Igama lemveliso:I-Tianeptine Hemisulfate Monohydrate

Elinye Igama:tianeptinesulfate;

(Thiazepin-11-ylAmino)HeptanoicAcidSemisulfateMonohydrateTianeptineSemisulfateMonohydrate;

7 - [(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo [c,f] [1,2] thiazepin-11-yl) amino]heptanoicacidsulfatehydrate (2: 1: 2); I-Tianeptinehemisulfatemonohydrate(THM);

7 - [(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo [c,f] [1,2] thiazepin-11-yl) amino]heptanoicacidsulfatehydrate (2: 1: 2); Tianeptinehemisulfatehydrate;Thiazepin-11-ylAmino)HeptanoicAcidSemisulfate;THM

Inombolo yeCAS:1224690-84-9

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I-Tianeptine Sulfate / Tianeptine hemisulfate monohydrate yityuwa ephuculweyo yeTianeptine. Akuyona i-hygroscopic ngoko ukuphatha umgubo kulula kakhulu. Ekubeni ingekho ngokukhawuleza kwaye ikhutshwe emzimbeni, ityuwa ye-sulfate ivumela ukukhululwa okulawulwayo ngakumbi kwe-Tianeptine kwixesha elide. Endaweni yokuba udose kathathu ngeziphumo ezikhawulezayo kunye neziphumo eziwa ngokukhawuleza, ityuwa yesulfate ivumela idosi enye ukugcina amanqanaba eplasma emzimbeni ixesha elide kunetyuwa yesodium. Ezi mpawu ziphuculweyo zenza i-Tianeptine Sulfate idibaniso yenoveli.

I-Tianeptine Sulfate yayingeyona nje i-antidepressant enhle kunye neempendulo ezimbi kakhulu ngaphantsi kweziyobisi eziqhelekileyo ze-antidepressant tricyclic, phantse akukho miphumo emibi kwi-cardiovascular system, igazi, isibindi kunye nemisebenzi yezintso ayizange ibuhlungu, kwaye andinayo impembelelo yokuzola. I-Tianeptine ayisebenzi kuphela ukudakumba kunye ne-neurosis edandathekileyo, utywala obungapheliyo kunye nokudakumba emva kotywala buyasebenza. Ukusetyenziswa kwexesha elide kunokuthintela ukuphindaphinda

I-Tianeptine hemisulfate monohydrate, eyaziwa ngokuba yi-tianeptine sulfate, yinto ekhethekileyo eyafunyanwa okokuqala kwi-1960s kwaye isetyenziswe ngokubanzi ukususela ngoko.

I-Tianeptine yi-antidepressant. Isilwanyana sineeseli ze-hippocampus pyramidal zokwandisa umsebenzi ozenzekelayo, kwaye ukukhawulezisa umsebenzi wayo kwakuvinjelwe emva kokubuyisela; ukwanda kwe-cortical kunye ne-hippocampalneurons kwiindawo ze-5-serotonin reuptake. I-Tianeptine ngaphandle kokulandela imiphumo emibi: ukulala kunye nokuphaphama; inkqubo ye-cardiovascular system; inkqubo ye-cholinergic (ngaphandle kweempawu ze-anticholinergic); ukunqwenela iziyobisi.

I-Tianeptine liyeza elimiselweyo elisetyenziselwa ukuphucula ukudakumba kuzo zonke iindidi zobunzima. Iyeza le-tianeptine lichazwa ngokubanzi njenge-tricyclic antidepressant. Le yikhemikhali ebizwa ngokuba yikhemikhali ngenxa yokuba inezangqa ezintathu zeeathom.

Njengezinye i-tricyclic antidepressants, i-tianeptine ivimba ukuphinda kuthathwe, okanye ukufunxa kwakhona, kwe-serotonin. Le yi-neurotransmitter enoxanduva lwengqondo yomntu yokuphila kakuhle. Ukuphinda kuthathwe kwakhona kwandisa ubukho bezinto ezinjalo engqondweni.

I-Tianeptine hemisulfate monohydrate, eyaziwa ngokuba yi-tianeptine sulfate, yinto ekhethekileyo eyafunyanwa kuqala kwi-1960 kwaye isetyenziswe ngokubanzi ukususela ngoko.esebenza ngokunyusa ukuphindaphinda kwe-serotonin, i-neurotransmitter edlala indima ebalulekileyo ekulawuleni isimo sengqondo kunye nomoya. . Ngokuphucula i-serotonin reuptake, i-tianeptine hemisulfate monohydrate inceda ukubuyisela ukulingana kweekhemikhali engqondweni, okunokunciphisa iimpawu zokudakumba. Enye yeempawu ezizodwa ze-tianeptine hemisulfate monohydrate kukukwazi kwayo ukonyusa i-neuroplasticity. I-Neuroplasticity ibhekisa kumandla engqondo okutshintsha kunye nokuziqhelanisa ngokuhamba kwexesha. Uphando lubonisa ukuba i-tianeptine hemisulfate monohydrate ikhuthaza ukukhula kwee-neurons ezintsha kwaye yomeleza uxhulumaniso olukhoyo kwingqondo. Le propati yenza kube yinto enomdla yokunyanga ukudakumba, njengoko inokubonelela ngeenzuzo zexesha elide ngaphezu kokukhululeka kweempawu.

Umsebenzi:

I-Tianeptine Sulfate yi-antidepressant. Isilwanyana sinalo: iiseli ze-hippocampus pyramidal zandisa umsebenzi ozenzekelayo, kwaye ukukhawuleza umsebenzi wayo wawunqandekile emva kokubuyiselwa; ukwanda kwe-cortical kunye ne-hippocampal neurons kwiindawo ze-5-serotonin reuptake. I-Tianeptine ngaphandle kokulandela imiphumo emibi: ukulala kunye nokuphaphama; inkqubo ye-cardiovascular system; inkqubo ye-cholinergic (ngaphandle kweempawu ze-anticholinergic); ukunqwenela iziyobisi.
I-Tianeptine Sulfate yayingeyona nje i-antidepressant enhle kunye neempendulo ezimbi kakhulu ngaphantsi kweziyobisi eziqhelekileyo ze-antidepressant tricyclic, phantse akukho miphumo emibi kwi-cardiovascular system, igazi, isibindi kunye nemisebenzi yezintso ayizange ibuhlungu, kwaye andinayo impembelelo yokuzola. I-Tianeptine ayisebenzi kuphela ukudakumba kunye ne-neurosis edandathekileyo, utywala obungapheliyo kunye nokudakumba emva kotywala buyasebenza. Ukusetyenziswa kwexesha elide kunokuthintela ukuphindaphinda.

Isicelo:

I-Tianeptine hemisulfate monohydrate yinto ekhethiweyo ye-serotonin i-reuptake enhancer (SSRE), oku kuthetha ukuba iphakamisa ukuphindaphinda kwe-serotonin kwingqondo, ngaloo ndlela inyusa i-synaptic plasticity kunye nokuphucula isimo sengqondo. Isebenza ngokuguqula amanqanaba e-serotonin kwingqondo kunye nokukhuthaza i-neuroplasticity. Kwiminyaka yakutshanje, i-tianeptine hemisulfate monohydrate iye yanda kakhulu kuphando lwezonyango, ngakumbi kuphuhliso lweziyobisi ezichasayo. Njengoko uphando oluninzi luqinisekisa umphumo walo wonyango, amathuba okusetyenziswa kwawo avela ngokuthe ngcembe