Igama Lomkhiqizo:YDL223C (I-HBT1) Impushana

Elinye Igama:I-HBT1,YDL223C

I-CASNo:489408-02-8

Imininingwane:99.0%

Umbala:Okuqinile okuphuzi ngokukhanyayonephunga sici kanye ukunambitheka

I-GMOIsimo:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-HBT1 i-molecule engabophezela kuphela endaweni ethile kuphrotheni ye-AMPA-R uma kukhona i-glutamate, futhi lokhu kubophezela kusiza ukulawula umsebenzi wephrotheni. Ama-receptors e-AMPA avezwa kulo lonke uhlelo lwezinzwa olumaphakathi futhi adlala indima ebalulekile ekuxhumaneni kwe-neuronal, ukucubungula izinzwa, ukufunda, inkumbulo, kanye ne-synaptic plasticity. Ama-receptors e-AMPA angabavikeli abakhulu ekudluliselweni kwemithambo-luvo okujabulisayo, alamula ngokushesha, ngokushesha aqede ukungezwani komzimba kuma-synapses amaningi, futhi abandakanyeka ekuphenduleni kwangaphambi kwesikhathi kwe-glutamate ezifundeni ze-synaptic. Ama-receptors e-AMPA avame ukuvezwa ngokubambisana nama-NMDA receptors kuma-synapses, futhi ndawonye akhuthaza izinqubo ze-synaptic plasticity ezibandakanyeka ekufundeni, inkumbulo, i-excitotoxicity, kanye ne-neuroprotection. I-brain-derived neurotrophic factor (BDNF) iyisici se-neurotrophic esidlala indima ebalulekile ekugcinweni nasekukhuliseni ama-neurons futhi sinemiphumela enamandla futhi eminingi ekwandeni, ukuhlukaniswa, ukusinda nokufa kwamaseli e-neuronal kanye ne-non-neuronal. , i-modulator ye-neurotransmitter efaka isandla ku-neuronal plasticity ekufundeni nasenkumbulo. Ngakho-ke, kubalulekile empilweni nasenhlalakahleni yesimiso sezinzwa.

Imisebenzi:

1. Yeast genomic knockout strain
   2. Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; eziguquguqukayo azinasici ekwakhekeni kokuqagela kokukhwelana, ngalokho
   ukufaka i-Hbt1p ku-polarized cell morphogenesis; I-HBT1 inepharalogi, i-YNL195C, evele kukho konke ukuphindaphindeka kofuzo
   3. Isetshenziswa emkhakheni wezokwelapha.
   4. Thuthukisa ubuhlakani bengqondo.
   5. Khulisa inkumbulo namandla okuncika.
   6. Thuthukisa izinga lokugqugquzela.
   7. Thuthukisa ukulawulwa kwendlela yobuchopho ekhohlo/ngaphansi.
   8. Thuthukisa ukuqonda kwezinzwa.
   9. Thuthukisa amandla obuchopho ukuxazulula izinkinga futhi uvikeleke kunoma iyiphi ikhemikhali noma ngokomzimba.

Izicelo:

I-HBT1 iyinoveli enamandla ye-AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] receptor] enomphumela ophansi we-agonistic uma iqhathaniswa ne-LY451395 ne-OXP1, idala ukukhiqizwa okususelwa ebuchosheni. I-neurotrophic factor (BDNF) futhi ibonisa umphumela omncane we-agonistic kuma-neuron ayinhloko. I-HBT1 ibophezela kusizinda esibopha i-ligand se-AMPA-R ku-glutamate dependent manner