Dzina lazogulitsa: 4-Butylresorcinol ufa
Kufotokozera: 98% min
Nambala ya CAS: 18979-61-8
Mawu ofanana achingerezi: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,4-DIHYDROXY-N-BUTYLBENZEN
Molecular formula: C10H14O2
Kulemera kwa molekyulu: 166.22
Malo osungunuka: 50 ~ 55 ℃
Malo otentha: 166 ℃/7mmHg(lit.)
Mlingo: 0.1-5%
Phukusi: 1kg, 25kg
Kodi 4-Butylresorcinol ndi chiyani
Dzina lovomerezeka la mankhwala ndi 4-n-butyl resorcinol, koma kawirikawiri, aliyense amakonda kuphweka kulemba butyl resorcinol.Yoyamba kuiwonjezera kuzinthu zoyera ndi POLA yaku Japan, um~ yomwe imadalira piritsi loyera pamoto wapakhomo.
Amadziwika ndi kusasungunuka bwino m'madzi komanso kusungunuka mu Mowa.
Mechanism zochita za 4-Butylresorcinol
- Tyrosinase imagwira ntchito yofunika kwambiri pakupanga melanin chifukwa imayang'anira kuchuluka kwa melanin.
- 4-n-butylresorcinol imalepheretsa kupanga melanin mwa kuletsa mwachindunji ntchito ya tyrosinase ndi B16 maselo otupa akuda omwe amalepheretsa kaphatikizidwe ka tyrosinase popanda kuyambitsa cytotoxicity.
- M'maphunziro ena a in vitro, 4-n-butylresorcinol idawonetsedwa kuti imaletsa kupanga melanin, komanso ntchito ya tyrosinase ndi TRP-1.
- Mphamvu yoletsa ya tyrosinase ndi peroxidase
- Ogwira khungu whitening wothandizira ndi yachibadwa khungu tona
- The ogwira whitening wothandizira kwa pigmentation khungu
- Zothandiza polimbana ndi chloasma (khungu lowoneka bwino padzuwa)
- Ili ndi mphamvu yoteteza kwambiri kuwonongeka kwa DNA komwe kumabwera chifukwa cha H2O2.
- Zatsimikiziridwa kuti ali ndi anti-glycation effect
Ubwino wa 4-Butylresorcinol
Chifukwa chiyani muyenera kusankha 4-Butylresorcinol
Choyamba, tiyenera kudziwa chifukwa chake pali resorcinol.
Lipofuscin ndi imodzi mwazovuta kwambiri kuthana nazo mu melanin.Nthawi zambiri, hydroquinone imagwiritsidwa ntchito kukongola kwachipatala.
Hydroquinone ndiwothandiza kwambiri poyera.Njira yoyera imalepheretsa ntchito ya tyrosinase ndikuletsa mapangidwe a melanin, ndipo zotsatira zake ndizodabwitsa kwambiri.
Komabe, zotsatira zake zimakhala zoonekeratu, ndipo ubwino wake ndi wovulaza kwambiri kuposa ubwino wa whitening.
- Ndi oxidizable kwambiri mumlengalenga, ndipo iyenera kugwiritsidwa ntchito powonjezera zodzoladzola.
- kungayambitse kufiira kwa khungu;
- Ngati ndende kuposa 5%, izo kuyambitsa tcheru, ndipo pali matenda zitsanzo leukoplakia.Pakadali pano, US Food and Drug Administration ikunena kuti mankhwala a hydroquinone okhala ndi ndende yopitilira 4% ndi kalasi yachipatala ndipo saloledwa kugulitsidwa.
Akatswiri a zamankhwala ndi azamankhwala asintha mankhwala amphamvu a hydroquinone kuti apeze 4-hydroxyphenyl-beta-D-glucopyranoside, zomwe nthawi zambiri timamva za "arbutin".Kusiyana kwa hydroquinone ndikuti arbutin ali ndi mchira wawung'ono - glycoside kuposa hydroquinone.Ndizomvetsa chisoni kuti zotsatira zoyera zimachepetsedwa kwambiri.
Zaka zaposachedwa, zosakaniza zodziwika bwino zamitundu yayikulu ndizochokera ku benzenediol.
Koma kukhazikika kopepuka kwa arbutin ndikotsika kwambiri ndipo kumangogwira ntchito usiku.
Chitetezo cha 4-n-butyl resorcinol chakhala chofunikira kwambiri.Popanda zotsatira zoyipa za hydroquinone, imakhala ndi machiritso abwinoko kuposa zotumphukira zina za resorcinol.
Mu kuyesa koletsa ntchito ya tyrosinase, deta yake ndiyabwino kuposa phenethyl resorcinol, yomwe ndi nthawi 100 ~ 6000 yazinthu zoyera zoyera monga kojic acid arbutin!
Kenako mu zoyeserera zapamwamba zoyeserera za melanin B16V, zidawonetsanso mwayi wamba wa zotumphukira za resorcinol - kuletsa kupanga melanin pazambiri zomwe sizinapangitse cytotoxicity.
Kuphatikiza apo, pali zoyeserera zambiri za anthu pa 4-n-butyl resorcinol.Odwala ena 32 omwe ali ndi chloasma, 0.3% 4-n-butylresorcinol ndi placebo adagwiritsidwa ntchito pamasaya onse awiri.Kawiri pa tsiku kwa miyezi ya 3, zotsatira zake zinali zotsika kwambiri za pigment mu gulu la 4-n-butylresorcinol kusiyana ndi gulu la placebo.Pali anthu omwe amayesa kuyesa kuletsa mtundu wa pigmentation atawotchedwa ndi dzuwa, hmm~ zotsatira zake ndizabwino ndithu ~
Kuletsa kwa tyrosinase yaumunthu ndi 4-butylresorcinol
4-butylresorcinol, kojic acid, arbutin ndi hydroquinone amasonyeza pa L-DOPA oxidase ntchito ya tyrosinase.Zimatsimikiziridwa ndi magawo osiyanasiyana a zoletsa kulola kuwerengera kwa IC50.Deta iyi ndi avareji ya zoyesera zitatu zodziyimira pawokha.
Kuletsa kupanga melanin mumitundu yakhungu ya MelanoDerm ndi 4-butylresorcinol
Fananizani ndi 4-butylresorcinol, kojic acid, arbutin ndi hydroquinone pakupanga melanin.Kutsimikiza kwa melanin pamitundu yapakhungu kunawonetsedwa patatha masiku 13 akulimidwa pamaso pa mitundu yosiyanasiyana ya inhibitor.Deta iyi ndi avareji ya zoyeserera zisanu zodziyimira pawokha.
Age spot lightning ndi 4-butylresorcinol
Yerekezerani ndi 4-butylresorcinol, kojic acid, arbutin ndi hydroquinone.Chitani mawangawo kawiri pa tsiku kwa milungu 12 ndi choletsa.Unikani mphamvu pambuyo pa masabata 4, 8 ndi 12.Deta imayimira tanthauzo la maphunziro 14.*P <0.05: Zowerengera zowerengera motsutsana ndi mawanga osasinthika azaka.
Mlingo ndi kugwiritsa ntchito 4-Butylresorcinol
Mlingo wovomerezeka ndi 0.5% -5%.Ngakhale pali maphunziro ku Korea kuti ndi zotsatira zina pa 0.1% zonona, ndi India ali kafukufuku 0,3% kirimu koma msika makamaka 0.5% -5%.Ndizofala kwambiri, ndipo njira ya ku Japan sinadziwikebe, koma POLA yakhala ikugwiritsidwa ntchito.Ndipo zotsatira zake ndi malonda ndi ochititsa chidwi.
Monga tafotokozera pamwambapa, 4-Butylresorcinol imatha kugwiritsidwa ntchito muzopaka, koma imasungunuka m'madzi.Zina monga mafuta odzola, mafuta odzola, ndi ma gelisi ziliponso.Onse POLA ndi Eucerin ali ndi 4-Butylresorcinol mankhwala.
