Igama Lomkhiqizo:I-PRL-8-53
OIgama layo: Methyl 3-(2-(benzylmethylamino)ethyl)benzoate hydrochloride
3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride
3-(2-(Methyl(phenylmethyl)amino)ethyl)benzoic acid methyl ester hydrochloride
Inombolo ye-CAS :51352-87-5
Isilinganiso: 98%
Ukubukeka: Impushana emhlophe
Isebenza kanjani i-PRL-8-53?
I-PRL-8-53 isuselwa ekuhlanganiseni kwe-benzoic acid ne-phenylmethylamine.Isakhiwo samakhemikhali esakhiwe kusukela ekuhlanganisweni kwalezi zinhlanganisela ezimbili kubangela inhlanganisela engasebenzisana nama-cholinergic receptors, abambe iqhaza ekulungiseni inkumbulo kanye nezinqubo zokufunda ngaphakathi kobuchopho.I-PRL-8-53 yaziwa nangokuthi yenza (ukwandisa umphumela) we-dopamine futhi ivimbele ingxenye yama-serotonin receptors.UDkt. Nikolaus Hansl wayekholelwa ukuthi le phrofayili yomphumela ingase iholele ekushintsheni kwebhalansi kumasistimu e-CNS neurotransmitter futhi iholele ekusebenzeni okuthuthukisiwe kobuhlakani.
Kube nocwaningo olulodwa lomtholampilo lwabantu olwakhelwe kusengaphambili ukuhlola imiphumela yomuthi futhi lwabonisa ukuthuthukiswa kwenkumbulo yomlomo, isikhathi sokusabela okubukwayo nokulawulwa kwemoto, ikakhulukazi kulabo abaneminyaka engaphezu kwengama-30. Abantu abadala bavame ukuba ngaphansi kwenkumbulo kakhulu. kanye nokuncipha kwengqondo, ngakho-ke, inkumbulo kanye nezithasiselo ezithuthukisa ingqondo zivame ukusebenza kangcono kuzo.
RPL-8-53 Imisebenzi:
Thuthukisa ubuhlakani bengqondo
Thuthukisa inkumbulo namandla okuncika
Thuthukisa amandla obuchopho ukuxazulula izinkinga futhi uwuvikele kunoma iyiphi ikhemikhali noma ukulimala ngokomzimba
Thuthukisa izinga lokugqugquzela
Thuthukisa ukulawulwa kwendlela yobuchopho ekhohlo/ngaphansi
Thuthukisa ukuqonda kwezinzwa
Umthamo kanye nemiphumela emibi
Ulwazi lwelungelo lobunikazi olutholakalayo lwe-PRL 8-53 luphakamisa ububanzi obungu-0.01-4mg/kg wesisindo somzimba.Nokho, njengoba lolo luhlu olukhulu kakhulu, uhla olufanele luyi-0.05-1.2 mg/kg.Lokhu kuhumusha ku-3.4mg-81.6mg kumuntu ongu-150 pound kanye no-4.55mg-109mg kumuntu wamaphawundi angu-200.Ovivinyweni lwabantu, akukho miphumela emibi eyabhalwa;Nokho, umsebenzi wezimoto oncishisiwe waphawulwa kumagundane namagundane lapho unikezwa amanani amakhulu we-PRL 8-53