Igama Lomkhiqizo:I-Syringae Cortex Extract

Elinye Igama: I-lilac yaseJapane (syringa reticulata);I-Syringa reticulata amurensis;I-Syringa reticulata amurensis;I-Syringa reticulata (Bl.)Hara var.mandshurica (Maxim.) Hara

Umthombo we-Botanic:Syringae Cortex Bark

Igama lesiLatini:Syringa reticulata (Blume) Hara var.amurensis (Rupr.) Pringle

Isivivinyo:Eleutheroside b, I-Oleuropein

Inombolo ye-CAS:118-34-3, 32619-42-4

Umbala: Impushana ephuzi ngokunsundu enephunga nokunambitha

Ukucaciswa:Eleutheroside b5%+Oleuropein 20%;Eleutherosideb 8%+Oleuropein 35%;Eleutherosideb 10%;I-Eleutheroside b 98%;

Isimo se-GMO:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-Syringae Folium (SF), ephawulwe ku-Chinese Pharmacopeia, isetshenziswe emithini yamakhambi ukwelapha izifo ezivuvukalayo kanye nokukhishwa kwayo kwamanzi e-SF, Yanlixiao (YLX) okuwukulungiselela ukuhweba umuthi wendabuko waseShayina usetshenziswe kabanzi emtholampilo ngokumelene nokuvuvukala kwamathumbu.Ukuhlola isisekelo sayo sezinto zokwelapha ze-SF, ingxenye esebenzayo evela ku-SF (ESF) itholwe ngokuhlukaniswa okuqondiswa yi-bio kanye nokunothiswa kwezingxenye ezisebenzayo.Kulolu cwaningo, i-ESF ihlonzwe njengengxenye elwa nokuvuvukala ngokuqhathanisa izinga lokusinda kwemodeli yegundane yokuvuvukala eyenziwe yi-LPS.Ukusebenza kahle kwe-in vivo anti-inflammation kwe-ESF kwaphinde kwahlolwa ngemodeli ye-mouse edema yendlebe.Izingxenye eziyinhloko eziyishumi nanhlanu ze-ESF zahlukaniswa ku-ESF ngemva kokukhonjwa yi-UPLC-TOF-MS, futhi ukuvinjelwa kwazo ekukhiqizeni i-lipopolysaccharide (LPS)-induced nitric oxide (NO) kwahlolwa kanye ne-ESF ku-RAW 264.7 macrophages cell line.Ihlose ukusesha izindlela zayo zokulwa nokuvuvukala, ucwaningo lwe-pharmacology lwenethiwekhi lwenziwa ngokusekelwe ezingxenyeni eziyinhloko ezisebenzayo.Njengemiphumela, i-ESF itholakale ngokusebenza kangcono ekuvimbeleni ukuvuvukala kwendlebe (82.2 mg / kg, 43.7%) uma kuqhathaniswa ne-YLX (293.3 mg / kg, 37.9%).Phakathi naleso sikhathi, izingxenye eziyinhloko ze-ESF, i-luteolin ne-quercetin zitholwe ngempumelelo enkulu ekunciphiseni ukukhiqizwa kwe-NO uma kuqhathaniswa ne-aminoguanidine (ukulawula okuhle) (81.3%, 78.7% kanye ne-76.3%, ngokulandelana, i-50 μg / ml).Ukuhlaziywa kwe-pharmacology yenethiwekhi kuphinde kwaphakamisa ukuthi i-luteolin ne-quercetin kungaba izingxenye ezibalulekile zomsebenzi wokulwa nokuvuvukala kwe-ESF, kanye ne-NFKB1, RELA, AKT1, TNF kanye ne-PIK3CG kukhonjwe njengokuhlosiwe okubalulekile kanye nokusayina kwe-MAPK, NF-κB, TCR kanye ne-TLRs. izindlela zingabandakanyeka esenzweni sokulwa nokuvuvukala kwe-ESF.Imiphumela etholwe kulolu cwaningo ibonise ukuthi i-ESF inamandla okuthuthukiswa njenge-ejenti elwa nokuvuvukala esetshenziswa emtholampilo.

I-Syringae Cortex Extract iwumkhiqizo oyinhlanganisela okhishwe ku-Syringa reticulata, futhi izithako zayo eziyinhloko i-Eleutheroside b ne-Oleuropein.

I-Eleutheroside iyiqembu lezinhlanganisela ezahlukene ezihlukanisiwe ezimpandeni ze-Acanthopanax senticosus, ezithengiswa kakhulu ngokwezindikimba.I-Eleutheroside B (i-syringin) yi-phenyl propyl glycosides engasetshenziswa njengamalungiselelo amakhambi aseShayina kanye nezithako zokudla ze-Eleutherococcus senticosus.

I-Oleuropein iyinhlanganisela ye-iridoid yesibili e-glycosylated, okuyinhlanganisela ye-phenolic ebabayo ekhona emakhasini omnqumo oluhlaza, uginindela, imbewu, namaqabunga.Ivamise ukutholakala eminqumeni, kodwa kukhona nengxenye ye-syringae cortex mayelana nokuba khona kwayo, ngokungangabazeki ehlinzeka nge-syringae cortex ekhishwe ngomphumela omkhulu kakhulu.