I-Paclitaxel yi-monomer diterpenoid compound ekhutshwe kwi-Natural Plant Paclitaxel bark, luhlobo lwe-metabolites yesibini eyinkimbinkimbi, okwangoku iqondwa kuphela iyeza elinokukhuthaza i-polymerization ye-microtubule kunye nokuzinza kwee-microtubules ziye zahlanganiswa.Ukulandela isotopu kubonise okopaclitaxelyayibotshelelwe kuphela kwii-microtubules ezenziwe nge-polymerized, kungekhona kwi-tubulin ye-polymerized ezimbini.Uqhagamshelwano lweselipaclitaxelemva kokuqokelelwa kwenani elikhulu lee-microtubules kwiiseli, eziphazamisa ukuqokelelwa kwe-microtubule yemisebenzi eyahlukeneyo yeselula, ngakumbi i-cell division stop kwi-mitosis, ithintela ukuhlukana kweeseli eziqhelekileyo.
Igama leMveliso: Paclitaxel99.0%
Ifom: Umgubo omhlophe wekristale
Inkcazo: 99%
Indlela yoVavanyo : HPLC
Inombolo yeCAS: 33069-62-4
Ifomula yemolekyuli:C47H51NO14
Indawo yokubilisa:957.115 °C kwi-760 mmHg
Ubunzima beMolekyuli: 853.91
Isimo se-GMO:GMO Mahala
Ukupakisha: kwi-25kgs fiber drums
Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo
Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa
Umsebenzi:
I-1.Paclitaxel isetyenziswa ikakhulu kumhlaza we-ovarian kunye nomhlaza wamabele, umhlaza wemiphunga, umhlaza we-colorectal, i-melanoma, umhlaza wentloko kunye nentamo, i-lymphoma, kwaye inefuthe elithile kwi-brain tumors.
I-2.Iziyobisi ezizinzileyo ezinokukhuthaza i-polymerization ye-microtubule kunye ne-microtubule polymerization.
I-3.Kuya kuqokelelwa inani elikhulu le-microtubules kwiiseli emva kokuvezwa kwi-paclitaxel, ukuqokelela kwe-microtubules kuphazamisa imisebenzi yeseli, ngokukodwa, ukuyeka ukuhlukana kweeseli kwi-mitosis, ukuvimbela ukuhlukana kweeseli eziqhelekileyo.
Isicelo:
Isetyenziswe kwisifundo sesakhiwo kunye nomsebenzi we-microtubles kwi-tubulin.I-Paclitaxel ngoku isetyenziselwa ukunyanga abaguli abanomhlaza wemiphunga, i-ovarian, umhlaza wamabele, umhlaza wentloko nentamo, kunye neendlela eziphambili zeKaposi's sarcoma.I-Paclitaxel yi-mitotic inhibitor esetyenziswa kwi-chemotherapy yomhlaza.
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