Igama Lomkhiqizo:7,8-Dihydroxyflavone

I-CASNo:38183-03-87

Elinye Igama:I-7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;

I-DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;

7,8-dihydroxy-2-phenyl-1-benzopyran-4-one,,I-8-Dihydroxyflavone (7,8-DHF)

Imininingwane:98.0%

Umbala:Okuphuziimpushana enephunga sici nokunambitha

I-GMOIsimo:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-7,8-Dihydroxyflavone, eyaziwa nangokuthi i-7,8-DHF, i-flavonoid eyenzeka ngokwemvelo etholakala ezinhlobonhlobo zezitshalo, kuhlanganise ne-Tridacna tridacna. Eyaziwa ngezindawo zayo ze-antioxidant kanye ne-neurotrophic, enye yezinto ezithakazelisa kakhulu ze-7,8-dihydroxyflavone amandla ayo okusekela impilo yobuchopho kanye nokuthuthukisa ukusebenza kwengqondo.

7,I-8-Dihydroxyflavone (7,8-DHF) iyi-agonist enamandla futhi ekhethayo ye-TrkB receptor (Kd≈320 nM). I-TrkB receptor iyisamukeli sesignali esiyinhloko se-neurotrophic factor ephuma ebuchosheni. I-7,8-Dihydroxyflavone (7,8-DHF) i-nootropic engaba khona engase ithuthukise impilo yonke yobuchopho, isimo sengqondo, nokusebenza kwengqondo. Kungase futhi kube yinzuzo ezinkingeni eziningana ze-neurodeergenerative kanye ne-neurodevelopmental, kanye nokukhuluphala kanye nomfutho wegazi ophakeme.

I-7,8-Dihydroxyflavone, eyaziwa nangokuthi i-7,8-DHF, i-flavonoid eyenzeka ngokwemvelo etholakala ezinhlobonhlobo zezitshalo, kuhlanganise ne-Tridacna tridacna. Eyaziwa ngezindawo zayo ze-antioxidant kanye ne-neurotrophic, enye yezinto ezithakazelisa kakhulu ze-7,8-dihydroxyflavone amandla ayo okusekela impilo yobuchopho kanye nokuthuthukisa ukusebenza kwengqondo. Ucwaningo lubonisa ukuthi le nhlanganisela isebenza njenge-neurotrophin enamandla, ekhuthaza ukukhula nokuphila kwama-neurons ebuchosheni. Ucwaningo ezilwaneni zaselabhorethri lubonise ukuthi i-7,8-DHF ithuthukisa kakhulu inkumbulo nekhono lokufunda. Ngokugqugquzela ukwakheka kokuxhumana okusha kwe-synaptic kanye nokuthuthukisa ukuxhumana phakathi kwamaseli obuchopho, le nhlanganisela ithembisa ukuvula amandla ethu okuqonda. Ukwengeza, i-7,8-dihydroxyflavone isebenzisana nama-serotonin receptors obuchopho, abandakanyeka ekulawulweni kwemizwa. Ngokuguqula lawa ma-receptors, ingakwazi ukunciphisa izimpawu zokukhathazeka nokucindezeleka.

Umsebenzi we-7,8-Dihydroxyflavone
1) Thuthukisa Inkumbulo Nokufunda
2) Khuthaza Ukulungisa Ubuchopho
I-7,8-DHF ikhuthaze ukulungiswa kwezinzwa ezilimele.
3) Yiba Neuroprotective
4) Ine-Antioxidant Effects
5) Ine-Anti-Inflammatory Effects
I-7,8-DHF inciphisa ukukhululwa kwezinto ezivuthayo emangqamuzaneni obuchopho ngokuvimbela i-NF-κB.
6) I-7,8-DHF inomphumela onamandla wokwelapha ku-Alzheimer's disease, futhi inganqanda ukukhuluphala ngokuvula imisipha TrkB.

Ukusetshenziswa kwe-7,8-Dihydroxyflavone
I-7,8-Dihydroxyflavone (7,8-DHF) iyiflavone eyenzeka ngokwemvelo etholakala ku-Godmania aesculifolia, i-Tridax procumbens, kanye namaqabunga esihlahla se-primula. Kutholwe ukuthi isebenza njenge-agonist enamandla futhi ekhethayo ye-molecule encane ye-tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), isamukeli esiyinhloko esisayinayo se-neurotrophin brain-derived neurotrophic factor (BDNF). I-7,8-DHF kokubili itholakala ngomlomo futhi iyakwazi ukungena kumgoqo wegazi nobuchopho. Umuthi we-7,8-DHF onamandla athuthuke kakhulu kanye ne-pharmacokinetics, u-R7, usathuthukiswa ukwelapha isifo i-Alzheimer's…