Igama Lomkhiqizo:I-Agomelatine

Elinye Igama:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide

Inombolo ye-CAS:138112-76-2

Imininingwane: 99.0%

Umbala: Impushana emhlophe emhlophe enephunga elibonakalayo kanye nokunambitha

Isimo se-GMO:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-Agomelatinewuhlobo olusha lwe-antidepressant. Indlela yayo yokusebenza inqamula ohlelweni lwendabuko lwe-monoamine transmitter.I-Agomelatine i-agonist ye-melatoninergic kanye nomphikisi okhethiwe wama-receptors we-5-HT2C, futhi iboniswe ukuthi iyasebenza ezilwaneni eziningana zokucindezeleka. I-Agomelatine (S20098) ibonise amanani e-pKi angu-6.4 no-6.2 komdabu (ingulube) kanye nama-receptors ahlanganisiwe, omuntu (h)5-hydroxytryptamine (5-HT)2C, ngokulandelanayo.

I-Agomelatine uhlobo olulodwa lwempushana emhlophe emhlophe noma emhlophe noma okuqinile okumhlophe. Igama le-IUPAC laleli khemikhali yi-N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. Le khemikhali ingeye-Aromatics Compounds;Aromatics;Neurochemicals;APIS. Kufanele igcinwe ku -20°C Isiqandisi.

 
Njenge-Pharmaceutical Intermediates, i-Agomelatine isetshenziswa ekwelapheni ukuphazamiseka okukhulu kokucindezeleka, ukuphazamiseka kwemizwelo. I-Agomelatine isetshenziswa ekwelapheni ukuphazamiseka okukhulu kokucindezeleka, ukuphazamiseka kwemizwelo. Isidakamizwa se-Nervous System. I-antidepressant, i-anxiolytic, ilungisa isigqi sokulala kanye nokulawula iwashi lebhayoloji. I-Agomelatine iyi-agonist ye-melatoninergic kanye nomphikisi okhethiwe wama-5-ht2c receptors. I-Agomelatine iyisidakamizwa esidambisa ukucindezeleka. Ihlukaniswa njenge-norepinephrine-dopamine disinhibitor (NDDI) ngenxa yokuphikiswa kwayo kwesamukeli se-5-HT2C. I-Agomelatine iphinde ibe i-agonist enamandla kuma-melatonin receptors okwenza kube yi-melatonergic antidepressant yokuqala.

.I-Agomelatine ngokwesakhiwo ihlobene eduze ne-melatonin. I-Agomelatine iyi-agonist enamandla kuma-melatonin receptors kanye nomphikisi kuma-serotonin-2C (5-HT2C) receptors, ahlolwe kumodeli yezilwane yokudangala.

I-Agomelatine iyi-antidepressant esetshenziselwa ukwelapha ukudangala.

Ubuchopho buvame ukwenza isiqiniseko sokuthi sinamakhemikhali anele esiwadingayo ukuze sisebenze kahle. Kodwa ukucindezeleka kungathinta inqwaba yamakhemikhali obuchopho.

Lawa makhemikhali ahlanganisa i-noradrenaline, i-dopamine ne-serotonin; ukucindezeleka kunciphisa amazinga alaba bathumeli bobuchopho. Ukucindezeleka kuphinde kuthinte ikhemikhali ebizwa ngokuthi i-melatonin. I-melatonin encishisiwe ihlotshaniswa nokuphazamiseka kwendlela yethu yokulala.

I-Agomelatine iyi-antidepressant yokuqala yokwandisa umsebenzi we-melatonin ngokuqondile. Lokhu ikwenza ngokwenza njenge-melatonin ezindaweni eziqondiwe lapho i-melatonin isebenza khona. (Lezi zaziwa ngokuthi ama-melatonin receptors). Ngokwandisa umsebenzi we-melatonin, i-agomelatine iphinde ikhulise ngokuqondile umsebenzi we-noradrenaline ne-dopamine.

I-Agomelatine yethulwa okokuqala e-Europe ngo-2009 futhi manje isigunyazwe ukusetshenziswa emazweni angaphezu kuka-70. Ngokungafani nama-antidepressants endabuko, i-agomelatine isebenza ngokukhomba i-melatonin nama-serotonin receptors ebuchosheni. Ngokusebenza njenge-agonist kuma-melatonin receptors, i-agomelatine isiza ukwenza kube ngokwejwayelekile amaphethini okulala aphazamisekile avame ukuhlotshaniswa nokudangala. Lo mshini awusizi nje kuphela ukuthuthukisa ikhwalithi yokulala kodwa futhi usiza ukubuyisela isigqi semvelo se-circadian. Ngaphezu kwalokho, i-agomelatine yenza njengomphikisi kuma-serotonin receptors athile (ama-5-HT2C receptors). Lesi senzo esikabili esiyingqayizivele sithuthukisa ngokungaqondile ukutholakala kwe-serotonin ebuchosheni, i-neurotransmitter enesibopho sokulawula isimo sengqondo. Ngokulawula amazinga e-serotonin, i-agomelatine ingasebenza njenge-antidepressant ephumelelayo, ekhulula izimpawu ezifana nokudabuka, ukulahlekelwa isithakazelo, imizwa yecala noma yokungabi nto yalutho. Ukwengeza, i-agomelatine ingase inikeze ezinye izinzuzo. Ucwaningo luphakamisa ukuthi lungasiza ukuthuthukisa ukusebenza kwengqondo Ucwaningo lubonisa amandla alo okuthuthukisa inkumbulo, ukunaka, kanye nomsebenzi wokuphatha, okwenza kube indawo ethokozisayo yocwaningo lwangomuso.

Umsebenzi:

I-Agomelatine ingasiza ekulawuleni 'iwashi lakho lomzimba' (isigqi se-circadian) ngezinzuzo ezinhle ekucindezelekeni kwemizwa kanye ne-sleein I-Agomelatine isetshenziswa ekwelapheni ukudangala noma ukusiza ukuvimbela ukubuya kokucindezeleka, futhi itholakala yodwa kanye nencwadi kadokotela. Izimpawu zokucindezeleka ziyehluka kumuntu oyedwa, kodwa ngokuvamile zihlanganisa ukudabuka okuqhubekayo, ukuphelelwa isithakazelo ezintweni ozithandayo, imizwa yokuzizwa ungento yalutho, izinkinga zokulala, umuzwa wokuncipha, imizwa yokukhathazeka noma ukushintsha kwesifiso sokudla nesisindo. Izinguquko ekulaleni kwakho kwansuku zonke kanye nezindlela zakho zokudla ziyizibonelo zokuphazamiseka kwewashi lomzimba wakho okwenzeka ngokuvamile ukucindezeleka.