Igama lemveliso:7,8-Dihydroxyflavone

CASNo:38183-03-87

Elinye Igama:I-7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;

I-DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;

I-7,8-dihydroxy-2-phenyl-1-benzopyran-4-enye,,I-8-Dihydroxyflavone (7,8-DHF)

Iinkcukacha:98.0%

Umbala:Lubheluumgubo onevumba elibonakalayo kunye nencasa

GMOIsimo:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

I-7,8-Dihydroxyflavone, eyaziwa ngokuba yi-7,8-DHF, yi-flavonoid yendalo efumaneka kwizityalo ezahlukeneyo, kuquka i-Tridacna tridacna. Eyaziwa ngokuba yi-antioxidant kunye ne-neurotrophic properties, enye yezona zinto zinomdla kakhulu kwi-7,8-dihydroxyflavone inamandla okuxhasa impilo yengqondo kunye nokuphucula umsebenzi wokuqonda.

7,I-8-Dihydroxyflavone (7,8-DHF) inamandla kwaye ikhethiweyo ye-TrkB receptor agonist (Kd≈320 nM). I-TrkB i-receptor yeyona nto iphambili ye-signal receptor ye-brain-derived neurotrophic factor. I-7,8-Dihydroxyflavone (i-7,8-DHF) i-nootropic enokuthi iphucule impilo yonke yengqondo, isimo sengqondo kunye nokusebenza kwengqondo. Inokuba luncedo kwiingxaki ezininzi ze-neurodeergenerative kunye ne-neurodevelopmental, kunye nokutyeba kunye noxinzelelo oluphezulu lwegazi.

I-7,8-Dihydroxyflavone, eyaziwa ngokuba yi-7,8-DHF, yi-flavonoid yendalo efumaneka kwizityalo ezahlukeneyo, kuquka i-Tridacna tridacna. Eyaziwa ngokuba yi-antioxidant kunye ne-neurotrophic properties, enye yezona zinto zinomdla kakhulu kwi-7,8-dihydroxyflavone inamandla okuxhasa impilo yengqondo kunye nokuphucula umsebenzi wokuqonda. Uphando lubonisa ukuba le khompawundi isebenza njenge-neurotrophin enamandla, ivuselela ukukhula kunye nokuphila kwee-neurons engqondweni. Uphononongo kwizilwanyana zaselabhoratri lubonise ukuba i-7,8-DHF iphucula kakhulu inkumbulo nobuchule bokufunda. Ngokukhuthaza ukusekwa konxibelelwano olutsha lwe-synaptic kunye nokuphucula unxibelelwano phakathi kweeseli zengqondo, le khompawundi ithembisa ukuvula amandla ethu okuqonda. Ukongeza, i-7,8-dihydroxyflavone isebenzisana ne-brain receptors ye-serotonin, ebandakanyeka kulawulo lwemood. Ngokumodareyitha la ma-receptors, inokukwazi ukunciphisa iimpawu zokuxhalaba kunye nokudakumba.

Umsebenzi we-7,8-Dihydroxyflavone
1) Ukuphucula iMekori kunye nokuFunda
2) Khuthaza ukulungiswa kweBrain
I-7,8-DHF ikhuthaze ukulungiswa kwee-neurons ezonakalisiweyo.
3) Yiba Neuroprotective
4) Ineempembelelo ze-Antioxidant
5) Ineempembelelo ezichasene nokudumba
I-7,8-DHF inciphisa ukukhutshwa kwezinto ezivuthayo kwiiseli zengqondo ngokuthintela i-NF-κB.
6) I-7,8-DHF inefuthe elinamandla lonyango kwi-Alzheimer's disease, kwaye inokuthintela ukutyeba ngokuvula i-muscle TrkB.

Ukusetyenziswa kwe-7,8-Dihydroxyflavone
I-7,8-Dihydroxyflavone (7,8-DHF) yiflavone evela ngokwendalo efumaneka kwi-Godmania aesculifolia, i-Tridax procumbens, kunye namagqabi omthi weprimula. Ifunyenwe ukuba isebenze njenge-agonist enamandla kwaye ikhethiweyo encinci ye-molecule ye-tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), i-receptor ephambili yomqondiso we-neurotrophin brain-derived neurotrophic factor (BDNF). I-7,8-DHF yomibini i-bioavailable yomlomo kwaye iyakwazi ukungena kumqobo wegazi-ingqondo. Iprodrug ye-7,8-DHF ephuculwe kakhulu amandla kunye ne-pharmacokinetics, i-R7, iphantsi kophuhliso lonyango lwe-Alzheimer's disease...