Dzina la malonda:Nicotinamide riboside chloride ufa
Dzina lina:3-(Aminocarbonyl) -1-PD-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, vitamini NR; Niagen, TRU NIAGEN
CASNO:23111-00-4
Mapangidwe a maselo: C11H15N2O5.Cl
Kulemera kwa maselo: 90.70 g / mol
Chiyero: 98%
Malo osungunuka: 115 ℃-125 ℃
Maonekedwe:Kuchokera ku White mpaka Ufa Wachikasu Wotuwa
Ntchito: Imakulitsa milingo ya NAD +, Imathandizira Ukalamba Wathanzi komanso ubongo / kuzindikira
Ntchito: monga chowonjezera pazakudya, zakudya zogwira ntchito, ndi zakumwa
Mlingo wovomerezeka: osapitilira 180 mg / tsiku
Nicotinamide riboside ndi mtundu watsopano woyamikiridwa wa Vitamini B3, wokhala ndi mawonekedwe apadera;ndi kalambulabwalo wa NAD +.
Nicotinamide riboside (NR), yomwe idafotokozedwa koyamba mu 1944 ngati chinthu chokulirapo (Factor V) cha fuluwenza ya Haemophilus, ndipo mu 1951, NR, idayamba kufufuzidwa ngati tsogolo la metabolic m'matumbo a mammalian.
Monga momwe mungazindikire, pali mitundu iwiri ya NR yomwe ilipo, imodzi ndi Nicotinamide Riboside, ndipo ina ndi Nicotinamide Riboside chloride.
Kulankhula kwamankhwala, ndi mitundu iwiri yosiyana kwambiri popeza ali ndi manambala osiyanasiyana a CAS, NR yokhala ndi 1341-23-7 pomwe NR chloride yokhala ndi 23111-00-4.NR sikhazikika kutentha kwa chipinda, pamene NR chloride imakhala yokhazikika.Dzina lodziwika bwino lodziwika bwino lotchedwa NIAGEN®, lotulutsidwa ndi Chromadex Inc mu 2013, ndi mtundu wa Nicotinamide riboside chloride, womwe umafuna kusintha zizindikiro za ukalamba mkati mwa thupi lanu.Nicotinamide Riboside yopangidwa kuchokera ku Cima Science ilinso mu mawonekedwe a ufa wa chloride.Ngati sichinatchulidwe, NR idzalozera ku fomu ya NR chloride yomwe ili m'munsimu.
Zakudya za Nicotinamide riboside
Kuchuluka kwa NR muzakudya ndi mphindi, poyerekeza ndi zomwe zili muzakudya zowonjezera.Komabe, ndi zakudya ziti zomwe zimakhala ndi nicotinamide riboside (NR)?
Mkaka wa ng'ombe
Mkaka wa ng'ombe nthawi zambiri umakhala ndi ~ 12 μmol NAD (+) mavitamini / L, omwe 60% analipo ngati nicotinamide, ndipo 40% anali apano ngati NR.(Mkaka wamba unali ndi NR zambiri kuposa mkaka wachilengedwe), kafukufuku wofalitsidwa ndi University of Iowa, mu 2016
Yisiti
Kafukufuku wakale wati, "Chinthu chimodzi choletsa yisiti chidapatulidwa ndi yisiti ndipo chidapezeka kuti ndi nicotinamide riboside, chikhoza kukhala chochokera ku NAD (P) panthawi yokonza zotulutsa yisiti, kapena kuchokera ku zakudya zowonjezera yisiti panthawi yogaya mu vivo."Ngakhale palibe kachulukidwe deta pa yisiti
Mowa
Mowawo uli ndi kuchuluka kwa ma carbs ndipo kumwa omwe ali amadzimadzi ngati amenewo kumakhala ndi zotsatira za glycemic;Mapepala osiyanasiyana ofufuza anena kuti mowa ndi gwero lazakudya la nicotinamide riboside.
Komanso, pakhoza kukhala kuchuluka kwa NR monga mapuloteni a whey, bowa, ndi zina.
Kwa anthu ambiri, mkaka ndi woletsedwa pazifukwa zina.Zakudya za nicotinamide riboside zitha kukhala zothandiza, koma sizothandiza kwambiri kuposa zowonjezera za NR.
Chifukwa chiyani Nicotinamide Riboside (NR) imadziwika ngati NAD + yoyambira ma invertebrates a vitamini?
Pali malingaliro asanu omwe amathandizira izi:
Haemophilus influenza, bakiteriya woyambitsa chimfine, yemwe alibe njira ya de novo ndipo sangathe kugwiritsa ntchito Na kapena Nam, amadalira kwambiri NR, NMN, kapena NAD+ kuti akule m'magazi omwe ali nawo.
Mkaka ndi gwero la NR.
NR imateteza murine DRG neurons mu ex vivo axonopathy assay kudzera transcriptional induction ya nicotinamide riboside kinase (NRK) 2 jini.
Kuwonjezedwa modabwitsa kwa NR ndi zotumphukira kumawonjezera kudzikundikira kwa NAD + motengera mlingo m'mizere ya maselo aumunthu.
Candida glabrata, bowa wotengera mwayi womwe umadalira mavitamini a NAD + kuti akule, amagwiritsa ntchito NR panthawi yofalitsa matenda.
Nicotinamide Riboside VS Nicotinamide VS Niacin
Niacin (kapena nicotinic acid), ndi organic pawiri ndi mtundu wa vitamini B3, zofunika thupi munthu.Ili ndi formula C6H5NO2.
Nicotinamide kapena wotchedwa niacinamide ndi mtundu wa vitamini B3 womwe umapezeka muzakudya ndipo umagwiritsidwa ntchito ngati chowonjezera chazakudya komanso mankhwala.Ili ndi njira C6H6N2O.
Nicotinamide riboside ndi mtundu wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati kalambulabwalo wa nicotinamide adenine dinucleotide kapena NAD+.Ili ndi fomula C11H15N2O5+.
Nicotinamide Riboside Ubwino Waumoyo
Nicotinamide Riboside imathandizira kupanga mphamvu
Mu nyama, NR supplementation inachepetsa kugwiritsa ntchito NAD, zomwe zinapangitsa kuti mitochondrial igwire bwino, kubwezeretsedwa kwa minofu mofulumira, ndi kusunga mphamvu za NAD ndi kuchita masewera olimbitsa thupi mu mbewa zakale, kuthandizira kusunga minofu ndi ntchito, kumathandizira mphamvu zowonjezera mphamvu.
Nicotinamide Riboside imathandizira kuzindikira ntchito
NR imateteza maselo a mitsempha mu ubongo mwa kuyambitsa SIRT3, Supplementation imayambitsa njira za NAD ndikuthandizira kupewa kuwonongeka m'maganizo.
NR imathandizira kuzindikira ndikuchepetsa kukula kwa matenda a Alzheimer's mu mbewa zopatsidwa NR kwa miyezi itatu.
Nicotinamide Riboside imalepheretsa kumva kumva
Poyambitsa njira ya SIRT3, kafukufuku wa UNC adapeza kuti idathandizira kuteteza makoswe kuti asamve chifukwa chaphokoso.
Nicotinamide Riboside amateteza chiwindi
Kutengedwa NR pamlomo kumawonjezera NAD m'thupi, zomwe zimathandiza kuteteza chiwindi.NR inasiya kudziunjikira mafuta, idachepetsa kupsinjika kwa okosijeni, kuteteza kutupa, komanso kukulitsa chidwi cha insulin m'chiwindi cha mbewa.
Kuphatikiza apo, NR imatha kukulitsa moyo wautali, Kuchulukitsa kagayidwe, kuthandizira kulimbana ndi khansa, kuchepetsa zizindikiro za matenda a shuga, kumawonjezera kagayidwe, kungathandize kuchepetsa thupi.
Kodi Nicotinamide Riboside Ndi Yotetezeka?
Inde, NR ndi yotetezeka.
NR ili ndi mayesero atatu azachipatala omwe adasindikizidwa omwe amatsimikizira kuti ndizotetezeka kuti anthu azidya.
Kusanthula mosamala ndikugogomezera zidziwitso zonse zakuchipatala komanso zamankhwala zomwe zilipo pa NR zitsimikizireni kuti ndizotetezeka komanso zololedwa.
Niagen ndiyotetezeka komanso GRAS, pogwiritsa ntchito njira zasayansi, pansi pa Federal Food, Drug, and Cosmetic Act (FFDCA).
Mayesero a Anthu a Nicotinamide Riboside
Pali maphunziro ambiri azachipatala omwe achitika poyesa NR m'machitidwe osiyanasiyana.
Mu 2015, maphunziro oyamba azachipatala a anthu adamaliza, ndipo zotsatira zake zidawonetsa kuti NR mosamala komanso moyenera imakulitsa milingo ya NAD mwa anthu odzipereka athanzi.
Kuyesa kwachipatala koyendetsedwa ndi placebo kwa nicotinamide riboside mwa amuna onenepa mwachisawawa: chitetezo, insulin-sensitivity, ndi lipid-mobilizing zotsatira.
-Lofalitsidwa mu The American/Journal of Clinical Nutrition
Results: 12 wk ya NR supplementation mu mlingo wa 2000 mg / d ikuwoneka ngati yotetezeka, koma sichimapangitsa kuti insulini ikhale ndi mphamvu komanso thupi lonse la shuga m'thupi mwa amuna olemera kwambiri, osamva insulini.
Nicotinamide riboside supplementation imalekerera bwino ndipo imakweza NAD + mwazaka zapakati komanso achikulire athanzi.
-Lofalitsidwa mu Nature Communications
Nicotinamide Riboside Ndi Makamaka komanso Pakamwa Bioavailable mu Mbewa ndi Anthu
-Lofalitsidwa mu Nature Communications
Apa tikufotokozera nthawi ndi zotsatira zotengera mlingo wa NR pamagazi a NAD metabolism mwa anthu.Lipotilo likuwonetsa kuti magazi amunthu NAD amatha kukwera mochuluka ngati 2.7-fold ndi mlingo umodzi wapakamwa wa NR mu kafukufuku woyendetsa munthu m'modzi ndikuti oral NR imakweza mbewa hepatic NAD ndi mankhwala owoneka bwino komanso apamwamba.
