Lebitso la Sehlahisoa:Agomelatine

Lebitso le Leng:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

Nomoro ea CAS:138112-76-2

Litlhaloso: 99.0%

'Mala: Phofo e tšoeu e nang le monko le tatso e ikhethang

Boemo ba GMO:GMO Mahala

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

Agomelatineke mofuta o mocha oa antidepressant. Mokhoa oa eona oa ts'ebetso o phunyeha ka mokhoa o tloaelehileng oa monoamine transmitter system.Agomelatine ke melatoninergic agonist le mohanyetsi ea khethiloeng oa li-receptor tsa 5-HT2C, 'me e bontšitsoe hore e sebetsa ka mafolofolo liphoofolong tse ngata tsa ho tepella maikutlong. Agomelatine (S20098) e bonts'itse litekanyetso tsa pKi tsa 6.4 le 6.2 ho li-receptor tsa tlhaho (porcine) le tse entsoeng ka batho (h) 5-hydroxytryptamine (5-HT)2C receptors, ka ho latellana.

Agomelatine ke mofuta o le mong oa phofo e tšoeu kapa e tšoeu ea kristale kapa e tiileng e tšoeu. Lebitso la IUPAC la k'hemik'hale ena ke N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. K'hemik'hale ena ke ea Aromatics Compounds;Aromatics;Neurochemicals;APIS. E lokela ho bolokoa ho -20°C Freezer.

 
Joaloka Meriana ea Pharmaceutical Intermediates, Agomelatine e sebelisoa ho phekola bothata bo boholo ba ho tepella maikutlong, khatello ea maikutlo. Agomelatine e sebelisoa ho phekola bothata bo boholo ba ho tepella maikutlong, khatello ea maikutlo. Ntho ea lithethefatsi bakeng sa tsamaiso ea methapo. Antidepressant, anxiolytic, lokisa morethetho oa ho robala le ho laola nako ea likokoana-hloko. Agomelatine ke agonist ea melatoninergic le mohanyetsi ea khethang oa li-receptor tsa 5-ht2c. Agomelatine ke moriana o thibelang ho tepella maikutlo. E khetholloa e le norepinephrine-dopamine disinhibitor (NDDI) ka lebaka la bohanyetsi ba eona ba 5-HT2C receptor. Agomelatine hape ke agonist e matla ho li-receptor tsa melatonin e etsang hore e be moriana oa pele oa melatonergic antidepressant.

.Agomelatine e amana haufi-ufi le melatonin. Agomelatine ke agonist e matla ho li-receptor tsa melatonin le mohanyetsi ho li-receptor tsa serotonin-2C (5-HT2C), tse lekiloeng ka mokhoa oa phoofolo oa ho tepella maikutlong.

Agomelatine ke antidepressant e sebelisoang ho phekola ho tepella maikutlong.

Hangata boko bo khona ho etsa bonnete ba hore re na le lik'hemik'hale tse lekaneng tseo re li hlokang hore re sebetse hantle. Empa ho tepella maikutlo ho ka ama lik’hemik’hale tse ngata tsa boko.

Lik'hemik'hale tsena li kenyelletsa noradrenaline, dopamine le serotonin; khatello ea maikutlo e fokotsa maemo a li-transmitter tsena tsa boko. Ho tepella maikutlo ho boetse ho ama k'hemik'hale e bitsoang melatonin. Ho fokotseha ha melatonin ho amahanngoa le tšitiso ea mekhoa ea rona ea ho robala.

Agomelatine ke antidepressant ea pele ho eketsa tšebetso ea melatonin ka kotloloho. E etsa sena ka ho sebetsa joalo ka melatonin libakeng tseo melatonin e sebetsang ho tsona. (Tsena li tsejoa e le melatonin receptors). Ka ho eketsa ts'ebetso ea melatonin, agomelatine e eketsa ka kotloloho ts'ebetso ea noradrenaline le dopamine.

Agomelatine e qalile ho thakholoa Europe ka 2009 'me joale e amohetsoe ho sebelisoa linaheng tse fetang 70. Ho fapana le li-antidepressants tsa setso, agomelatine e sebetsa ka ho lebisa melatonin le li-receptor tsa serotonin bokong. Ka ho sebetsa joalo ka agonist ho li-receptor tsa melatonin, agomelatine e thusa ho tloaetsa mekhoa ea boroko e sitisang hangata e amanang le khatello ea maikutlo. Mokhoa ona ha o thuse feela ho ntlafatsa boleng ba boroko empa hape o thusa ho khutlisetsa morethetho oa tlhaho oa circadian. Ho feta moo, agomelatine e sebetsa e le mohanyetsi ho li-receptor tse itseng tsa serotonin (5-HT2C receptors). Ketso ena e ikhethang e habeli ka tsela e sa tobang e ntlafatsa boteng ba serotonin bokong, neurotransmitter e ikarabellang bakeng sa ho laola maikutlo. Ka ho laola maemo a serotonin, agomelatine e ka sebetsa e le sethethefatsi se atlehang sa ho tepella maikutlo, se imollang matšoao a kang ho hlonama, ho lahleheloa ke thahasello, maikutlo a molato kapa ho hloka thuso. Ho feta moo, agomelatine e ka fana ka melemo e meng. Patlisiso e fana ka maikutlo a hore e ka thusa ho ntlafatsa ts'ebetso ea kelello Patlisiso e bonts'a bokhoni ba eona ba ho ntlafatsa mohopolo, tlhokomelo, le ts'ebetso ea tsamaiso, e e etsa sebaka se thabisang sa lipatlisiso tsa kamoso.

Mosebetsi:

Agomelatine e ka thusa ho laola 'body clock' ea hau (circadian rhythm) e nang le melemo ea maikutlo le ho tepella maikutlong ha boroko Agomelatine e sebelisoa ho phekola khatello ea maikutlo kapa ho thusa ho thibela ho tepella maikutlong ho khutla, 'me e fumaneha feela ka lengolo la ngaka. Matšoao a ho tepella maikutlong a fapana ho ea ka motho a le mong, empa hangata a akarelletsa ho hlonama ho sa khaotseng, ho lahleheloa ke thahasello mesebetsing eo u e ratang haholo, ho ikutloa u se na thuso, mathata a ho robala, ho ikutloa u fokotsehile, ho tšoenyeha kapa ho fetoha ha takatso ea lijo le boima ba ’mele. Liphetoho borokong ba hao ba letsatsi le letsatsi le takatso ea lijo ke mehlala ea litšitiso tsa lioache tsa 'mele oa hau tse etsahalang hangata ho tepella maikutlong.