Sialic Acid Poda

Sialic acid (SA), yomwe imadziwika kuti "N-acetylneuraminic acid," ndi chakudya chomwe chimapezeka mwachilengedwe.Poyamba anali olekanitsidwa ndi submandibular gland mucin, motero dzina lake.Sialic acid nthawi zambiri imakhala ngati oligosaccharides, glycolipids kapena glycoproteins.M'thupi la munthu, muubongo mumakhala sialic acid wambiri.Sialic acid yomwe ili mu imvi ndi nthawi 15 kuposa ya ziwalo zamkati monga chiwindi ndi mapapo.Chakudya chachikulu cha sialic acid ndi mkaka wa m'mawere, womwe umapezekanso mu mkaka, mazira ndi tchizi.

Muzamankhwala, ma glycolipids okhala ndi sialic acid amatchedwa gangliosides, omwe amagwira ntchito yofunika kwambiri pakupanga ndikukula kwa ubongo ndi dongosolo lamanjenje.Panthawi imodzimodziyo, maphunziro a zinyama awonetsa kuti kuchepa kwa magulu a ganglioside kumayenderana ndi kusowa kwa zakudya m'thupi komanso kuchepa kwa luso la kuphunzira, pamene kuwonjezera kwa sialic acid kungathandize kusintha khalidwe la maphunziro a nyama.Kupezeka kokwanira kwa sialic acid kungakhale kofunikira makamaka pakukula bwino kwa ubongo wa ana omwe ali ndi kulemera kochepa.Mwana akabadwa, asidi wa sialic mu mkaka wa m'mawere ndi wofunikira kuti akule bwino.Kafukufuku wasonyeza kuti sialic acid mwa amayi pambuyo pobereka amatsika pakapita nthawi.Choncho, kudya mosalekeza kwa sialic acid yokwanira pa nthawi ya mimba komanso pambuyo pa mimba kungathandize kuti sialic acid ikhalebe m'thupi.Kuphatikiza apo, zomwe zili mu sialic acid zimagwirizananso kwambiri ndi zomwe zili mu DHA, zomwe zikuwonetsa kuti zitha kukhala zogwirizana ndi kapangidwe kaubongo komanso kakulidwe ka ubongo mwa makanda, zonse zomwe zingakhale zopindulitsa pakukulitsa ubongo koyambirira.

Kafukufuku wasonyeza kuti nthawi ya golidi ya kukula kwa ubongo wa munthu ili pakati pa zaka 2 ndi 2 zakubadwa.Gawoli ndi nthawi yovuta kwambiri pakusinthitsa nambala ya ma cell aubongo, kuchuluka kwa voliyumu, kugwira ntchito bwino, komanso kupanga neural network.Chifukwa chake, amayi anzeru mwachibadwa amalabadira kudya kokwanira kwa sialic acid pa nthawi yapakati.Mwana akabadwa, mkaka wa m'mawere ndi njira yabwino yowonjezeramo sialic acid kwa mwana, chifukwa pafupifupi 0.3-1.5 mg wa sialic acid pa millilita ya mkaka wa m'mawere.M'malo mwake, nyama zonse zoyamwitsa, kuphatikiza anthu, zimatha kupanga sialic acid kuchokera pachiwindi paokha.Komabe, kukula kwa chiwindi kwa ana obadwa kumene sikunakhwime, ndipo kufunika kwa kukula mofulumira ndi kukula kwa ubongo kungachepetse kaphatikizidwe ka sialic acid, makamaka kwa ana obadwa msanga.Chifukwa chake, sialic acid mu mkaka wa m'mawere ndiyofunikira pakuwonetsetsa kuti mwana akule bwino.
Ofufuza a ku Australia apeza kuti makanda oyamwitsa amakhala ndi asidi wochuluka wa sialic mu cortex yakutsogolo kusiyana ndi makanda odyetsedwa mkaka.Izi zikhoza kulimbikitsa mapangidwe synapses, kuthandiza mwana kukumbukira kupanga khola structural maziko, ndi kulimbikitsa chitukuko cha mantha dongosolo.

Kodi Sialic acid ndi chiyani

Sialic Acidndi gulu la zotumphukira za neuraminic acid (N- kapena O-substituted zotumphukira neuraminic acid).Kawirikawiri mu mawonekedwe a oligosaccharides, glycolipids kapena glycoproteins.

Sialic Acidndi dzina la membala wodziwika bwino wa gululi - N-acetylneuraminic acid (Neu5Ac kapena NANA).

Sialic acid banja

Amadziwika ndi mamembala pafupifupi 50, onse ochokera ku 9-carbon sugar neuraminic acid.

N-acetylneuraminic acid (Neu5Ac), N-glycolneuraminic

asidi (Neu5Gc) ndi deaminoneuraminic acid (KDN) ndi core monomer yake.

N-acetylneuraminic acid ndi mtundu wokhawo wa Sialic Acid m'thupi lathu.

Sialic Acid ndi Chisa cha Mbalame

Chifukwa Sialic acid ili ndi chisa cha mbalame, imatchedwanso chisa cha mbalame, chomwe ndi chizindikiro chofunikira cha chisa cha mbalame.

Sialic Acid ndiye chakudya chachikulu chomwe chili mu chisa cha Mbalame, pafupifupi 3% -15% kulemera kwake.

Pazakudya zonse zomwe zimadziwika, chisa cha Mbalame chimakhala ndi asidi ambiri a Sialid, pafupifupi nthawi 50 kuposa zakudya zina.

1g Chisa cha Mbalame chimakhala ndi mazira 40 ngati titapeza mulingo wofanana wa Sialic Acid.

Zakudya za Sialic Acid

Nthawi zambiri, zomera mulibe Sialic acid.Sialic acid yomwe imatsogolera ku mkaka waumunthu, nyama, dzira, ndi tchizi.

Zomwe zili mu sialic acid yonse muzakudya wamba (µg/g kapena µg/ml).

Titha kuwona kuti sialic acid mu mkaka waumunthu ndi wokwera kwambiri, womwe ndi wofunikira kwambiri pakukula kwa ubongo wa mwana.

Koma za Sialic Acid ndizosiyana mu Nthawi zosiyanasiyana Mkaka wamunthu

Colostrum ya mkaka wa m'mawere 1300 +/- 322 mg/l

Patapita masiku 10 983 +/- 455 mg/l

Ufa wa mkaka wakhanda asanakwane 197 +/- 31 mg/l

Ma formula amkaka osinthidwa 190 +/- 31 mg/l

Mkaka wosinthidwa pang'ono 100 +/- 33 mg/l

Zotsatira zamkaka zamkaka 100 +/- 33 mg/l

Mkaka wopangidwa ndi soya 34 +/- 9 mg/l

Poyerekeza ndi mkaka wa m'mawere, ufa wa mkaka wakhanda uli ndi pafupifupi 20% Sialic acid kuchokera ku mkaka wa Anthu, pamene mwana amatha kupeza 25% Sialic acid kuchokera ku mkaka wa m'mawere.

Kwa mwana wosabadwa, sialic acid ndiyofunikira kwambiri kuposa mwana wathanzi pakukula kwa Ubongo.

Phunziro la Sialic Acid pa Mkaka wa ufa

"Zotsatira zake zidawonetsa kuti sialic acid yomwe ili muubongo imakhala ndi gawo lofunikira pakuzindikira khalidwe.Gulu lina lidawona kuphunzira kwabwino ndi chithandizo chaulere cha sialic acid mu makoswe. ”

Ndemanga za CAB: Mawonedwe mu Agriculture, Veterinary Science, Nutrition, and Natural

Zida 2006 1, No. 018, Kodi sialic acid mu mkaka chakudya ubongo?, Bing Wang

"Mapeto ake ndi kuchuluka kwa ubongo wa ganglioside ndi glycoprotein sialic acid mwa makanda omwe amadyetsedwa mkaka waumunthu akuwonetsa kuchuluka kwa synaptogenesis ndi kusiyana kwa neurodevelopment."

Am J Clin Nutr 2003; 78:1024-9.Zasindikizidwa ku USA.© 2003 American Society for Clinical Nutrition，Brain ganglioside, ndi glycoprotein sialic acid mu oyamwitsa poyerekeza ndi makanda odyetsedwa, Bing Wang

"Neural cell membranes imakhala ndi sialic acid yochulukirapo kuwirikiza ka 20 kuposa mitundu ina ya nembanemba, zomwe zikuwonetsa kuti sialic acid imakhala ndi gawo lowonekera pamapangidwe a minyewa."

The European Journal of Clinical Nutrition, (2003) 57, 1351-1369, Udindo ndi kuthekera kwa sialic acid muzakudya zaumunthu, Bing Wang.

Ntchito ya N-Acetylneuraminic acid

Mkaka Ufa

Pakali pano, ufa wa mkaka wa Amayi Oyamwitsa Wochulukirachulukira, Ufa Wamkaka wa Ana, ndi Zakudya zowonjezera zili ndi Sialic Acid Pamsika.

Kwa Amayi Oyamwitsa

Kwa Mwana Mkaka wa ufa 0-12 miyezi

Za Healthcare product

Za Chakumwa

Popeza kuti asidi wa Sialic ali ndi mphamvu yabwino yosungunuka m'madzi, makampani ambiri akuyesera kupanga zakumwa za Sialic acid za thanzi la Ubongo kapena kuwonjezera mu mkaka.

Chitetezo cha N-Acetylneuraminic

N-Acetylneuraminic acid ndi otetezeka kwambiri.Pakadali pano, palibe nkhani zoyipa zomwe zanenedwa pa Sialic acid.

Maboma a USA, China, ndi EU amavomereza kuti Sialic acid igwiritsidwe ntchito muzakudya ndi Zaumoyo.

USA

Mu 2015, N-Acetyl-D-neuraminic acid (Sialic acid) idatsimikiziridwa Kuti Ndi Yotetezeka Kwambiri (GRAS)

China

Mu 2017, Boma la China lidavomereza N-Acetylneuraminic acid ngati Chatsopano Chakudya Chakudya.

EU

Chitetezo cha synthetic N-acetyl-d-neuraminic acid monga chakudya chodziwika bwino pansi pa Malamulo (EC) No 258/97

Pa 16 October 2015, dzina la ana amasiye (EU/3/12/972) linaperekedwa ndi European Commission ku Ultragenyx UK Limited, United Kingdom, kaamba ka sialic acid (yomwe imadziwikanso kuti aceneuramic acid) pochiza GNE myopathy.

Lingaliro la Sayansi pa kutsimikizika kwa zonena zaumoyo zokhudzana ndi sialic acid ndi kuphunzira ndi kukumbukira (ID 1594) motsatira Article 13(1) of Regulation (EC) No 1924/2006

Mlingo

CFDA imalimbikitsa 500 mg / tsiku

Chakudya chatsopano chikuwonetsa 55mg/tsiku kwa Ana ndi 220mg/tsiku kwa Achichepere ndi azaka zapakati.

N-acetylneuraminic acid ntchito

Kusintha kwa Memory ndi Intelligence

Polumikizana ndi nembanemba zama cell aubongo ndi ma synapses, sialic acid imawonjezera kuyankha kwa ma synapses m'maselo a minyewa yaubongo, potero kulimbikitsa kukula kwa kukumbukira ndi luntha.

Asayansi aku New Zealand achita zoyeserera zingapo kuti atsimikizire mbali yofunika kwambiri ya asidi wa mbalame pakukula kwa luntha la ana.Pomaliza, ofufuzawo adatsimikiza kuti kuphatikizira ma asidi a mbalame mwa makanda kumatha kuwonjezera kuchuluka kwa asidi wa mbalame muubongo, potero kumapangitsa kuti ubongo uzitha kuphunzira.

Kupititsa patsogolo mphamvu ya m'matumbo kuyamwa

Malinga ndi losavuta thupi chodabwitsa cha amuna kapena akazi, ndi zabwino mlandu mchere ndi mavitamini ena kulowa m`matumbo mosavuta pamodzi ndi amphamvu zoipa mlandu mbalame chisa asidi, kotero m`mimba mayamwidwe mavitamini ndi mchere.Kukhoza kwawonjezedwa kuchokera pamenepo.

Limbikitsani matumbo antibacterial detoxification

Sialic Acid pa mapuloteni a cell membrane amatenga gawo lofunikira pakuwongolera kuzindikira kwa ma cell, kutulutsa poizoni wa kolera, kupewa matenda a Escherichia coli, komanso kuwongolera mapuloteni amagazi theka la moyo.

Moyo wautali

Sialic acid imakhala ndi chitetezo komanso kukhazikika pama cell, ndipo kusowa kwa sialic acid kungayambitse kuchepa kwa moyo wa maselo a magazi komanso kuchepa kwa glycoprotein metabolism.

Pangani mankhwala atsopano a Sialic Acid

Asayansi amayesa kuchiza matenda am'mimba ndi sialic acid anti-adhesion drugs.Sialic acid odana ndi zomatira mankhwala amatha kuchiza Helicobacter pylori kuchiza zilonda zam'mimba ndi zilonda zam'mimba.

Sialic acid ndi glycoprotein.Imatsimikizira kuzindikira ndi kumangidwa kwa maselo ndipo imakhala ndi zotsatira zofanana zotsutsana ndi kutupa monga aspirin.

Sialic acid ndi mankhwala apakati kapena apakhungu minyewa matenda ndi demyelinating matenda;asidi sialic ndi expectorant chifuwa.

Sialic acid monga zopangira zimatha kupanga mankhwala ofunikira a shuga, odana ndi ma virus, odana ndi chotupa, odana ndi kutupa, komanso kuchiza matenda a dementia ali ndi zotsatira zabwino kwambiri.

Njira yopangira Sialic Acid

Zopangira zoyambira ndi glucose, mowa wa chimanga, glycerinum, ndi magnesium sulfate.Ndipo timagwiritsa ntchito ukadaulo wofufumitsa.Panthawiyi, timagwiritsa ntchito njira yotsekera kuti zinthu zikhale zaukhondo.Kenako ndi hydrolysis, ndende, kuyanika, ndi kuswa.Pambuyo pa njira zonse, timapeza chomaliza.Ndipo QC yathu idzagwiritsa ntchito HPLC kuyesa mtundu wazinthu pagulu lililonse tisanapereke kwa makasitomala.

Product Name: Sialic acid ;N-Acetylneuraminic acid

Dzina Lina: 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic asidi o-Sialic asidi Galactononulosonic asidi Lactamine asidi NANA N-Acetylsialic asidi

Poyambira: Chisa cha mbalame zodyedwa
Chiwerengero: 20-98%
Maonekedwe: ufa woyera woyera
CAS NO.: 131-48-6
MW: 309.27
Chithunzi cha C11H19NO9

Malo Ochokera: China

Kusungirako: Sungani pamalo ozizira ndi owuma, khalani kutali ndi kuwala kwachindunji ndi kutentha.
Kukhazikika: Zaka ziwiri ngati zasungidwa bwino.

NTCHITO:

1. Anti-virus ntchito.
2. Ntchito yolimbana ndi khansa.
3. Anti-kutupa ntchito.
4. Ntchito yoteteza ku matenda a bacteriological.
5. Kulamulira mphamvu ya chitetezo cha mthupi.
6. Kuletsa kutulutsa mtundu.
7. Kusintha kwa chizindikiro m'maselo a mitsempha.
8. Kuchita mbali yofunika kwambiri pakukula kwa ubongo ndi kuphunzira.
9. Monga kalambulabwalo wa kupanga mankhwala ambiri amankhwala.