Igama lemveliso:IAgomelatine

Elinye Igama:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

Inombolo yeCAS:138112-76-2

Iinkcukacha: 99.0%

Umbala: Umgubo omhlophe ococekileyo onevumba elibonakalayo kunye nencasa

Isimo se-GMO:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

IAgomelatineluhlobo olutsha lwe-antidepressant. Indlela yokusebenza kwayo iphula inkqubo ye-monoamine transmitter system.I-Agomelatine yi-agonist ye-melatoninergic kunye ne-antagonist ekhethiweyo ye-5-HT2C receptors, kwaye ibonakaliswe ukuba iyasebenza kwiimodeli ezininzi zezilwanyana zokudakumba. I-Agomelatine (S20098) ibonise ixabiso le-pKi ye-6.4 kunye ne-6.2 kwindalo (i-porcine) kunye ne-cloned, abantu (h) i-5-hydroxytryptamine (5-HT) i-2C receptors, ngokulandelanayo.

I-Agomelatine lolunye uhlobo lomgubo omhlophe-omhlophe okanye omhlophe wekristale okanye oqinileyo omhlophe. I-IUPAC Igama lale khemikhali yi-N-[2-(7-methoxynaphthalen-1-yl) ethyl]acetamide. Le khemikhali yeyeeCompounds zeAromatics;Aromatics;Neurochemicals;APIS. Kufuneka igcinwe ku -20°C kwisikhenkcisi.

 
Njenge-Pharmaceutical Intermediates, i-Agomelatine isetyenziselwa unyango lwengxaki enkulu yokudakumba, ukuphazamiseka kwengqondo. I-Agomelatine isetyenziswa kunyango lwengxaki enkulu yokudakumba, ukuphazamiseka ngokweemvakalelo. Into yechiza leNervous System. I-Antidepressant, i-anxiolytic, ukulungelelanisa isingqisho sokulala kunye nokulawula iwotshi yebhayoloji. I-Agomelatine yi-agonist ye-melatoninergic kunye ne-antagonist ekhethiweyo ye-5-ht2c receptors. I-Agomelatine lichiza lokuthomalalisa uxinzelelo. Ihlelwa njenge-norepinephrine-dopamine disinhibitor (NDDI) ngenxa yokuchasana kwayo ne-5-HT2C receptor. I-Agomelatine ikwayi-agonist enamandla kwi-melatonin receptors eyenza ibe yi-melatonergic antidepressant yokuqala.

.I-Agomelatine inxulumene ngokusondeleyo ne-melatonin. I-Agomelatine i-agonist enamandla kwi-melatonin receptors kunye nomchasi kwi-serotonin-2C (5-HT2C) i-receptors, ihlolwe kwimodeli yezilwanyana zokudakumba.

I-Agomelatine sisithomalalisi sokudakumba esisetyenziselwa ukunyanga ukudakumba.

Ingqondo idla ngokwenza kakuhle ekuqinisekiseni ukuba sinemichiza eyaneleyo esiyidingayo ukuze sisebenze kakuhle. Kodwa ukudakumba kunokuchaphazela inani leekhemikhali zengqondo.

Ezi khemikhali ziquka i-noradrenaline, i-dopamine kunye ne-serotonin; ukudakumba kunciphisa amanqanaba aba bathumeli bobuchopho. Uxinezeleko lukwachaphazela umchiza obizwa ngokuba yimelatonin. Ukuncipha kwemelatonin kunxulunyaniswa nokuphazamiseka kwindlela esilala ngayo.

I-Agomelatine yi-antidepressant yokuqala yokwandisa umsebenzi we-melatonin ngokuthe ngqo. Ikwenza oku ngokusebenza njengemelatonin kwiindawo ekujoliswe kuzo apho imelatonin isebenza khona. (Ezi zaziwa njenge melatonin receptors). Ngokunyusa umsebenzi we-melatonin, i-agomelatine ikwanyusa ngokuthe ngqo umsebenzi we-noradrenaline kunye ne-dopamine.

I-Agomelatine yasungulwa okokuqala eYurophu ngo-2009 kwaye ngoku ivunyiwe ukuba isetyenziswe kumazwe angaphezu kwama-70. Ngokungafaniyo ne-antidepressants yendabuko, i-agomelatine isebenza ngokujolisa i-melatonin kunye ne-serotonin receptors kwingqondo. Ngokusebenza njenge-agonist kwi-melatonin receptors, i-agomelatine inceda ukulungisa iipatheni eziphazamisekileyo zokulala zihlala zinxulunyaniswa nokudakumba. Lo matshini awuncedi nje ukuphucula umgangatho wokulala kodwa ukwanceda ukubuyisela izingqisho zendalo ze-circadian. Ukongezelela, i-agomelatine yenza njengomchasi kwi-receptors ethile ye-serotonin (i-5-HT2C receptors). Esi senzo sintlu-mbini sikhethekileyo sonyusa ngokungangqalanga ukufumaneka kwe-serotonin engqondweni, i-neurotransmitter enoxanduva lokulawula imo. Ngokulawula amanqanaba e-serotonin, i-agomelatine inokusebenza njenge-antidepressant esebenzayo, ukukhulula iimpawu ezinjengosizi, ukulahlekelwa ngumdla, ukuziva unetyala okanye ukungabi naxabiso. Ukongeza, i-agomelatine inokubonelela ngezinye izibonelelo. Uphando lucebisa ukuba lunokunceda ukuphucula umsebenzi wokuqonda Uphando lubonisa amandla alo okuphucula inkumbulo, ingqalelo, kunye nomsebenzi wesigqeba, oko kuyenza ibe yindawo enomdla yophando lwexesha elizayo.

Umsebenzi:

I-Agomelatine inokunceda ukulawula 'iwotshi yomzimba' (i-circadian rhythm) kunye neenzuzo ezilungileyo kwimood kunye noxinzelelo lwe-sleein I-Agomelatine isetyenziswa kunyango lokudakumba okanye ukunceda ukuthintela ukudakumba ukuba kubuye, kwaye ifumaneka yodwa ngomyalelo kagqirha. Iimpawu zokudakumba ziyohluka kumntu omnye komnye, kodwa ngokuqhelekileyo ziquka ukudakumba okuzingisileyo, ukuphelelwa ngumdla kwizinto ozithandayo, ukuziva ungento yanto, iingxaki zokulala, ukuziva ucotha, ukuxhalaba okanye utshintsho kumdla wokutya kunye nobunzima. Utshintsho kubuthongo bakho bemihla ngemihla kunye neepateni zokutya yimizekelo yokuphazamiseka kwewotshi yomzimba wakho okwenzeka rhoqo ukudakumba.