichitika mwachilengedwe.

Neo-DHC ndi hydrogenated kuchokera ku neohesperidin yachilengedwe-chitsime chachilengedwe, koma idasintha kusintha kwamankhwala, kotero sizinthu zachilengedwe.

Neohesperidin dihydrochalcone VS zotsekemera zina

Kukoma kosiyana ndi kukoma

Poyerekeza ndi sucrose, neohesperidin DC imakhala yokoma pafupifupi 1500-1800 kuposa shuga ndipo imakhala yokoma nthawi 1,000 kuposa sucrose, pomwe sucralose imakhala nthawi 400-800 ndipo ace-k imakhala yokoma nthawi 200 kuposa shuga.

Neohesperidin DC imakonda mwaukhondo komanso imakhala ndi zokonda zazitali.Mofanana ndi ma glycosides ena a shuga, monga glycyrrhizin omwe amapezeka mu stevia ndi omwe amachokera ku muzu wa licorice, NHDC yotsekemera imachedwa pang'onopang'ono kusiyana ndi shuga ndipo imakhala mkamwa kwa nthawi yaitali.

Kukhazikika kwabwino komanso chitetezo chokwanira

NHDC ndi yokhazikika pansi pa kutentha kwambiri, acidic kapena alkaline mikhalidwe chifukwa chake ingagwiritsidwe ntchito pazinthu zomwe zimafuna moyo wautali wa alumali.NHDC imatha kusunga chakudya mpaka zaka zisanu pamikhalidwe yabwino

Ma receptor osiyanasiyana

Lingaliro laumunthu la kukoma ndi kukoma kumayanjanitsidwa ndi T1Rs, banja loyamba la GPCRs, TIRs amawonetsedwa mwachisangalalo cha mkamwa lofewa ndi lilime, kuphatikizapo TIR1, T1R2, ndi TIR3, zomwe nthawi zambiri zimapezeka mu mawonekedwe a dimers.Dimer T1R1-TIR3 ndi cholandirira cha amino acid, chomwe chimawonetsa komanso kutenga nawo gawo pakuzindikira kukoma.Dimer T1R2-T1R3 ndi cholandirira chokoma, chomwe chimatenga nawo gawo pakuzindikira kukoma kokoma.

Zotsekemera monga sucrose, aspartame, saccharin, ndi cyclamate zimagwira ntchito kudera la extracellular la T1R2.NHDC ndi cyclamate amachita pa gawo la transmembrane la T1R3 kuti apange kukoma.Neohesperidin DC imalumikizana ndi zotsalira za amino acid m'chigawo cha transmembrane cha T1R3 kuti ipangitse kukoma kwake ndipo nthawi yomweyo, imatha kuyambitsa kutsekemera kwa dimer T1R2-T1R3.Monga chotsekemera, NHDC imakhala ndi zotsatira zotsekemera kwambiri zikaphatikizidwa ndi zotsekemera zina zokhala ndi zosakaniza zochepa.

Kupatula apo, Neohesperidin DC imasiyana ndi zotsekemera zachikhalidwe m'ntchito zake zotsekemera, kuwonjezera fungo, kubisa zowawa, ndikusintha kukoma.

Ubwino ndi kugwiritsa ntchito neohesperidin dihydrochalcone (NHDC)

Antioxidant Properties

M'zaka zaposachedwa, kafukufuku wambiri akuwonetsa kuti neohesperidin dihydrochalcone ili ndi ntchito yayikulu yodalira kusakatula kwa ma free radicals okhazikika komanso mitundu yotakata ya okosijeni (ROS).Makamaka, NHDC ili ndi mphamvu yoletsa kwambiri pa H2O2 ndi HOCl.(kuchuluka kwa HOCl ndi H2O2 kunali 93.5% ndi 73.5% motsatana)

Kuphatikiza apo, NHDC imatha kuletsa kuwonongeka kwa mapuloteni ndi kung'ambika kwa plasmid DNA strand, ndikuteteza HIT-T15, HUVEC cell kufa ku HOCl.

NHDC ili ndi zochita zosiyanasiyana za antioxidant motsutsana ndi ma free radicals osiyanasiyana.Mphamvu ya antioxidant ya NHDC imaphatikizaponso kuti imatha kuletsa pang'ono kuwonongeka kwa pigment komwe kumachitika chifukwa cha polyphenol oxidase, yomwe imatha kuletsanso kuwongolera kwa matrix metalloproteinase (MMP-1) yoyambitsidwa ndi ma radiation ya infrared, motero kuteteza khungu la munthu ku ngozi. kukalamba msanga chifukwa chokhudzidwa ndi cheza cha infrared.

Ntchito: NHDC ikhoza kukhala chowonjezera chotsutsana ndi bulauni komanso choyera

Kutsika kwa shuga m'magazi ndi Kutsika kwa Cholesterol

NHDC ndi chotsekemera chogwira mtima, chosakhala ndi poizoni, chokhala ndi ma calorie ochepa chomwe chimakwaniritsa zosowa za anthu zotsekemera ndipo motero zimachepetsa kudya kwa shuga.

Kafukufuku waposachedwapa wasonyeza kuti NHDC akhoza kuletsa α-amylase mu zoyamwitsa mu madigiri osiyanasiyana ndiyeno kuchepetsa thupi mayamwidwe shuga, potero kuchepetsa magazi shuga m`thupi, amene ndi wofunika kwambiri mankhwala, makamaka odwala matenda a shuga.

Kugwiritsa ntchito: NHDC itha kugwiritsidwa ntchito ngati chotsekemera chopanda shuga, chopanda calorie.Akagwiritsidwa ntchito moyenera, amatha kulowa m'malo mwa sucrose ndikuchepetsa kudya kwa anthu.Ndizoyenera kwa anthu onenepa komanso osanenepa.

Tetezani chiwindi

Zhang Shuo et al.anapeza kuti NHDC ikhoza kuchepetsa milingo ya ALT, AST mu seramu ndi hydroxyproline m'matenda a chiwindi a mbewa omwe ali ndi chiwindi cha CCI, komanso amachepetsa kuchepa kwa maselo ndi necrosis ya maselo ndi chiwindi fibrosis mu madigiri osiyanasiyana.Kuphatikiza apo, kuchepa kwa ALT ndi AST mu seramu kumathandizira kagayidwe ka lipid ndi chiwindi, ndikulepheretsa mapangidwe a chiwindi chamafuta ndi endothelial plaque m'mitsempha yayikulu.

Kupatula apo, NHDC imatha kuchepetsa kuwonongeka kwa okosijeni komwe kumabwera chifukwa cha CC1, kuchepetsa kutupa, ndi apoptosis yama cell.

Ntchito: NHDC ikuyembekeza kugwiritsidwa ntchito ngati hepatoprotective agent.

Pewani zilonda zam'mimba

NHDC imatha kuletsa katulutsidwe ka asidi m'mimba, kotero imatha kugwiritsidwa ntchito ngati antiacid kusakaniza ndi Aluminiyamu Hydroxide Gel kapena othandizira ena omwe amapanga asidi kuti apititse patsogolo kukana kwapamimba kwa asidi.

Suhrez et al.adapeza kuti NHDC ikhoza kuchepetsa kwambiri index ya zilonda zomwe zimayambitsidwa ndi kupsinjika kwa kuzizira (CRS).Ntchito yake ndi yofanana ndi ya ranitidine, yomwe ingalepheretse ntchito ya histamine ndi kuchepetsa kwambiri katulutsidwe ka chapamimba acid ndi pepsin.

Kugwiritsa ntchito: NHDC ikhoza kukhala chinthu chatsopano chamankhwala am'mimba.

Kuwongolera chitetezo chokwanira

NHDC imawonjezeredwa kuti idye monga zotsekemera, osati chifukwa cha kukoma kwake kokoma komanso kuchititsa chilakolako cha nyama, komanso chifukwa cha zotsatira zake za probiotic zopezeka ndi Daly et al.Pamene NHDC idawonjezeredwa ku chakudya cha nkhumba, Lactobacillus mu khomo la caecum la nkhumba inakula kwambiri ndi kuwonjezeka kwa lactic acid ndende m'matumbo.Ikhoza kukhudza zomera za m'mimba za symbiotic, kuchepetsa chitetezo cha mthupi, ndi kuchepetsa matenda a m'mimba.

Ntchito: Neohesperidin DC angagwiritsidwe ntchito ngati chowonjezera chakudya, NHDC bwino palatability wa kudyetsa zinthu, kumawonjezera nyama chilakolako, ndi kusintha mabakiteriya m`mimba, ndiye kumapangitsa kukula kwawo.

Neohesperidin DC chitetezo

NHDC ndi chotsekemera chopanda carrier, chosawotchera.Kafukufuku wapoizoni yemwe wachitika.Kagayidwe ka NHDC m'thupi la munthu ndi chimodzimodzi ndi flavonoid glycosides ena.NHDC ili ndi metabolism yachangu, palibe kukondoweza kwa thupi la munthu, komanso palibe zoyipa zoyipa.

Neo-DHC idasungidwa mu European Pharmacopoeia zaka makumi awiri zapitazo ndikuvomerezedwa ngati chotsekemera ndi European Union, koma osati ndi FDA.Ku United States, neo-DHC imavomerezedwa kuti igwiritsidwe ntchito ngati chowonjezera kukoma.Kupatula apo, kulembetsa kwa NHDC paudindo wa GRAS mu FDA kuli mkati.

Neohesperidin dihydrochalcone (NHDC) analimbikitsa mlingo ndi Zotsatira zake.

Pazakudya zamkaka ndi mkaka, mlingo: 10-35 ppm (zotsekemera), 1-5 ppm (zowonjezera kukoma)

Kwa Kupaka Kuwawa Kwambiri Kwamankhwala, mlingo: 10-30 ppm(zotsekemera), 1-5 ppm (zowonjezera kukoma)

Pazakudya zokometsera, mlingo wokwanira wovomerezeka: 30-35 mg NHDC/kg chakudya chonse, 5 mg NHDC/L madzi;3-8 mg NHDC/L madzi oyamwa ndi kuyamwa

Zolinga zosiyanasiyana zimatsimikizira mlingo.

Komabe, ngati atengedwa mopitirira muyeso, chinthu chilichonse chikhoza kukhala pachiwopsezo ku thupi la munthu.Kafukufuku wasonyeza kuti neohesperidin dihydrochalcone (NHDC) ingayambitse nseru ndi migraine pamene ndende ili pafupi 20 ppm kapena kuposa.Ndikofunikira kuvala masks opangira opaleshoni pochita ndi NHDC yoyera

Satifiketi Yowunikira