S-adenosyl-L-methionine disulfate tosylate

S-adenosyl-L-methionine disulfate tosylate Umfanekiso obonakalayo
  • S-adenosyl-L-methionine disulfate tosylate

Inkcazelo emfutshane:

I-Adenosyl-L-methionine disulfate tosylate (i-SAMe) sisongezelelo sokutya esisetyenziselwa ukunyanga ukudakumba kunye nesifo sesibindi. Kwakhona i-metabolite ye-amino acid methionine, eyenziwa yi-enzyme S-adenosylmethionine synthase.

I-S-Adenosyl-L-methionine ibizwa ngokulula njenge-SAMe okanye i-SAM-e eMelika, kwaye ikwabizwa ngokuba yi-AdoMet okanye i-SAM. Amagama e-S-adenosyl methionine kunye ne-S-adenosylmethionine athetha into efanayo i-S-Adenosyl-L-methionine. Ikhona ngokwemvelo emzimbeni womntu kwaye idlala indima ebalulekileyo kwiintlobo zokusabela emzimbeni.


  • FOB ixabiso:US $ 0.5 - 2000 / KG
  • Min.Ubungakanani boMyalelo:1KG
  • Ukubonelela ngezakhono:I-10000 KG / ngenyanga
  • Izibuko:SHANGHAI/BEIJING
  • Immimiselo yokuhlawula:L/C,D/A,D/P,T/T
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    Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Igama leMveliso:S-adenosyl-L-methionine disulfate tosylate

    Elinye Igama:Ademetionine disulfate tosylate; I-AdeMethionine Disulfate Tosylate; I-SAM-TAdemetionine disulfate tosylate; I-Ademetionine Disulfate Tosylate (SAM)

    Inombolo yeCAS:97540-22-2

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    I-SAMe inikela ngeqela le-methyl kwiintlobo ze-biosynthesis yeeprotheni, ii-neurotransmitters, i-nucleic kunye ne-nucleic acid. Oku kwenzeka kwiimpendulo ezininzi ze-enzymatic transmethylation.

     

    I-Adenosylmethionine (SAMe) yikhompawundi eyenzeka ngokwemvelo efumaneka phantse kuzo zonke izihlunu kunye nolwelo emzimbeni. Ibandakanyeka kwiinkqubo ezininzi ezibalulekileyo. I-SAMe idlala indima kwi-immune system, igcina i-membrane zeseli, kwaye inceda ukuvelisa kunye nokuphula iikhemikhali zengqondo, ezifana ne-serotonin, i-melatonin, kunye ne-dopamine.

     

    Ukuthatha i-SAMe ngomlomo kubonakala kusebenza malunga ne-ibuprofen kunye namanye amachiza afanayo ekunciphiseni iimpawu ze-osteoarthritis. Kodwa abantu abaninzi kufuneka bathathe i-SAMe isithuba esingangenyanga phambi kokuba bazive bengcono.

     

    Abantu ngokubanzi basebenzisa i-SAMe ukunyanga uxinzelelo, i-osteoarthritis kunye nesifo sesibindi. Nangona kunjalo, i-SAMe inokunxibelelana namayeza okudakumba.

     

    Isenokukhupha izinto eziyingozi emzimbeni. Ezi ziquka iintsimbi ezinzima. Inokuthintela umonakalo wesibindi kwityhefu ye-acetaminophen kwaye incede ukukhusela idiphozithi yamafutha kwisibindi sakho. Isenokunceda ukuthomalalisa ukudinwa kunye nokunciphisa umngcipheko wokukrala kwangoko.

     

    Kwiiseli ze-eukaryotic, i-SAM isebenza njengomlawuli weenkqubo ezahlukeneyo ezibandakanya i-DNA, i-tRNA, kunye ne-rRNA methylation; impendulo yomzimba; i-amino acid metabolism; ukutshintshwa kwe-sulfuration; kunye nokuninzi. Kwizityalo, i-SAM ibalulekile kwi-biosynthesis ye-ethylene, i-hormone yesityalo esibalulekileyo kunye ne-molecule yomqondiso.

    I-T-Adenosylmethionine (SAMe) yikhompawundi eyenzeka ngokwemvelo efumaneka phantse kuzo zonke izicubu kunye nolwelo emzimbeni. Ibandakanyeka kwiinkqubo ezininzi ezibalulekileyo. I-SAMe idlala indima kwi-immune system, igcina i-membrane zeseli, kwaye inceda ukuvelisa kunye nokuphula iikhemikhali zengqondo, ezifana ne-serotonin, i-melatonin, kunye ne-dopamine.

    Umsebenzi

    Transmethylation

    I-SAMe ngoyena mxhasi we-methyl ibalulekileyo emzimbeni, kwaye ubuncinci i-35 ezahlukeneyo ze-methyl transferase reactions zifunyenwe zifuna i-SA M njengomxhasi we-methyl. I-SAM isetyenziselwa i-biosynthesis yezinto ezininzi ze-nitrogen, ezifana ne-creatine, i-choline, i-epinephrine, i-pinecone, i-carnitine, kunye ne-myosin.

    Isenzo seTransaminopropyl

    I-SAMe ithatha inxaxheba kwi-synthesis ye-bioamines nge-transaminopropyl. I-Spermidine kunye ne-spermidine zibalulekile iipolyamines kwi-eukaryotes. Emva kwee-deshutters ezimbini, i-SAM ivelisa i-5 '-methiodophyl (MTA), ize idlulisele i-aminopropyl kwi-putriamine okanye kwi-spermidine ukuvelisa i-spermidine ehambelanayo kunye ne-spermidine.

    Isenzo sesulfure

    I-SAMe yi-precursor esebenzayo ye-sulfur-containing compounds ezifana ne-cysteine ​​​​kunye ne-glutathione (GSH). I-SAM ivelisa i-homocysteine ​​​​ngokuguqulwa kwesulfure, ilandelwa yi-catabolic generation ye-cysteine, ethi ke ihlaziywe ibe yi-glutathione (GS H).

    Isicelo

    Unyango lwe-hepatitis yentsholongwane

    Njenge-adenosylmethionine yangaphandle, i-S-adenosylmethionine inokuncedisa i-adenosylmethionine engapheliyo kubantwana abanomonakalo wesibindi, ukunciphisa ngokufanelekileyo ukujikeleza kwe-enterohepatic ye-cholic acid, ukukhusela iiseli zesibindi ezonakalisiweyo, kunye nokukhuthaza ukubuyiswa kwe-jaundice. Ukongezelela, i-S-adenosine methionine nayo iyasebenza kunyango lwe-infantile isibindi syndrome.

    Unyango lwesifo sesibindi esinxilisayo

    Izifundo ziye zafumanisa ukuba i-s-adenosine kunyango lwezigulane ezine-hepatitis enxilisayo inokuphucula ngokubonakalayo ukungatyeki kwabo, isicaphucaphu, ukugabha, ukudinwa, ukudinwa kwesisu, ukurhawuzelelwa kwesikhumba kunye nezinye iimpawu, kwangaxeshanye ekunciphiseni i-serum bilirubin kunye nokuphucula ukusebenza kwesibindi. inesiphumo esihle, kunye nokusetyenziswa okukhuselekileyo, akukho zichaso ezicacileyo ezicacileyo ezifunyenwe kwinkqubo yonyango. Kodwa unyango lwe-hepatitis enxilisayo, ukuyeka utywala kubaluleke kakhulu, ikwayeyona ndlela yonyango isisiseko.

    Unyango lwe-Intrahepatic cholestasis yokukhulelwa

    I-S-adenosyl-L-methionine powder inokuphucula kakhulu izibonakaliso ze-biochemical ze-cholestasis kunye neempawu ze-prurituria, ngoko kucatshangelwa ukuba i-S-adenosine yenye yeziyobisi ezikhuselekileyo nezisebenzayo kunyango lwe-intrahepatic cholestasis.

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