Beta-nicotinamide Mononucleotide (NMN), chopangidwa ndi NAMPT reaction ndi NAD + yapakatikati yofunikira, imathandizira kusalolera kwa shuga pobwezeretsa milingo ya NAD + mu mbewa za T2D za HFD.NMN imathandiziranso kukhudzidwa kwa insulin ya chiwindi ndikubwezeretsanso mawonekedwe a jini okhudzana ndi kupsinjika kwa okosijeni, kuyankha kotupa, ndi nyimbo ya circadian, pang'ono kudzera mu kuyambitsa kwa SIRT1.NMN imagwiritsidwa ntchito pophunzira zomangira zomangira mkati mwa ma aptamers a RNA ndi ma activation a ribozyme okhudza β-nicotinamide mononucleotide (Beta-NMN)-yoyambitsa zidutswa za RNA.
Nicotinamide mononucleotide (“NMN” ndi “β-NMN”) ndi nucleotide yotengedwa ku ribose ndi nicotinamide.Niacinamide (nicotinamide,) ndi mtundu wa vitamini B3 (niacin.) Monga kalambulabwalo wa biochemical wa NAD +, ingakhale yothandiza popewa pellagra.
Mawonekedwe ake osakhazikika, niacin, amapezeka muzakudya zosiyanasiyana: Mtedza, Bowa (portobello, wokazinga), Avocados, Nandolo Zobiriwira (zatsopano), ndi nsomba zina ndi nyama zanyama.
M'kafukufuku [pa mbewa], NMN yawonetsa kusintha kusokonezeka kwa mitsempha yokhudzana ndi ukalamba pochepetsa kupsinjika kwa okosijeni.
Dzina: Beta-Nicotinamide Mononucleotide
CAS ＃: 1094-61-7
Dzina lazogulitsa: Beta-Nicotinamide Mononucleotide;NMN
Dzina lina:β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;Nicotinamide Ribotide;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide
CAS: 1094-61-7
Mapangidwe a maselo: C11H15N2O8P
Kulemera kwa Molecular: 334.22
Chiyero: 98%
Kutentha kosungira: 2-8°C
Maonekedwe: ufa woyera
Ntchito: anti-kukalamba
Ntchito:
1.Nicotinamide mononucleotide m'maselo aumunthu amagwira ntchito yofunika kwambiri pakupanga mphamvu, imaphatikizapo NAD intracellular (nicotinamide adenine dinucleotide, cell energy conversion yofunika coenzyme) synthesis, yomwe imagwiritsidwa ntchito poletsa kukalamba, kugwa kwa shuga wa magazi ndi mankhwala ena osamalira thanzi.
2. Nicotinamide Mononucleotide ndi mavitamini osungunuka m'madzi, Mankhwalawa ndi ufa woyera wa crystalline, wopanda fungo kapena pafupifupi wopanda fungo, wowawa mu kukoma, kusungunuka momasuka m'madzi kapena ethanol, kusungunuka mu glycerin.
3.Nicotinamide Mononucleotide ndi yosavuta kuyamwa pakamwa, ndipo imatha kugawidwa kwambiri m'thupi, ma metabolites owonjezera kapena ma prototype amachotsa msanga mkodzo.Nicotinamide ndi gawo la coenzyme I ndi coenzyme II, imagwira gawo la hydrogen yobereka mu biological oxidation kupuma unyolo, imatha kulimbikitsa njira zachilengedwe zamakutidwe ndi okosijeni komanso kagayidwe ka minofu, kukhalabe ndi minofu yabwino (makamaka khungu, m'mimba ndi dongosolo lamanjenje) kukhulupirika kuli ndi gawo lofunikira. .
Kuphatikiza apo, nicotinamide imakhala ndi kupewa komanso kuchiza matenda a mtima, ntchito ya sinus node komanso anti-fast experimental arrhythmias, nicotinamide imatha kusintha kwambiri kugunda kwa mtima komanso chipika cha atrioventricular choyambitsidwa ndi verapamil.
