Dzina lazogulitsa:Chinsinsi cha Ginger wakuda
Gwero la Botanic:Kaempferia parviflora.L
CASNo: 21392-57-4
Dzina Lina:5.7-Dimethoxyflavone
Zofotokozera: 5.7-Dimethoxyflavone ≥2.5%
Flavonoids yonse≥10%
Mtundu:Wofiiriraufa ndi khalidwe fungo ndi kukoma
Mtengo wa GMOMkhalidwe: GMO Yaulere
Kulongedza: mu 25kgs fiber ng'oma
Kusungirako: Sungani chidebe chosatsegulidwa pamalo ozizira, owuma, Khalani kutali ndi kuwala kwamphamvu
Shelf Life: Miyezi 24 kuyambira tsiku lopangidwa
5,7-Dimethoxyflavone ndi chimodzi mwa zigawo zikuluzikulu za Kaempferia parviflora, zomwe zimakhala ndi kunenepa kwambiri, zotsutsana ndi zotupa, komanso zotsutsana ndi zotupa.5,7-Dimethoxyflavone imalepheretsa cytochrome P450 (CYP) 3As.5,7-Dimethoxyflavone ndiwothandizanso poletsa khansa ya m'mawere (BCRP) inhibitor.
Ntchito mu Vitro:
Ntchito yabwino kwambiri mu vitro trypanocidal ya T. brucei rhodesiense inagwiritsidwa ntchito ndi 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng / ml), yotsatiridwa ndi 3-hydroxyflavone, rhamnetin, ndi 7,8,3′, 4'-tetrahydroxyflavone (IC50s, 0.5 microg/ml) ndi catechol (IC50, 0.8 microg/ml).?Zochita zotsutsana ndi T. cruzi zinali zochepa, ndipo Chrysin dimethylether ndi 3-hydroxydaidzein okha anali ndi IC50s zosakwana 5.0 microg/ml.
Mu Vivo Ntchito:
5,7-Dimethoxyflavone (10 mg/kg, pakamwa, kamodzi patsiku, kwa masiku 10) imatha kuchepetsa kuchuluka kwa mapuloteni a CYP3A11 ndi CYP3A25 pachiwindi cha mbewa [1].
5,7-Dimethoxyflavone (25 ndi 50 mg / kg, pakamwa) imatha kuletsa sarcopenia mu mbewa zachikulire [3].
5,7-Dimethoxyflavone (50 mg / kg / d, pakamwa, yokhalitsa kwa masabata a 6) ikhoza kuchepetsa kulemera ndi kuletsa chiwindi chamafuta mu mbewa za HFD [5].
MCE sinatsimikizire paokha kulondola kwa njirazi.Iwo ndi ongotchula chabe.
