soosaaray peony cad

Magaca Alaabta:Soosaarka Peony Cadbudo

Magac kale:Budada Cad ee Shiinaha oo soo saarta budada

Isha dhirta:Radix Paeoniae Alba

Waxyaabaha ay ka kooban:Wadarta glucosides ee Paeonia (TGP):Paeoniflorin, Oxypaeoniflorin, Albiflorin, Benzoylpaeoniflorin

Tilmaamaha:Paeoniflorin10% ~ 40% (HPLC), 1.5%Albasides, 80%Glycosides

Lambarka CAS:23180-57-6

Midabka: Jaalle-brownbudooo leh ur sifada iyo dhadhanka

GMOXaalada:GMO Bilaash

Xirmooyinka: 25kgs durbaannada fiber-ka

Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan

Life Life:24 bilood laga bilaabo taariikhda wax soo saarka

Soosaarka Peony Cadwaxaa loola jeedaa ka soo saarida maaddooyinka firfircoon ee peony cad iyada oo loo marayo habab saynis ah iyadoo loo eegayo tignoolajiyada gaarka ah.Sida laga soo xigtay falanqaynta culimada, maaddooyinka firfircoon ee laga soosaaray peony cad ee jidhka bini'aadamka waa sida soo socota.Afar ka mid ah kuwa ugu muhiimsan waa Paeoniflorin, Oxypaeoniflorin, Albiflorin, iyo Benzoylpaeoniflorin.

Soosaaray peony cad ayaa laga soosaaray xididka qallalan ee Paeonia lactiflora Pall., Geedka qoyska Ranunculaceae.Qaybteeda ugu muhiimsan waa paeoniflorin, taas oo si ballaaran loo isticmaali karo ma aha oo kaliya goobta caafimaadka laakiin sidoo kale warshadaha qurxinta.Soosaaray peony cad ayaa aad waxtar u leh wax qabadyada PDE4.Iyadoo la xakameynayo dhaqdhaqaaqa PDE4, waxay ka dhigi kartaa cAMP ee unugyada kala duwan ee bararka iyo difaaca jirka (sida neutrophils, macrophages, T lymphocytes iyo eosinophils, iwm.) waxay gaaraan feejignaan ku filan si ay u joojiyaan firfircoonida unugyada bararka waxayna sameeyaan saameyn anti-bararka.Waxa kale oo ay leedahay xanuunka xanuunka, antispasmodic, anti-boog, vasodilator, korodhka socodka dhiigga xubnaha, bakteeriyada, ilaalinta beerka, sunta, anti-mutagenic, iyo saamaynta anti-buro.

1,2,3,6-tetragalloyl gulukoos, 1,2,3,4,6-pentagalloyl glucose iyo gulukooska hexagalloyl ee u dhigma iyo gulukooska heptagalloyl ayaa laga soocay tannin ee xididka peony cad.Waxa kale oo ku jira catechin dextrorotatory iyo saliid kacsan.Saliida kacsan waxay inta badan ka kooban tahay benzoic acid, peony phenol iyo aalkolo iyo phenols kale.1. Paeoniflorin: caanaha molecular C23H28O11, miisaanka kelli 480.45.Hygroscopic amorphous budada, [α] D16-12.8 ° (C=4.6, methanol), tetraacetate waa kiristaalo irbad aan midab lahayn, mp.196℃.2. Paeonol: Ereyada la midka ah waa paeonol, alkohol peony, paeonal, iyo peonol.Qaaciddada molecular C9H10O3, miisaanka kelli 166.7.Kiristaalo irbad qaabaysan oo aan midab lahayn (ethanol), mp.50℃, in yar oo biyaha ku milmay, waxay ku milmi karaan uumiga biyaha, ku milma ethanol, ether, acetone, chloroform, benzene iyo carbon disulfide.3. Kuwo kale: Waxaa ku jira qadar yar oo ah oxypaeoniflorin, albiforin, benzoylpaeoniflorin, lactiflorin, paeoniflorigenone monoterpene cusub oo leh saameyn neuromuscular ah oo ku saabsan jiirarka, 1,2,3,4,6-Pentagalloylglucose oo leh saameyn fayruska ah, gallotannin, d- acid, ethyl gallate, tannin, β-sitosterol, sonkor, istaarij, xab, iwm.

Hawlaha:

1. Anti-bararka, bakteeriyada iyo saamaynta fayraska.Soosaarida cad ee peony waxay saameyn weyn ku leedahay ukunta bararka bararka bararka ee jiirka waxayna joojisaa faafinta granuloma kubbadda suufka.Wadarta glycosides ee paeony waxay leeyihiin ka-hortagga bararka iyo saamaynta immunomodulatory-ku-tiirsanaanta jirka ee jiirka qaba xanuunka lafaha.Diyaargarowga peony cad wuxuu leeyahay saameyno xaddidan oo gaar ah oo ku saabsan Staphylococcus aureus, hemolytic Streptococcus, pneumococcus, Shigella dysenteriae, Typhoid bacillus, Vibrio cholerae, Escherichia coli iyo Pseudomonas aeruginosa.Intaa waxaa dheer, 1:40 decoction peony waxay joojin kartaa fayraska Jingke 68-1 iyo fayraska herpes.
2. Saamaynta hepatoprotective.Soosaarka cad ee peony wuxuu leeyahay saameyn weyn oo liddi ku ah dhaawaca beerka iyo kororka SGPT ee ay keento D-galactosamine.Waxay yarayn kartaa SGPT waxayna dib u soo celin kartaa nabarrada unugyada beerka iyo necrosis si caadi ah.Soosaarka ethanol ee xididka cad ee peony wuxuu yarayn karaa kororka wadarta guud ee dhaqdhaqaaqa lactate dehydrogenase iyo isoenzymes ee jiirka ee qaba dhaawaca beerka ba'an ee ay keento aflatoxin.Wadarta glycosides ee paeony waxay joojin kartaa kororka SGPT iyo lactate dehydrogenase ee jiirarka ay sababto kaarboon tetrachloride, waxayna saameyn liddi ku ah ku yeelan karaan xumaanshaha eosinophilic iyo necrosis unugyada beerka.
3. Saamaynta Antioxidant: Soosaarida xididka peony ee cad TGP waxay leedahay antioxidant iyo saamaynta xasilinta xuubka unugyada, waxaana laga yaabaa inay saameyn xoqdo ku yeelato xagjirrada xorta ah.
4. Saamaynta habka wadnaha iyo xididdada cad ee peony waxay ballaarin kartaa xididdada dhiigga halbowlayaasha wadnaha ee go'doonsan, waxay iska caabiyaan ischemia ba'an ee myocardial ischemia ee jiirka ee uu keeno pituitaryin, waxayna hoos u dhigtaa caabbinta xididdada durugsan waxayna kordhisaa socodka dhiigga marka lagu duro halbowlaha.Paeoniflorin sidoo kale waxay saameyn ballaaran ku leedahay xididdada dhiigga halbowlaha ah iyo xididdada dhiigga ee durugsan, waxayna sababtaa hoos u dhaca cadaadiska dhiigga.Daraasaduhu waxay muujiyeen in paeoniflorin, oo laga soosaaray xidid peony cad, uu saameyn xannibaad ah ku leeyahay isku-darka platelet-ka ee ADP ee jiirka ku jira vitro.
5. Saamaynta dheef-shiid kiimikaadka soosaarka cad ee peony wuxuu leeyahay saameyn xannibaad ah oo ku yimaada foosha degdega ah ee xiidmaha hyperexcitability iyo foosha ay keento barium chloride, laakiin wax saameyn ah kuma laha foosha ay keento acetylcholine.Isku dhafka biyaha laga soo saaray ee licorice iyo xidid peony cad (0.21g) waxay saameyn weyn ku leedahay dhaqdhaqaaqa muruqyada siman ee xiidmaha ee bakaylaha gudaha vivo.Saamaynta isku dhafan ee labadooduba way ka fiican yihiin kuwa keligood ah, iyo saamaynta yaraynta soo noqnoqda ayaa ka xoog badan saamaynta yaraynta baaxadda.Hoos u dhigista inta jeer ee foosha xiidmaha bakayle 20 ilaa 25 daqiiqo ka dib maamulka ayaa ahaa 64.71% iyo 70.59% ee kooxda kantaroolka caadiga ah, siday u kala horreeyaan, wayna ka xoog badnayd tan atropine (0.25 mg) ee kooxda xakamaynta togan.Paeoniflorin waxay leedahay saameyn xannibaado ah tuubooyinka mindhicirka ee go'doonsan iyo dhaqdhaqaaqa caloosha ee doofaarka guinea iyo jiirka, iyo sidoo kale muruqa siman ee jiirka ilmo-galeenka, waxayna ka soo horjeedaan foosha ay keento oxytocin.Waxay leedahay saamayn is-dhexgal ah oo leh Kiimikada buug-gacmeedka khamriga FM100 ee licorice-ka.Paeoniflorin ayaa saameyn weyn oo ka hortag ah ku leh boogaha caloosha iyo mindhicirka ee jiirka oo ay sababeen kicinta walaaca leh.
6. Saamaynta dejineed, xanuunka xanuunka iyo ka hortagga.Cirbadda cad ee peony iyo paeoniflorin labaduba waxay leeyihiin saameyn dejineed iyo xanuunka.Ku duridda qadar yar oo paeoniflorin ah oo la geliyo marinnada maskaxda ee xayawaanka waxay keeni kartaa xaalad hurdo oo cad.Cirbadda intraperitoneal ee 1g/kg ee paeoniflorin oo laga soosaaray xididka cad ee peony ee jiirarka waxay yarayn kartaa dhaqdhaqaaqyada iskood ee xayawaanka, waxay dheeraysaa wakhtiga hurdada ee pentobarbital, waxay joojisaa falcelinta jiirarka ee ay keento cirbadeynta intraperitoneal ee acetic acid, waxayna iska caabin kartaa pentylenettrazole.Gariir uu sababay.Wadarta glycosides ee paeony waxay leeyihiin saameyn xanuun oo muhiim ah waxayna wanaajin karaan saameynta xanuunka morphine iyo clonidine.Naloxone ma saameynayso saameynta xanuunka ee wadarta glycosides ee paeony, taasoo soo jeedinaysa in mabda'a xanuunka ma aha in la kiciyo soo-qabayaasha opioid.Soosaarka Peony wuxuu joojin karaa gariir uu keeno strychnine.Paeoniflorin wax saameyn ah kuma laha muruqa lafaha ee go'doonsan, sidaas darteed waxaa la qiyaasaa in saameynteeda anticonvulsant ay udub dhexaad u tahay.
7. Saamaynta nidaamka dhiiga: Soosaarida alkolada Paeony waxay joojin kartaa isu geynta platelet ee bakaylaha ay keentay ADP, collagen, iyo arachidonic acid in vitro.
8. Saamaynta nidaamka difaaca.Xididka cad ee peony wuxuu kor u qaadi karaa soo saarida unugyada difaaca jirka ee beeryarada wuxuuna si gaar ah u wanaajin karaa jawaab celinta jiirarka ee unugyada dhiigga cas ee idaha.Decoction-ka cad ee peony wuxuu ka soo horjeedaa saameynta xannibaadda ee cyclophosphamide ee dhiigga durugsan ee T lymphocytes ee jiirarka, dib ugu soo celisa heerarkii caadiga ahaa, waxayna dib u soo celisaa shaqada difaaca unugyada hoose ee caadiga ah.Wadarta glycosides ee paeony waxay kor u qaadi kartaa kororka lymphocytes splenic ee jiirarka ay keentay concanavalin, waxay kor u qaaddaa wax soo saarka α-interferon ee leukocytes dhiigga xudunta aadanaha ee uu keeno fayraska cudurka daacuunka ee Newcastle, waxayna saameyn laba jiho ah ku yeelan kartaa soosaarka interleukin-2 ee jiirka. splenocytes oo ay keentay concanavalin.saamaynta habaynta.
9. Saamaynta Xoojinta: Soosaarida alkolada peony ee cad waxay dheerayn kartaa wakhtiga dabaasha ee jiirarka iyo wakhtiga badbaadada hypoxic ee jiirarka, waxayna leedahay saamayn xoojinaysa.
10. Saamaynta anti-mutagenic iyo anti-buro Soosaarida cad ee peony waxay faragelin kartaa dhaqdhaqaaqa enzyme ee isku dhafka S9, waxayna joojin kartaa dheef-shiid kiimikaadka benzopyrene waxayna joojin kartaa saameynteeda mutagenic.

11. Saamaynta kale (1) Saamaynta Antipyretic: Paeoniflorin waxay saamayn antipyretic ah ku leedahay jiirarka leh qandho macmal ah waxayna yarayn kartaa heerkulka jidhka caadiga ah ee jiirarka.(2) Saamaynta kobcinta xusuusta: Wadarta glycosides ee paeony waxay wanaajin kartaa barashada liidata iyo helitaanka xusuusta ee jiirarka ee ay keento scopolamine.(3) Saamaynta anti-hypoxic: Wadarta glycosides ee paeony cad waxay sii dheerayn kartaa wakhtiga badbaadada jiirarka ee cadaadiska caadiga ah iyo hypoxia, waxay yareeyaan isticmaalka guud ee ogsijiinta jiirarka, waxayna yareeyaan dhimashada jiirarka sababtoo ah sunta potassium cyanide iyo hypoxia.