Igama lemveliso:Syringae Cortex Extract

Elinye iGama:i-lilac yaseJapan (syringa reticulata);I-Syringa reticulata amurensis;I-Syringa reticulata amurensis;I-Syringa reticulata (Bl.)Hara var.mandshurica (Maxim.) Hara

Umthombo weBotanic:Syringae Cortex Bark

Igama lesiLatini:Syringa reticulata (Blume) Hara var.amurensis (Rupr.) Pringle

Isivavanyi:Eleutheroside b, I-Oleuropein

Inombolo yeCAS:118-34-3, 32619-42-4

Umbala: Umgubo otyheli-mdaka onevumba elibonakalayo kunye nencasa

Inkcazo:Eleutheroside b5% + Oleuropein 20%;Eleutherosideb 8%+Oleuropein 35%;Eleutherosideb 10%;Eleutheroside b 98%;

Isimo se-GMO:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

I-Syringae Folium (SF), ephawulwe kwi-Chinese Pharmacopeia, isetyenziswe kumayeza e-herbal ukunyanga izifo ezivuthayo kunye nesicatshulwa saso samanzi se-SF, i-Yanlixiao (YLX) esisilungiselelo sorhwebo amayeza emveli aseTshayina asetyenziswe ngokubanzi kwiklinikhi ngokuchasene nokuvuvukala kwamathumbu.Ukuphonononga isiseko sayo sezinto zonyango ze-SF, i-fraction esebenzayo esuka kwi-SF (ESF) yafunyanwa ngokuhlukaniswa kwe-bio-guided kunye nokutyetyiswa kwamacandelo asebenzayo.Kolu phando, i-ESF ichongiwe njengeqhezu elichasene nokudumba ngokuthelekisa izinga lokusinda kwimodeli yegundane yokudumba eyenziwe yi-LPS.I-in vivo ye-anti-inflammation efficacy ye-ESF yavavanywa ngakumbi yi-mouse ear edema model.Iinqununu ezilishumi elinesihlanu eziphambili ze-ESF zahlulwa kwi-ESF emva kokuchongwa yi-UPLC-TOF-MS, kunye nokuvinjelwa kwabo kwi-lipopolysaccharide (LPS) -imveliso ye-nitric oxide (NO) eyenziwe yavavanywa kunye ne-ESF kwi-RAW 264.7 macrophages cell line.Ngenjongo yokukhangela iindlela zayo zokuchasana nokudumba, uphando lwe-pharmacology lwenethiwekhi lwenziwa ngokusekelwe kumacandelo asebenzayo.Njengeziphumo, i-ESF ifunyenwe ngokusebenza okungcono ekuvimbeleni ukuvuvukala kwendlebe (82.2 mg / kg, 43.7%) xa kuthelekiswa ne-YLX (293.3 mg / kg, 37.9%).Okwangoku, iinqununu eziphambili ze-ESF, i-luteolin kunye ne-quercetin zifunyenwe ngempumelelo enkulu ekunciphiseni i-NO imveliso xa kuthelekiswa ne-aminoguanidine (ulawulo oluhle) (81.3%, 78.7% kunye ne-76.3%, ngokulandelanayo, i-50 μg / ml).Uhlalutyo lwe-pharmacology yenethiwekhi lucebise ukuba i-luteolin kunye ne-quercetin ingaba yinxalenye ebalulekileyo yomsebenzi wokulwa nokuvuvukala kwe-ESF, kunye ne-NFKB1, i-RELA, i-AKT1, i-TNF kunye ne-PIK3CG zichongiwe njengeenjongo eziphambili kunye ne-MAPK, NF-κB, TCR kunye ne-TLRs yokubonisa iindlela zingabandakanyeka kwisenzo sokulwa nokuvuvukala kwe-ESF.Iziphumo ezifunyenwe kolu phononongo zibonise ukuba i-ESF inamandla okuphuhliswa njenge-agent echasene nokudumba esetyenziswa eklinikhi.

I-Syringae Cortex Extract yimveliso edibeneyo ekhutshwe kwi-Syringa reticulata, kwaye izithako zayo eziphambili ziyi-Eleutheroside b kunye ne-Oleuropein.

I-Eleutheroside liqela lee-compounds ezahlukeneyo ezihlukanisiwe kwiingcambu ze-Acanthopanax senticosus, ezithengiswa ngokuthengiswa ngokukodwa kwiincindi.I-Eleutheroside B (i-syringin) yi-phenyl propyl glycosides enokusetyenziswa njengamalungiselelo e-herbal aseTshayina kunye nezongezo zokutya ze-Eleutherococcus senticosus.

I-Oleuropein yikhompawundi ye-iridoid yesibini ye-glycosylated, eyikhompawundi ekrakra yephenolic ekhoyo kwixolo lomnquma oluhlaza, ipulp, imbewu, kunye namagqabi.Idla ngokufumaneka kwiminquma, kodwa kukwakho nenxalenye ye-syringae cortex malunga nobukho bayo, ngokungathandabuzekiyo ibonelela ngesicatshulwa se-syringae cortex enesiphumo esikhulu ngakumbi.