Igama Lomkhiqizo:I-Galantamine Hydrobromide
Elinye Igama:I-Galanthamine hydrobromide;Galantamine HBr; I-Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,IHydrobromide
I-CAS NO:1953-04-4
Imininingwane:98.0%
Umbala:Emhlopheimpushana enephunga sici nokunambitha
Isimo se-GMO:GMO Mahhala
Ukupakisha: ku-25kgs fiber drums
Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile
Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza
I-Galantamine isetshenziselwa ukwelapha isifo i-Alzheimer's emaphakathi kuya komaphakathi kanye nokunye ukukhubazeka kwenkumbulo, ikakhulukazi lokho okusuka emithanjeni yegazi. I-alkaloid etholakala ngokwenziwa noma kuma-bulb nezimbali ze-Galanthus Caucasicus (i-Caucasian snowdrop, i-Voronov's snowdrop), i-Galanthus woronowii (Amaryllidaceae) kanye nohlobo oluhlobene olufana ne-Narcissus (daffodil)), i-Leucojum(iqhwa leqhwa elihlanganisa i-Lycoris) I-Red Spider Lily).
I-Galanthamine ingokwemvelo ekhishwe ku-lycoris radiate, iyi-alkaloid ephakeme etholakala ekuweni kweqhwa kanye nezinhlobo ezihlobene eduze. Isebenza njenge-reversible competitive acetylcholinesterase inhibitor (ACHE) inhibitor, kuyilapho isebenza buthakathaka ku-butyrylcholinesterse(BuChE).isetshenziselwa ukwelapha ukuphazamiseka kwesistimu yemizwa emaphakathi futhi ingasetshenziswa njengekhambi lokuphumuza imisipha okungapholi.I-Galanthamine hydrobromide iyi-a. impushana emhlophe cishe emhlophe; encibilika kancane emanzini; i-chloroform engancibiliki, i-ether notshwala .
I-Galantamine hydrobromide iyi-benzazepine etholakala kuma-bulb nezimbali ze-narcissus, i-osmanthus, noma i-canna. Futhi iyi-oral cholinesterase inhibitor. Njenge-ligand ye-nicotinic acetylcholine receptors, iye yasetshenziswa kabanzi ukuthuthukisa umsebenzi we-neurocognitive. Umsebenzi wayo ukuvimbela ngokuncintisana nangokuhlehla i-acetylcholinesterase, ngaleyo ndlela kwandise ukugcwala kwe-acetylcholine. Lapho ingena egazini, i-galantamine hydrobromide ingena kalula ezingxenyeni ezihlukahlukene zomzimba, kuhlanganise nobuchopho. Ibophezela kuma-nicotinic acetylcholine receptors, okubangela izinguquko ezihambisanayo nokwandisa ukukhululwa kwe-acetylcholine. Isebenza futhi ngokuncintisana kanye nokubuyisela emuva imiphumela ye-cholinesterase inhibitors. Ngokuvimbela i-cholinesterase, ivimbela ukuwohloka kwe-acetylcholine, ngaleyo ndlela ikhulise amazinga kanye nobude be-neurotransmitter enamandla. I-Galantamine ingase futhi ithuthukise ukufunda nenkumbulo, ivimbele ukuvuvukala kobuchopho, futhi igcine amazinga aphezulu ama-neurotransmitters ngokugcina ubuqotho bama-neurons nama-synapses.
Umsebenzi:
(1) I-Anti-cholinesterase .
(2) Khuthaza futhi uvimbele i-acetylcholinesterase, lawula isikhundla se-intracephalic nicotine receptor.
(3) Yelapha i-sequelae yokukhubazeka kwengane, i-sweeny ne-myasthenia gravis pseudoparalytica, njll.
(4) Thuthukisa umsebenzi wokuqashelwa kokukhanya, iziguli ze-Alzheimer ezincane kakhulu, futhi ulibazise inqubo yokuncipha kokusebenza kwamangqamuzana obuchopho.
(5) Thuthukisa ukuqhutshwa phakathi kwemizwa nemisipha.
Isicelo
1. I-galanthamineIHydrobromideisetshenziswa kakhulu ku-myasthenia gravis, i-poliovirus quiescent stage kanye ne-sequela, futhi ku-polyneuritis, i-funiculitis kanye ne-sensorimotor barrier ebangelwa isifo sezinzwa noma i-traumatism;
2. I-Galanthamine Hydrobromide nayo isetshenziswa esifweni se-Alzheimer's, inomsebenzi oyinhloko wokuwohloka komqondo kanye ne-dysmnesia ebangelwa ukulimala kobuchopho bezinto eziphilayo.
