ukukhishwa kwe-peony emhlophe

Igama Lomkhiqizo:I-White Peony Extractimpushana

Elinye Igama:I-Chinese White Blossom Extract Powder

Umthombo Wezitshalo:I-Radix Paeoniae Alba

Izithako:Isamba se-glucosides ye-Paeonia (TGP):I-Paeoniflorin, Oxypaeoniflorin, Albiflorin, Benzoylpaeoniflorin

Imininingwane:I-Paeoniflorin10%~40% (HPLC), 1.5%I-Albasides, 80%Ama-glycosides

Inombolo ye-CAS:23180-57-6

Umbala: Ophuzi-nsunduimpushananephunga sici kanye ukunambitheka

I-GMOIsimo:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-White Peony Extractibhekisela ekukhishweni kwezithako ezisebenzayo ku-peony emhlophe ngezindlela zesayensi ngokusho kobuchwepheshe obuyingqayizivele.Ngokusho kokuhlaziywa kwezazi, izithako ezisebenzayo ze-peony emhlophe ekhishwe emzimbeni womuntu zimi kanje Ishadi.Ezine kwezibaluleke kakhulu yiPaeoniflorin, Oxypaeoniflorin, Albiflorin, neBenzoylpaeoniflorin.

Ukukhishwa kwe-peony emhlophe kukhishwa empandeni eyomile ye-Paeonia lactiflora Pall., isitshalo somndeni we-Ranunculaceae.Ingxenye yayo eyinhloko yi-paeoniflorin, engasetshenziswa kabanzi hhayi emkhakheni wezokwelapha kuphela kodwa nasembonini yezimonyo.Ukukhishwa kwe-peony emhlophe kuyisivimbeli somsebenzi esisebenza kahle kakhulu se-PDE4.Ngokuvimbela umsebenzi we-PDE4, ingenza i-cAMP yamaseli ahlukahlukene okuvuvukala namasosha omzimba (njengama-neutrophils, macrophages, T lymphocytes nama-eosinophils, njll.) afinyelele ekugxilweni okwanele ukuvimbela ukusebenza kwamangqamuzana okuvuvukala futhi enze umphumela wokulwa nokuvuvukala.Iphinde ibe ne-analgesic, i-antispasmodic, i-anti-ulcer, i-vasodilator, ukwanda kwegazi lesitho, i-antibacterial, ivikela isibindi, i-detoxifying, i-anti-mutagenic, ne-anti-tumor effects.

I-glucose engu-1,2,3,6-tetragalloyl, i-1,2,3,4,6-pentagalloyl glucose kanye ne-hexagalloyl glucose ehambisanayo ne-heptagalloyl glucose ziye zahlukaniswa ku-tannin yempande emhlophe ye-peony.Futhi iqukethe i-dextrorotatory catechin namafutha aguquguqukayo.Amafutha aguquguqukayo ikakhulukazi aqukethe i-benzoic acid, i-peony phenol nezinye i-alcohols nama-phenols.1. I-Paeoniflorin: ifomula yamangqamuzana C23H28O11, isisindo samangqamuzana 480.45.I-Hygroscopic amorphous powder, [α]D16-12.8° (C=4.6, i-methanol), i-tetraacetate iyikristalu yenaliti engenambala, mp.196℃.2. I-Paeonol: Omqondofana yi-paeonol, i-peony alcohol, i-paeonal, ne-peonol.Ifomula ye-molecular C9H10O3, isisindo samangqamuzana 166.7.Amakristalu amise njengenaliti angenambala (ethanol), mp.50℃, ancibilika kancane emanzini, angashintshashintsha ngomhwamuko wamanzi, ancibilike ku-ethanol, ether, acetone, chloroform, benzene ne-carbon disulfide.3. Okunye: Iqukethe inani elincane le-oxypaeoniflorin, i-albiforin, i-benzoylpaeoniflorin, i-lactiflorin, i-monoterpene paeoniflorigenone entsha enomphumela wokuvimba kwe-neuromuscular kumagundane, i-1,2,3,4,6-Pentagalloylglucose enomphumela wokulwa namagciwane, i-gallotannin, i-d-gallic i-asidi, i-ethyl gallate, i-tannin, i-β-sitosterol, ushukela, isitashi, amafinyila, njll.

Imisebenzi:

1. I-anti-inflammatory, antibacterial kanye ne-antiviral effect.Ukukhishwa kwe-peony emhlophe kunomphumela obalulekile wokuvimbela iqanda elimhlophe i-edema evuthayo evuthayo kumagundane futhi kuvimbela ukwanda kwe-granuloma yebhola likakotini.Ingqikithi ye-glycosides ye-paeony inemiphumela elwa nokuvuvukala futhi encike emzimbeni kumagundane ane-adjuvant arthritis.Amalungiselelo e-peony amhlophe anemiphumela ethile yokuvimbela i-Staphylococcus aureus, i-hemolytic Streptococcus, i-pneumococcus, i-Shigella dysenteriae, i-typhoid bacillus, i-Vibrio cholerae, i-Escherichia coli ne-Pseudomonas aeruginosa.Ngaphezu kwalokho, i-peony decoction engu-1:40 ingavimbela igciwane le-Jingke 68-1 kanye ne-herpes virus.
2. Umphumela we-Hepatoprotective.Ukukhishwa kwe-peony emhlophe kunomthelela omkhulu ophikisayo ekulimaleni kwesibindi kanye nokwanda kwe-SGPT okubangelwa i-D-galactosamine.Inganciphisa i-SGPT futhi ibuyisele izilonda zamaseli esibindi kanye ne-necrosis evamile.Ukukhishwa kwe-ethanol yempande ye-peony emhlophe kunganciphisa ukwanda komsebenzi ophelele we-lactate dehydrogenase kanye ne-isoenzymes kumagundane anokulimala okukhulu kwesibindi okubangelwa i-aflatoxin.Ingqikithi ye-glycosides ye-paeony ingavimbela ukwanda kwe-SGPT kanye ne-lactate dehydrogenase kumagundane abangelwa i-carbon tetrachloride, futhi ibe nomthelela ophikisayo ekuwohlokeni kwe-eosinophilic kanye ne-necrosis yezicubu zesibindi.
3. Umphumela we-Antioxidant: I-TGP yempande ye-peony emhlophe ine-antioxidant ne-membrane yeseli imithelela yokusimamisa, futhi ingase ibe nomthelela wokukhipha ama-radicals mahhala.
4. Imiphumela yesistimu yenhliziyo nemithambo yegazi Ukukhishwa kwe-peony emhlophe kunganweba imithambo yegazi yenhliziyo ehlukanisiwe, imelane ne-acute myocardial ischemia kumagundane abangelwa i-pituitaryin, futhi kunciphise ukungezwani kwemithambo ye-peripheral futhi kwandise ukugeleza kwegazi lapho ejova emithanjeni.I-Paeoniflorin nayo inomphumela wokunwebeka emithanjeni yegazi ye-coronary kanye ne-peripheral blood, futhi ibangele ukwehla komfutho wegazi.Ucwaningo luye lwabonisa ukuthi i-paeoniflorin, isiqephu sempande ye-peony emhlophe, inomphumela ovimbelayo ekuhlanganisweni kweplatelet eyenziwe nge-ADP kumagundane e-vitro.
5. Imiphumela yamathumbu Ukukhishwa kwe-peony emhlophe kunomphumela ovimbelayo ekufinyezeni okuzenzakalelayo kwe-hyperexcitability yamathumbu kanye nokufinyela okubangelwa i-barium chloride, kodwa akunawo umthelela ekufinyezweni okubangelwa i-acetylcholine.Ingxube ekhishwe ngamanzi ye-licorice kanye nempande ye-peony emhlophe (0.21g) inomphumela obalulekile wokuvimbela ukunyakaza kwemisipha ebushelelezi yamathumbu konogwaja ku-vivo.Umthelela ohlangene walokhu okubili ungcono kunowodwa, futhi umphumela wokunciphisa imvamisa unamandla kunomphumela wokunciphisa i-amplitude.Ukunciphisa imvamisa yokufinyela kwamathumbu onogwaja emaminithini angu-20 kuya kwangu-25 ngemva kokuphathwa kwaba ngu-64.71% no-70.59% walokho eqenjini elivamile lokulawula, ngokulandelana, futhi lalinamandla kune-atropine (0.25 mg) eqenjini lokulawula elihle.I-Paeoniflorin inemiphumela evimbelayo kumashubhu amathumbu angawodwa kanye ne-vivo gastric motility ezingulubeni namagundane, kanye nemisipha eshelelayo yesibeletho samagundane, futhi ingamelana nokufinyela okubangelwa i-oxytocin.Inomphumela we-synergistic ne-Chemicalbook alcohol extract FM100 ye-licorice.I-Paeoniflorin inomphumela obalulekile wokuvimbela izilonda zamathumbu emagundwaneni abangelwa ukucindezeleka okucindezelayo.
6. I-sedative, i-analgesic, ne-anticonvulsant imiphumela.Umjovo we-peony omhlophe kanye ne-paeoniflorin zombili zinemiphumela yokudambisa kanye ne-analgesic.Ukujova inani elincane le-paeoniflorin kuma-ventricles obuchopho ezilwane kungabangela isimo sokulala esisobala.Umjovo we-intraperitoneal ka-1g/kg we-paeoniflorin ophuma esikhishwe yimpande ye-peony emhlophe kumagundane unganciphisa imisebenzi ezenzakalelayo yezilwane, unwebe isikhathi sokulala se-pentobarbital, uvimbele ukushwibeka kwamagundane okubangelwa umjovo we-acetic we-intraperitoneal, futhi umelane ne-pentylenetetrazole.Ukudlikizela okubangelwa.Ingqikithi ye-glycosides ye-paeony inemiphumela ebalulekile yokudambisa ubuhlungu futhi ingathuthukisa imiphumela ye-analgesic ye-morphine ne-clonidine.I-Naloxone ayithinti umphumela we-analgesic wengqikithi ye-glycosides ye-paeony, ephakamisa ukuthi isimiso sayo se-analgesic akukona ukuvuselela ama-opioid receptors.Ukukhishwa kwe-peony kungavimbela ukudlikizeka okubangelwa i-strychnine.I-Paeoniflorin ayinawo umthelela kumisipha yamathambo ehlukene, ngakho-ke kucatshangwa ukuthi umphumela wayo we-anticonvulsant umaphakathi.
7. Umthelela ohlelweni lwegazi: I-Paeony alcohol ekhishwe ingavimbela ukuhlangana kweplatelet konogwaja okubangelwa i-ADP, i-collagen, ne-arachidonic acid in vitro.
8. Umphumela kumasosha omzimba.Impande ye-peony emhlophe ingakhuthaza ukukhiqizwa kwamasosha omzimba we-spleen cell futhi ithuthukise ngokukhethekile ukusabela okuhlekisayo kwamagundane kumangqamuzana egazi abomvu ezimvu.I-peony decoction emhlophe ingaphikisana nomphumela ovimbelayo we-cyclophosphamide kuma-lymphocyte egazi e-peripheral T kumagundane, iwabuyisele emazingeni ajwayelekile, futhi ibuyisele ukusebenza kokuzivikela kweselula kokujwayelekile.Ingqikithi ye-glycosides ye-paeony ingakhuthaza ukwanda kwama-splenic lymphocytes kumagundane abangelwa i-concanavalin, ikhuthaze ukukhiqizwa kwe-α-interferon emithanjeni yegazi yomuntu i-leukocyte ebangelwa igciwane lesifo sezinkukhu saseNewcastle, futhi ibe nomthelela ohlangene ekukhiqizeni i-interleukin-2 kugundane. ama-splenocyte akhiqizwa yi-concanavalin.umphumela wokulawula.
9. Ukuqinisa umphumela: I-peony emhlophe ekhishwe utshwala ingandisa isikhathi sokubhukuda samagundane kanye nesikhathi sokusinda se-hypoxic samagundane, futhi inomphumela othile wokuqinisa.
10. Imiphumela ye-Anti-mutagenic kanye ne-anti-tumor Ukukhishwa kwe-peony emhlophe kungaphazamisa umsebenzi we-enzyme wengxube ye-S9, futhi kungenza kusebenze ama-metabolites e-benzopyrene futhi kuvimbele umphumela wayo we-mutagenic.

11. Eminye imiphumela (1) Umphumela we-Antipyretic: I-Paeoniflorin inomphumela we-antipyretic kumagundane anemfiva yokwenziwa futhi inganciphisa izinga lokushisa lomzimba elivamile lamagundane.(2) Umphumela wokuthuthukisa inkumbulo: Ingqikithi ye-glycosides ye-paeony ingathuthukisa ukufunda okumpofu nokutholakala kwenkumbulo kumagundane abangelwa i-scopolamine.(3) Umthelela we-Anti-hypoxic: Ingqikithi ye-glycosides ye-paeony emhlophe ingandisa isikhathi sokuphila samagundane ngaphansi kwengcindezi evamile ne-hypoxia, inciphise ukusetshenziswa komoya-mpilo kukonke kwamagundane, futhi yehlise ukufa kwamagundane ngenxa yobuthi be-potassium cyanide kanye ne-hypoxia.