isicatshulwa se-peony emhlophe

Igama lemveliso:White Peony Extractumgubo

Elinye Igama:I-Chinese White Blossom Extract Powder

Umthombo wezityalo:Radix Paeoniae Alba

Izithako:Iyonke iiglucosides zePaeonia (TGP):I-Paeoniflorin, Oxypaeoniflorin, Albiflorin, Benzoylpaeoniflorin

Iinkcukacha:I-Paeoniflorin10% ~40% (HPLC), 1.5%Albasides, 80%Glycosides

Inombolo yeCAS:23180-57-6

Umbala: Mthubi-mdakaumguboenevumba elibonakalayo kunye nencasa

GMOIsimo:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

White Peony Extractibhekisa ekutsalweni kwezithako ezisebenzayo kwipeony emhlophe ngeendlela zenzululwazi ngokwetekhnoloji eyodwa.Ngokohlalutyo lwabaphengululi, izithako ezisebenzayo zesicatshulwa se-peony emhlophe kumzimba womntu zimi ngolu hlobo lweTshati.Ezine zezona zibalulekileyo yiPaeoniflorin, Oxypaeoniflorin, Albiflorin, kunye neBenzoylpaeoniflorin.

Isicatshulwa se-peony esimhlophe sikhutshwe kwingcambu eyomileyo ye-Paeonia lactiflora Pall., Isityalo sentsapho yaseRanunculaceae.Inxalenye yayo ephambili yi-paeoniflorin, engasetyenziswa ngokubanzi kungekuphela nje kwicandelo lezonyango kodwa nakwishishini lezithambiso.Isicatshulwa se-peony esimhlophe sisebenza kakhulu kwi-PDE4 inhibitor yomsebenzi.Ngokuthintela umsebenzi we-PDE4, unokwenza i-camp yeeseli ezahlukeneyo ezivuthayo kunye ne-immune (ezifana ne-neutrophils, i-macrophages, i-T lymphocytes kunye ne-eosinophils, njl.) zifikelele ekugxininiseni okwaneleyo ukuvimbela ukusebenza kweeseli ezivuthayo kwaye zenze i-anti-inflammatory effect.Kwakhona ine-analgesic, i-antispasmodic, i-anti-ulcer, i-vasodilator, i-organ flow flow flow, i-antibacterial, ukukhusela isibindi, i-detoxifying, i-anti-mutagenic, kunye ne-anti-tumor effects.

I-glucose ye-1,2,3,6-tetragalloyl, i-1,2,3,4,6-pentagalloyl i-glucose kunye ne-hexagalloyl i-glucose ehambelanayo kunye ne-heptagalloyl i-glucose yahlukaniswa kwi-tannin yengcambu ye-peony emhlophe.Kwakhona iqulethe i-catechin ye-dextrorotatory kunye neoli eguqukayo.Ioli eguquguqukayo iqulethe i-benzoic acid, i-peony phenol kunye nezinye i-alcohols kunye ne-phenols.1. I-Paeoniflorin: i-molecular formula C23H28O11, ubunzima be-molecular 480.45.I-Hygroscopic amorphous powder, [α]D16-12.8 ° (C = 4.6, methanol), i-tetraacetate i-crystals inaliti engenambala, mp.196℃.2. I-Paeonol: Izithethantonye yi-paeonol, i-peony alcohol, i-paeonal, kunye ne-peonol.I-molecular formula C9H10O3, ubunzima bemolekyuli 166.7.Iikristale ezingenambala ezimile okwenaliti (ethanol), mp.50℃, zinyibilika kancinane emanzini, zinokutshintshatshintsha ngomphunga wamanzi, zinyibilika kwi-ethanol, i-ether, i-acetone, i-chloroform, ibenzene kunye ne-carbon disulfide.3. Abanye: Iqulethe i-oxypaeoniflorin encinci, i-albiforin, i-benzoylpaeoniflorin, i-lactiflorin, i-monoterpene entsha ye-paeoniflorigenone ene-neuromuscular blocking effect kwiigundane, i-1,2,3,4,6-Pentagalloylglucose ene-antiviral effect, i-gallotannin, i-gal-lic acid. iasidi, i-ethyl gallate, i-tannin, i-β-sitosterol, iswekile, isitashi, i-mucus, njl.

Imisebenzi:

1. I-anti-inflammatory, antibacterial kunye ne-antiviral effects.Isicatshulwa se-peony esimhlophe sinempembelelo ebalulekileyo yokuthintela kwiqanda elimhlophe elibukhali elivuthayo kwi-edema kwiigundane kwaye linqanda ukwanda kwe-cotton ball granuloma.Iyonke i-glycosides ye-paeony ine-anti-inflammatory kunye ne-immune-dependent immunomodulatory effects kwiigundane ezine-adjuvant arthritis.Amalungiselelo e-peony amhlophe aneempembelelo ezithile zokuthintela kwi-Staphylococcus aureus, i-hemolytic Streptococcus, i-pneumococcus, i-Shigella dysenteriae, i-typhoid bacillus, i-Vibrio cholerae, i-Escherichia coli kunye ne-Pseudomonas aeruginosa.Ukongeza, i-1:40 i-peony decoction inokuthintela i-Jingke 68-1 intsholongwane kunye ne-herpes virus.
2. Isiphumo seHepatoprotective.Isicatshulwa se-peony esimhlophe sinempembelelo enkulu echasayo kumonakalo wesibindi kunye nokunyuka kwe-SGPT okubangelwa yi-D-galactosamine.Inokunciphisa i-SGPT kwaye ibuyisele izilonda zeeseli zesibindi kunye necrosis eqhelekileyo.I-ethanol extract ye-white peony root inokunciphisa ukwanda komsebenzi opheleleyo we-lactate dehydrogenase kunye ne-isoenzymes kwiigundane ezinokulimala kwesibindi esibuhlungu esibangelwa yi-aflatoxin.I-glycosides epheleleyo ye-paeony inokuthintela ukwanda kwe-SGPT kunye ne-lactate dehydrogenase kwiigundane ezibangelwa yi-carbon tetrachloride, kwaye ibe nefuthe elichasayo kwi-eosinophilic degeneration kunye ne-necrosis yezicubu zesibindi.
3. Isiphumo se-Antioxidant: Isicatshulwa sengcambu ye-peony emhlophe i-TGP ine-antioxidant kunye ne-membrane yeseli ezinzisayo, kwaye ingaba nefuthe lokukhupha kwi-radicals yamahhala.
4. Iziphumo zenkqubo ye-cardiovascular system Isicatshulwa se-peony emhlophe inokwandisa imithambo yegazi yentliziyo esecaleni, ukumelana ne-acute myocardial ischemia kwiigundane ezibangelwa yi-pituitaryin, kunye nokunciphisa ukuxhathisa kwe-peripheral vascular kunye nokwandisa ukuhamba kwegazi xa kufakwe kwi-artery.I-Paeoniflorin nayo inefuthe lokuhlanjululwa kwimithambo yegazi ye-coronary kunye ne-peripheral blood, kwaye ibangela ukuhla koxinzelelo lwegazi.Uphononongo lubonise ukuba i-paeoniflorin, isicatshulwa sengcambu ye-peony emhlophe, inempembelelo yokuthintela kwi-ADP-induced platelet aggregation kwi-rats in vitro.
5. Imiphumo yesisu sesisu Isicatshulwa se-peony esimhlophe sinempembelelo yokuthintela kwi-contraction ngokuzenzekelayo ye-intestinal hyperexcitability kunye ne-contraction ebangelwa yi-barium chloride, kodwa ayinayo impembelelo kwi-contraction ebangelwa yi-acetylcholine.Umxube okhutshwe ngamanzi we-licorice kunye nengcambu ye-peony emhlophe (0.21g) inempembelelo ebalulekileyo yokuthintela ukuhamba kwamathumbu e-intestinal smooth muscle kwimivundla kwi-vivo.Isiphumo esidityanisiweyo sesibini singcono kuneso sisodwa, kwaye isiphumo sokunciphisa i-frequency sinamandla kunesiphumo sokunciphisa i-amplitude.Ukunciphisa umvundla we-intestinal contraction frequency 20 ukuya kwi-25 imizuzu emva kokulawulwa kwaba yi-64.71% kunye ne-70.59% yaloo nto kwiqela eliqhelekileyo lokulawula, ngokulandelanayo, kwaye yayinamandla kune-atropine (0.25 mg) kwiqela lolawulo oluhle.I-Paeoniflorin ineempembelelo ezithintelayo kwiityhubhu zamathumbu ezizimeleyo kunye ne-vivo gastric motility kwi-Guinea pigs kunye neempuku, kunye ne-pute ye-uterine muscle egudileyo, kwaye inokuchasa ukucutha okubangelwa yi-oxytocin.Inomphumela we-synergistic kunye ne-Chemicalbook alcohol extract FM100 ye-licorice.I-Paeoniflorin inempembelelo enkulu yokuthintela kwizilonda zesisu kwiigundane ezibangelwa yi-stimuli yoxinzelelo.
6. I-sedative, i-analgesic, kunye nemiphumo ye-anticonvulsant.Inaliti emhlophe yepeony kunye ne-paeoniflorin zombini zineempembelelo zokuthoba kunye ne-analgesic.Ukutofwa isixa esincinci se-paeoniflorin kwi-ventricles yobuchopho bezilwanyana kunokubangela ukuba umntu alale.Inaliti ye-Intraperitoneal ye-1g/kg ye-paeoniflorin evela kwingcambu ye-peony emhlophe kwisicatshulwa kwiimpuku inokunciphisa imisebenzi ezenzekelayo yezilwanyana, yandise ixesha lokulala le-pentobarbital, ithintele ukusabela kokujijitheka kweempuku okubangelwa inaliti ye-intraperitoneal ye-acetic acid, kwaye ixhathise i-pentylenetetrazole.Ukuxhuzula okubangelwa.Iyonke i-glycosides ye-paeony ineempembelelo ezibalulekileyo ze-analgesic kwaye inokuphucula iziphumo ze-analgesic ze-morphine kunye ne-clonidine.I-Naloxone ayichaphazeli umphumo we-analgesic we-glycosides iyonke ye-paeony, ebonisa ukuba umgaqo wayo we-analgesic awuyi kuvuselela i-opioid receptors.Isicatshulwa se-peony sinokunqanda ukuxhuzula okubangelwa yi-strychnine.I-Paeoniflorin ayinayo impembelelo kwi-muscle ye-skeletal eyedwa, ngoko kuchazwa ukuba i-anticonvulsant effect yayo iphakathi.
7. Impembelelo kwinkqubo yegazi: I-Paeony alcohol extract inokuthintela ukuhlanganiswa kweplatelet kwimivundla eyenziwa yi-ADP, i-collagen, kunye ne-arachidonic acid in vitro.
8. Impembelelo kwi-immune system.Ingcambu ye-peony emhlophe inokukhuthaza ukuveliswa kwezithinteli-gazi zespleen cell kwaye yongeze ngakumbi impendulo ehlekisayo yeempuku kwiiseli zegazi ezibomvu zegusha.I-decoction ye-peony emhlophe inokuchasa umphumo wokuthintela we-cyclophosphamide kwi-peripheral blood T lymphocytes kwiigundane, ibuyisele kumanqanaba aqhelekileyo, kwaye ibuyisele umsebenzi ophantsi wokuzivikela weselula kwisiqhelo.Iyonke i-glycosides ye-paeony inokukhuthaza ukwanda kwe-splenic lymphocytes kwiimpuku ezenziwa yi-concanavalin, ikhuthaze ukuveliswa kwe-α-interferon kwintambo yegazi leukocytes ebangelwa yintsholongwane yesifo senkukhu yaseNewcastle, kwaye ibe nefuthe le-bidirectional kwimveliso ye-interleukin-2 kwi-rat. i-splenocytes eyenziwa yi-concanavalin.isiphumo esilawulayo.
9. Ukomeleza: Isicatshulwa sotywala se-peony esimhlophe sinokwandisa ixesha lokuqubha leempuku kunye nexesha le-hypoxic lokusinda kweempuku, kwaye linempembelelo ethile yokomeleza.
10. Imiphumo ye-Anti-mutagenic kunye ne-anti-tumor Isicatshulwa se-peony esimhlophe sinokuphazamisa umsebenzi we-enzyme yomxube we-S9, kwaye inokwenza i-metabolites ye-benzopyrene ingasebenzi kwaye inqanda umphumo wayo we-mutagenic.

11. Ezinye iziphumo (1) I-Antipyretic effect: I-Paeoniflorin inempembelelo ye-antipyretic kwiigundane ezinomkhuhlane wokufakelwa kwaye inokunciphisa ubushushu bomzimba obuqhelekileyo beegundane.(2) Impembelelo yokuphucula imemori: I-glycosides epheleleyo ye-paeony inokuphucula ukufunda okungahambi kakuhle kunye nokufumana imemori kwiigundane ezibangelwa yi-scopolamine.(3) Impembelelo ye-Anti-hypoxic: I-glycosides epheleleyo ye-paeony emhlophe inokwandisa ixesha lokusinda kweegundane phantsi koxinzelelo oluqhelekileyo kunye ne-hypoxia, ukunciphisa ukusetyenziswa kwe-oksijini yonke yeempuku, kunye nokunciphisa ukufa kweegundane ngenxa yetyhefu ye-potassium cyanide kunye ne-hypoxia.